Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus

Panaccione, Isabella; Iacovelli, Luisa; Nuzzo, Luigi di; Nardecchia, Francesca; Mauro, Gianluca; Janiri, Delfina; Blasi, Antonio De; Sani, Gabriele; Nicoletti, Ferdinando; Orlando, Rosamaria

doi:10.1016/j.phrs.2016.11.029

Cited by 8 publications

(4 citation statements)

References 79 publications

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“…In this case, patients with BD could present a specific vulnerability to depression caused by impairment of hippocampal‐specific functions. Hippocampal circuitry is not only involved in memory but also in a wide variety of other skills, including motivation, reward and response to stress . The complex of subiculum and presubiculum seems to be crucial in this regard .…”

Section: Discussionmentioning

confidence: 99%

Predominant polarity and hippocampal subfield volumes in Bipolar disorders

et al. 2019

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Objectives Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP. Methods We assessed 172 outpatients, diagnosed with BD according to DSM‐IV‐TR criteria, and 150 healthy control (HC) participants. High‐resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer. Results Patients with depressive PP (BD‐DP) and with uncertain PP (BD‐UP) but not with manic/hypomanic PP (BD‐MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD‐DP presented with smaller bilateral presubiculum/subiculum volumes than BD‐MP. Conclusions Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD.

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Section: Discussionmentioning

confidence: 99%

Predominant polarity and hippocampal subfield volumes in Bipolar disorders

et al. 2019

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“…Also, a study investigated the effect of PSD and Formalin on pain and anxiety, and found that PSD increased the time spent in the open arm compared to formalin [ 52 ]. Sleep loss is commonly used to create mania and bipolar depression animal models, and it is clinically proven to exacerbate psychological symptoms in elderly patients [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Transcranial Irradiation Mitigates Paradoxical Sleep Deprivation Effect in an Age-Dependent Manner: Role of BDNF and GLP-1

Lutfy,

Essawy,

Mohammed

et al. 2023

Neurochem Res

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The growing prevalence of aged sleep-deprived nations is turning into a pandemic state. Acute sleep deprivation (SD) accompanies aging, changing the hippocampal cellular pattern, neurogenesis pathway expression, and aggravating cognitive deterioration. The present study investigated the ability of Near Infra Red (NIR) light laser to ameliorate cognitive impairment induced by SD in young and senile rats. Wistar rats ≤ 2 months (young) and ≥ 14 months (senile) were sleep-deprived for 72 h with or without transcranial administration of NIR laser of 830 nm. Our results showed that NIR photobiomodulation (PBM) attenuated cognitive deterioration made by SD in young, but not senile rats, while both sleep-deprived young and senile rats exhibited decreased anxiety (mania)-like behavior in response to PBM. NIR PBM had an inhibitory effect on AChE, enhanced the production of ACh, attenuated ROS, and regulated cell apoptosis factors such as Bax and Bcl-2. NIR increased mRNA expression of BDNF and GLP-1 in senile rats, thus facilitating neuronal survival and differentiation. The present findings also revealed that age exerts an additive factor to the cellular assaults produced by SD where hippocampal damages made in 2-month rats were less severe than those of the aged one. In conclusion, NIR PBM seems to promote cellular longevity of senile hippocampal cells by combating ROS, elevating neurotrophic factors, thus improving cognitive performance. The present findings provide NIR as a possible candidate for hippocampal neuronal insults accompanying aging and SD.

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“…21,22 SD markedly suppresses the mRNA and protein expressions of type-2 metabotropic glutamate (mGlu2) receptors in the hippocampus. 43 However, BE normalized the increased release of neurometabolites in the hippocampus, hypothalamus, and corpus striatum after SD. BE markedly down-regulated the levels of neuroinflammatory markers, such as TNF-α, CRP, IL-6 and ROS in the brain.…”

Section: Food and Function Papermentioning

confidence: 96%