Use of Tumor Necrosis Factor-Alpha Inhibitors in Children and Young Adults With Juvenile Idiopathic Arthritis or Rheumatoid Arthritis

Lee, Wan-Ju; Briars, Leslie A.; Lee, Todd A.; Calip, Gregory S.; Suda, Katie J.; Schumock, Glen T.

doi:10.1002/phar.1856

Cited by 11 publications

(5 citation statements)

References 41 publications

(105 reference statements)

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“…ere are few reports on CRA in China, and most of them are small sample studies. Lee et al [10] reported that 48 children suffered from JDM, and 3 of them died of respiratory failure due to infection. Ince-Askan et al [11] thought that children with SLE were prone to serositis, and they were often positive when they were tested for antibodies.…”

Section: Discussionmentioning

confidence: 99%

Machine Learning Based Image Feature Recognition and Clinical Nursing of Children’s Rheumatoid Arthritis-Related Lung Injury

2021

Scientific Programming

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This work was aimed at investigating image feature recognition and clinical nursing of children’s rheumatoid arthritis- (CRA-) related lung injury under maximum correlation minimum redundancy algorithm of machine learning. In this study, 18 children with CRA in the hospital were selected as the rheumatoid group to explore the nursing method, and 18 healthy children were selected as the control group. The maximum correlation minimum redundancy algorithm of machine learning was compared with the information gain algorithm and the Fisher score algorithm and applied in computed tomography (CT) images of 18 CRA children. The classification accuracy of the algorithm in this study (94.52%) was higher than that of the information gain algorithm (88.64%) and Fisher score algorithm (81.24%). CT alveolitis score (2.35 ± 0.72 points) of children from the rheumatoid group was markedly higher than that of the control group (1.21 ± 0.24 points) (t = 2.147 and P < 0.05 ). The nitric oxide level (14.00 ppb) of children from the rheumatoid group increased greatly compared with the control group (10.00 ppb) ( P < 0.05 ). CRA can cause a decline of lung function in children, while the nitric oxide level exhaled by children can assess the activity of RA. In addition, adopting active nursing methods can help children get better.

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Section: Discussionmentioning

confidence: 99%

Machine Learning Based Image Feature Recognition and Clinical Nursing of Children’s Rheumatoid Arthritis-Related Lung Injury

2021

Scientific Programming

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“…Drug persistence was defined as the time length of therapy until discontinuation, switch, or end of the study with a gap period of > 90 days, which has been used in other RA analyses. [35][36][37] We calculated total health care costs as the mean of all allowable costs for medical claims and pharmacy claims for each individual patient per 28 days. Because our drugs of interest were expected to comprise a large portion of total health care costs, we also calculated health care costs per member per month, excluding the cost for specialty RA agents, representing the total health care costs net of specialty RA agents.…”

Section: Discussionmentioning

confidence: 99%

Adherence, Persistence, and Expenditures for High-Cost Anti-Inflammatory Drugs in Rheumatoid Arthritis: An Exploratory Study

Khilfeh

Guyette

Watkins

et al. 2019

JMCP

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“…If the index TNF-α blockers were switched to other TNF-α blockers or IL-17 inhibitors, or the index TNF-α blockers were restarted >90 days (permissible gap) after the last prescription, it was considered to be non-persistent to TNF-α blockers. Literature review indicated that 90 days permissible gap has been widely used for studying the long-term adherence of TNF-α blockers for the treatment of rheumatic diseases [ 7 , 42 , 43 , 44 , 45 ]. Causes of discontinuation of anti-TNF-α agents were classified as LOE, AE, and poor health literacy based on medical chart review.…”

Section: Methodsmentioning

confidence: 99%

High Baseline Neutrophil-to-Lymphocyte Ratio Could Serve as a Biomarker for Tumor Necrosis Factor-Alpha Blockers and Their Discontinuation in Patients with Ankylosing Spondylitis

et al. 2023

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Background: This study explores the association of neutrophil-to-lymphocyte (NLR), monocyte-to-lymphocyte (MLR), and platelet-to-lymphocyte (PLR) ratios with the 3-month treatment response and persistence of tumor necrosis factor-alpha (TNF-α) blockers in patients with ankylosing spondylitis (AS). Methods: This retrospective cohort study investigated 279 AS patients who were newly initiated on TNF-α blockers between April 2004 and October 2019 and 171 sex- and age-matched healthy controls. Response to TNF-α blockers was defined as a reduction in the Bath AS Disease Activity Index of ≥50% or 20 mm, and persistence referred to the time interval from the initiation to discontinuation of TNF-α blockers. Results: Patients with AS had significantly increased NLR, MLR, and PLR ratios as compared to controls. The frequency of non-response at 3 months was 3.7%, and TNF-α blockers’ discontinuation occurred in 113 (40.5%) patients during the follow-up period. A high baseline NLR but not high baseline MLR and PLR showed an independently significant association with a higher risk of non-response at 3 months (OR = 12.3, p = 0.025) and non-persistence with TNF-α blockers (HR = 1.66, p = 0.01). Conclusions: NLR may be a potential marker for predicting the clinical response and persistence of TNF-α blockers in AS patients.

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Use of Tumor Necrosis Factor-Alpha Inhibitors in Children and Young Adults With Juvenile Idiopathic Arthritis or Rheumatoid Arthritis

Abstract: Earlier TNFI therapy was observed in 39.1% of children and young adults taking TNFIs. In addition, the time to the first TNFI prescription became shorter over the study period. Future research should evaluate the long-term effectiveness and safety of this more aggressive TNFI therapy.

Cited by 11 publications

References 41 publications

Machine Learning Based Image Feature Recognition and Clinical Nursing of Children’s Rheumatoid Arthritis-Related Lung Injury

Machine Learning Based Image Feature Recognition and Clinical Nursing of Children’s Rheumatoid Arthritis-Related Lung Injury

Adherence, Persistence, and Expenditures for High-Cost Anti-Inflammatory Drugs in Rheumatoid Arthritis: An Exploratory Study

High Baseline Neutrophil-to-Lymphocyte Ratio Could Serve as a Biomarker for Tumor Necrosis Factor-Alpha Blockers and Their Discontinuation in Patients with Ankylosing Spondylitis

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