Non-responders to cardiac resynchronization therapy: Insights from multimodality imaging and electrocardiography. A brief review

Carità, Patrizia; Corrado, Egle; Curnis, Antonio; Bontempi, Luca; Novo, Giuseppina; Guglielmo, Marco; Ciaramitaro, Gianfranco; Assennato, Pasquale; Novo, Salvatore; Coppola, Giuseppe

doi:10.1016/j.ijcard.2016.09.037

Cited by 30 publications

(20 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The non-response rate tends to be lower when using only the functional evaluation criterion (functional class). Although comparative studies do not demonstrate a direct correlation between clinical response and echocardiographic response, when a reverse remodeling criterion is associated with CRT assessment, the non-response rate was described to range from 35% to 40% [24,25]. Our results reflect this situation and the need for a more definitive classification of the problem, as when using only the FC, the response rate to CRT in the 3 groups was 82.8%, 94.9%, and 91%, respectively.…”

Section: Discussionmentioning

confidence: 53%

Clinical outcomes and mortality in old and very old patients undergoing cardiac resynchronization therapy

et al. 2019

View full text Add to dashboard Cite

AimCardiac resynchronization therapy (CRT) is a valid therapeutic option for patients with heart failure (HF). However, the elderly population was not well represented in the guidelines. The primary end point was to evaluate the impact of advanced age on clinical response and cardiovascular and total mortality of patients undergoing CRT. The secondary end point was to assess the rate of acute complications related to the procedure. Methods and resultsA total of 249 consecutive patients with HF and optimized treatment, QRS � 120 ms, ejection fraction (EF) � 35% and functional class (FC) III/ IV (NYHA) underwent CRT and divided into 3 groups: Group I-< 65 years-88/ 249 (35%); Group II-65 to 75 years (old)-72/ 249 (29%); Group III-� 75 years (very old)-89/ 249 (36%). The improvement in FC and increase in EF (>10%) and/ or decrease in the left ventricular end systolic diameter (LVESD) >15% were the criteria of responsiveness. The favorable clinical response (p = ns) and cardiovascular mortality (p = 0.737) was similar in the 3 groups. In the group of very old patients, a significant increase in total mortality was observed (p = 0.03). The rate of acute complications related to the procedure did not differ between the groups (p = ns). ConclusionThe response to CRT and cardiovascular mortality were not affected by the advanced age and should not be an exclusion factor of this therapy. The procedure has been shown to be safe in elderly patients due to low rate of acute complications.

show abstract

Section: Discussionmentioning

confidence: 53%

Clinical outcomes and mortality in old and very old patients undergoing cardiac resynchronization therapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Several authors equal to several approaches. The main thing is that interventricular delay, in general, has been proven as it has its role in left ventricular remodeling [6] or prediction of CRT clinical response many times [7,8,9]. Other studies worked with RV to LV measurements.…”

Section: Discussionmentioning

confidence: 99%

Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy

et al. 2020

View full text Add to dashboard Cite

Introduction Differences in conduction times from right ventricle to left ventricle and from left ventricle to right ventricle respectively were observed during biventricular devices implantation when changing pacing vector direction. In this article the phenomenon of interventricular conduction time differences is described and assessed in relationship to various clinical and electrophysiological parameters. Methods In 62 consecutive patients (9 females) interventricular conduction times between right and left ventricle in both directions were measured during cardiac resynchronization therapy device implantation procedure. Complex pacing protocol was performed. Results Investigated individuals was divided into 3 subgroups according to type of interventricular conduction pattern and statistically tested with various clinical data. Substantial differences in right-to-left vs left-to-right conduction times (> 5 ms, range 7-72 ms) were observed in 24 (39%) of all patients. They were more common in patients with dilated cardiomyopathy (20 of 38, 53%) compared to 4 (17%) of 24 patients with coronary artery disease (p = 0.011). The phenomenon occurred more often in hypertensive patients (p = 0.012). Other tested factors were nonsignificant. Conclusions There are almost no data on this topic. The occurrence of conduction difference phenomenon is quite common in dilated cardiomyopathy while it is rare in coronary artery disease.

show abstract

“…Noninvasive imaging-based prediction of responders vs. nonresponders to CRT would be clinically useful. There have been a number of imaging investigations in this clinical space (16). Zavadovsky and colleagues from the Russian Federation studied the role of imaging information obtained from myocardial perfusion and metabolism in their combined predictive ability in assessing CRT efficacy in 63 patients with DCM and severe NYHA class III–IV heart failure (17).…”

Section: Cardiovascularmentioning

confidence: 99%

Highlights of articles published in annals of nuclear medicine 2016

Jadvar

2017

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

This article is the first installment of highlights of selected articles published during 2016 in the Annals of Nuclear Medicine, an official peer-reviewed journal of the Japanese Society of Nuclear Medicine. A companion article highlighting selected articles published during 2016 in the European Journal of Nuclear Medicine and Molecular Imaging, which is the official peer-reviewed journal of the European Association of Nuclear Medicine, will also appear in the Annals Nuclear Medicine. This new initiative by the respective journals will continue as an annual endeavor and is anticipated to not only enhance the scientific collaboration between Europe and Japan but also facilitate global partnership in the field of nuclear medicine and molecular imaging.

show abstract

Non-responders to cardiac resynchronization therapy: Insights from multimodality imaging and electrocardiography. A brief review

Cited by 30 publications

References 62 publications

Clinical outcomes and mortality in old and very old patients undergoing cardiac resynchronization therapy

Clinical outcomes and mortality in old and very old patients undergoing cardiac resynchronization therapy

Differences in right-to-left vs left-to-right interventricular conduction times in patients indicated to cardiac resynchronization therapy

Highlights of articles published in annals of nuclear medicine 2016

Contact Info

Product

Resources

About