Chikungunya infection: A potential re-emerging global threat

Murugan, Shanmugaraj Bala; Ramalingam, Sathishkumar

doi:10.1016/j.apjtm.2016.07.020

Cited by 26 publications

(17 citation statements)

References 48 publications

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“…Suddenly viral outbreaks in India are increasing like pandemic Influenza [17], Nipah virus [18], Zika virus [19], dengue and Chikungunya virus is one of them. Chikungunya virus is a highly infectious viral disease and well notorious since its origin from Tanzania and has the potential to re-emerging the global level [20,21]. There is no vaccine and antiviral for CHIKV.…”

Section: Determination Of Antiviral Property Of Plant Extract Of Z Omentioning

confidence: 99%

Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus

et al. 2020

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Chikungunya is one of the highly infectious viral disease without vaccine and anti-viral. Aim of present study is to check the anti-chikungunya activities of Zingiber officinale (Ginger) in the animal cell culture model. The medicinal plant extract was prepared from Z. officinale rhizome. Median tissue culture infective dose (TCID 50) of Chikungunya virus (CHIKV) and Maximum non-toxic dose (MNTD) of Z. officinale extract was determined in Vero cell-line on the basis of cell viability followed by MTT assay. In vitro anti-chikungunya activity was performed in Vero cell-line with MNTD and half of MNTD of Z. officinale medicinal plant extract. The anti-viral effect of Z. officinale was studied by observing the cytopathic effects and cell viability measured by MTT assay. Maximum non-toxic dose of Z. officinale plant extract was found 62.5 μg/ml. During anti-chikungunya experimentation, cell viability increased to 51.05% and 35.10%, when Vero cells were pre-treated with MNTD and half of MNTD of Z. officinale extract respectively. Similarly, in co-treatment, when MNTD, half of MNTD of Z. officinale and Median tissue culture infective dose CHIKV were inoculated simultaneously, then the viability of Vero cell-line was increases by 52.90% and 49.02% respectively. The rhizome extracts of Z. officinale have high potential to treat CHIKV. Medicinal plants and their metabolites are most important sources of antimicrobial and can be utilized for the development of new drugs. In view of the rapid expansion of CHIKV at the global level, there is an urgent need to develop newer anti-chikungunya drugs.

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Section: Determination Of Antiviral Property Of Plant Extract Of Z Omentioning

confidence: 99%

Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus

et al. 2020

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“…1 Genetically, the CHIKV possess an enveloped structure with a single-stranded, positive RNA genome. 1 Genetically, the CHIKV possess an enveloped structure with a single-stranded, positive RNA genome.…”

Section: Virology Of Chikungunya Virusmentioning

confidence: 99%

“…1 In sequence, occurs the entry of the CHIKV virus via clathrin-dependent endocytosis and uncoating of the viral genome. Capsid protein is 261 amino acids (30 kDa) long, expressed as a part of the structural polyprotein, which has a conserved autoprotease domain at the C-terminal end that helps to release itself from the polypeptide string after synthesis of structural proteins.…”

Section: Virology Of Chikungunya Virusmentioning

confidence: 99%

The medicinal chemistry of Chikungunya virus

Silva-Júnior

Leoncini

Rodrigues

et al. 2017

Bioorganic & Medicinal Chemistry

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Arthropod-borne viruses (arboviruses) are an important threat to human and animal health globally. Among these, zoonotic diseases account for billions of cases of human illness and millions of deaths every year, representing an increasing public health problem. Chikungunya virus belongs to the genus Alphavirus of the family Togariridae, and is transmitted mainly by the bite of female mosquitoes of the Aedes aegypti and/or A. albopictus species. The focus of this review will be on the medicinal chemistry of Chikungunya virus, including synthetic and natural products, as well as rationally designed compounds.

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“…The genome size of CHIKV is 11.8 kb. The two open reading frames in CHIKV separately code for the structural and non‐structural proteins . The four non‐structural proteins (nsP1‐4) of CHIKV play an important role in the formation of replication complex, while the five structural proteins (C‐E3‐E2‐6K‐E1) encode the viral capsid and envelope protein .…”

Section: Introductionmentioning

confidence: 99%

Chikungunya virus modulates the miRNA expression patterns in human synovial fibroblasts

Agrawal

Pandey

Rastogi

et al. 2019

Journal of Medical Virology

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Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes. CHIKV infection leads to polyarthritis and polyarthralgia among patients. The synovial fibroblasts are the primary target for CHIKV. The microRNAs (miRNAs) are the small endogenous noncoding RNAs which posttranscriptionally regulate the expression of genes by binding to their target messenger RNAs (mRNAs) through their 3′‐untranslated regions. The miRNAs are the key regulators for various pathological processes including viral infection, cancer, cardiovascular disease, and neurodegeneration. This study was designed to dissect out the roles of miRNAs during CHIKV (Ross Strain E1: A226V) infection in primary human synovial fibroblasts. The miRNA microarray profiling was performed on the primary human synovial fibroblasts infected by CHIKV. The gene target prediction analysis, enrichment, and network analysis were performed by various bioinformatics analyses. The subset of 26 differentially expressed microRNAs (DEMs) were identified through microarray profiling and were further screened for gene predictions, Gene Ontology, pathway enrichment, and miRNA‐mRNA network using various bioinformatics tools. The bioinformatics analysis indicates the role of DEMs by suppressing the immune response which may contribute to CHIKV persistence in human primary synovial fibroblasts. Our study provides the plausible roles of DEMs, miRNAs, and mRNA interactions and pathways involved in the molecular pathogenesis of CHIKV.

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Chikungunya infection: A potential re-emerging global threat

Cited by 26 publications

References 48 publications

Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus

Anti-viral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus

The medicinal chemistry of Chikungunya virus

Chikungunya virus modulates the miRNA expression patterns in human synovial fibroblasts

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