Oxygen Uptake Recovery Kinetics after the 6-Minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease

Abstract

Background: There is a growing interest in exercise parameters capable of objectively evaluating the functional capacity of patients with chronic obstructive pulmonary disease (COPD). Objectives: The purpose of the present study was to analyze breath-by-breath cardiopulmonary and gas exchange recovery responses of patients with COPD after a 6-minute walk test (6MWT). Methods: Oxygen uptake (VO₂) kinetics of patients were obtained using mobile telemetric cardiopulmonary monitoring during and after a 6MWT. Recovery kinetics were modelled using a 4-parameter nonlinear logistic model. Multiple linear regression was performed to assess the association between the half-time of recovery of oxygen consumption (T_1/2 VO₂) and exercise capacity (6-minute walking distance, 6MWD). Results: Sixty-nine patients with COPD (28 females) with a mean age of 65 ± 10 years took part in the study. After adjustment for covariates (body mass index, forced expiratory volume in 1 s, forced vital capacity, and age), T_1/2 VO₂ was significantly associated with 6MWD (p = 0.002). Conclusions: T_1/2 VO₂ can be used to reflect exercise capacity in patients with COPD. As T_1/2 VO₂ mostly depends on the rate of increase in pulmonary blood flow, the results of the present study underline the importance of cardiocirculatory impairment for exercise intolerance in patients with COPD.

Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity

“…The correlation between the 6MWD and %DLCO has been previously reported [17]. Moreover, our results are consistent with those of a recent report showing that oxygen uptake kinetic parameters were associated with the 6MWD [18]. The functional exercise capacity of patients with COPD deteriorates in a linear fashion with disease severity assessed using GOLD staging criteria based on the %FEV1 [19].…”

Effects of high- and moderate-intensity exercise on central hemodynamic and oxygen uptake recovery kinetics in CHF-COPD overlap

“…VO 2 recovery (T 1/2 . VO 2 )) after submaximal exercise has been associated with established parameters of exercise capacity in COPD patients (13). The authors showed that the impairment of the T 1/2 VO 2 also depends on disease severity and degree of airflow limitation, suggesting that prolonged dyspnea or leg effort after exercise, commonly experienced by COPD patients, may be understood by differences in recovery ability.…”

“…In this context, previous studies have shown that . VO 2 and HR recovery kinetics are slowed in the presence of COPD (12)(13) or CHF (8-10) on isolation, as represented by t and MRT. However, to the best of our knowledge, the recovery kinetics in patients with overlapped CHF and COPD has not been thoroughly explored.…”

Effect of high flow nasal cannula on peripheral muscle oxygenation and hemodynamic during paddling exercise in patients with chronic obstructive pulmonary disease: a randomized controlled trial

“…In the first session, the CI and SV in the HFNC group were significantly higher than those of the NC group. The higher CI and SV might be indicative of a reduced cardiac burden in the first session training in the HFNC group (30). Our results revealed that only the NC group experienced a physiological benefit of supplemental oxygen in reducing SVR.…”