Constitutive overexpressed type I interferon induced downregulation of antiviral activity in medaka fish ( Oryzias latipes )

Maekawa, Shun; Aoki, Takashi; Wang, Han Ching

doi:10.1016/j.dci.2016.11.003

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…In mammals, IFN transgenic mice are male sterility due to a continuous and excess IFN signaling, 36 , 37 , 38 although displaying a significantly enhanced viral resistance in some cases. 39 By contrast, IFN transgenic medaka ( Oryzias latipes ) exhibits an increased susceptibility to virus infection and an impaired IFN signaling likely by a prolonged exposure to IFN at high levels, 10 a desensitization effect as found in human. 40 These results indicate that, to appropriately promote host IFN response, just toward virus infection but not in normal conditions, might be essential for host survival against virus infection.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the necessity of cellular IFN response, unregulated IFN expression is pathogenic and often fatal in mammals, 6 and in fish, an IFN-transgenic medaka strain yields an increased susceptibility to viral infection. 10 However, comparison analyses of different clones of Gibel carp ( Carassius auratus gibelio ) reveal the relevance of a high virus resistance to a high IFN level, 11 , 12 , 13 indicating that appropriately promoting IFN response might be beneficial to largely improve fish resistance to viral infection, although there is a lack of useful genes for genome editing.…”

Section: Introductionmentioning

confidence: 99%

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Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity

Qu,

Gong,

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity

Qu,

Gong,

et al. 2024

iScience

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“…Mudla et al [50] demonstrated that IFN-I action is controlled by a regulatory network composed of a fast-acting positive feedback loop and a delayed negative feedback loop. Also, Maekawa et al [51] in an animal model of Medaka fish, showed that long-term and excessive IFN stimulation leads to reduced sensitivity to the IFN signal through a negative feedback loop. Some studies reported that tripartite motif protein (TRIM) 29 and 30α, ubiquitin E3 ligase, acts as a negative regulator of innate immune response in the STING-TBK1-IRF3 signaling pathway [52,53].…”

Section: Discussionmentioning

confidence: 99%

Diminution of STING Expression in the Blood of Patients with Severe or Critical COVID-19 Pneumonia

Rezaei

Marjani

Mirahmadi

et al. 2022

Int Arch Allergy Immunol

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Introduction: Cytokine storm and critical COVID-19 pneumonia are caused in at least 10% of patients by inborn errors of or auto-Abs to type I IFNs. The pathogenesis of life-threatening COVID-19 pneumonia in other patients remains unknown. Methods: This study was conducted at Masih Daneshvari Hospital, Tehran, Iran. In the period of study, 75 confirmed cases of COVID-19 with presentations ranging from mild upper respiratory tract infection to lower respiratory tract infection, including moderate, severe, and critical disease, were recruited. Expression of STING mRNA was measured in peripheral blood mononuclear cells (PBMCs) and compared between patients with different severity and outcome. Results: There was a significant negative correlation between age and STING expression level (p value = 0.010). Patients with “severe to critical” illness had a 20-fold lower STING expression level compared to the “mild to moderate” group (p value = 0.001). Also, the results showed lower expressions of STING in the patients admitted to the ICU (p value = 0.015). Patients who finally died had lower expression of STING at the time of sampling (p value = 0.041). Conclusion: STING mRNA expression in PBMCs was significantly lower in older COVID-19 cases, the patients with more severe illness, who needed intensive care, and who eventually died.

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“…Various viruses have been shown to inhibit the IFN signaling through different escape strategies to promote virus replication and release [51–54]. On the other hand, host might adopt a negative feedback mechanism to respond excessive and long-term IFN stimulation, which prevents inappropriate antiviral reactions and autoimmunity [55–57]. For example, compared to wildtype (WT), the expression levels of IFN-signal modulators ( stat1b , stat2 , mad5 , mita , irf3 , and ifr9 ), ISGs ( mx , gig1a , isg15 , and isg56 ) and ifnλ were down-regulated in IFNd-Tg fish, a transgenic medaka ( Oryzias latipes ) that constitutively overexpressed the ifnd gene [57].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, host might adopt a negative feedback mechanism to respond excessive and long-term IFN stimulation, which prevents inappropriate antiviral reactions and autoimmunity [55–57]. For example, compared to wildtype (WT), the expression levels of IFN-signal modulators ( stat1b , stat2 , mad5 , mita , irf3 , and ifr9 ), ISGs ( mx , gig1a , isg15 , and isg56 ) and ifnλ were down-regulated in IFNd-Tg fish, a transgenic medaka ( Oryzias latipes ) that constitutively overexpressed the ifnd gene [57]. Different from the immediately up-regulated expression of IFN system genes in resistant clone H at 1 dpi, most of them were up-regulated at 3–5 dpi in susceptible clone A + [40], indicating that the delay of IFN response might affect the expression of IFN system genes in the survivors of susceptible clone A + .…”

Section: Discussionmentioning

confidence: 99%

Differential expression of innate and adaptive immune genes in the survivors of three gibel carp gynogenetic clones after herpesvirus challenge

Gao

Wang

et al. 2019

BMC Genomics

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Background Accompanied with rapid growth and high density aquaculture, gibel carp has been seriously threatened by Carassius auratus herpesvirus ( Ca HV) since 2012. In previous study, distinct Ca HV resistances and immune responses were revealed in the diseased individuals of three gibel carp gynogenetic clones (A + , F and H). However, little is known about the gene expression changes in the survivors after Ca HV challenge, particularly their differences of innate and adaptive immune system between susceptible clone and resistant clone. Results We firstly confirmed the Ca HV carrier state in the survivors of three gibel carp clones after Ca HV challenge by evaluating the abundances of five Ca HV genes. The assay of viral loads indicated the resistant clone H possessed not only stronger resistance but also higher tolerance to Ca HV. Then, 2818, 4047 and 3323 differentially expressed unigenes (DEUs) were screened from the head-kidney transcriptome profiles of survivors compared with controls from clone A + , F and H. GO and KEGG analysis suggested that a persistent immune response might sustain in resistant clone H and F, while susceptible clone A + had a long-term impact on the circulatory system which was consistent with the major symptoms of bleeding caused by Ca HV. Among the top 30 enriched pathways of specifically up-regulated DEUs in respective clones, 26, 7 and 15 pathways in clone H, F and A + were associated with infections, diseases, or immune-related pathways respectively. In addition, 20 pathways in clone F belonged to “metabolism” or “biogenesis”, and 7 pathways involved in “circulatory system” were enriched in clone A + . Significantly, we revealed the differential expression changes of IFN system genes and immunoglobulin (Ig) genes among the survivors of three clones. Finally, myosins and Igs were identified as co-expression modules which were positively or negatively correlated to Ca HV viral loads respectively. Conclusions Our results revealed the common and distinct gene expression changes in immune and circulatory system in the survivors of three gibel carp gynogenetic clones with different Ca HV resistances. The current study represents a paradigm of differential innate and adaptive immune reactions in teleost, and will be beneficial to the disease-resistance breeding of gibel carp. Electronic supplementary material The online version of this article (10.1186/s12864-019-5777-z) contains supplementary material, which is available to authorized users.

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Constitutive overexpressed type I interferon induced downregulation of antiviral activity in medaka fish ( Oryzias latipes )

Cited by 7 publications

References 45 publications

Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity

Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity

Diminution of STING Expression in the Blood of Patients with Severe or Critical COVID-19 Pneumonia

Differential expression of innate and adaptive immune genes in the survivors of three gibel carp gynogenetic clones after herpesvirus challenge

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