Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective

Brown, Alan; Drew, Philip; Knight, Brian L.; Marc, Philippe; Troth, Sean P.; Wuersch, Kuno; Zandee, Joyce

doi:10.1016/j.yrtph.2016.10.009

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…It is likely that the use of such tools will increase among pathologists as the technology and graphics continue to improve and as the visualizations are further embraced by data reviewers. The Food and Drug Administration has been actively collaborating with scientists and software developers through the Pharmaceutical Users Software Exchange (PhUSE) consortium (Brown et al 2016; Kropp et al 2013; PhUSE 2015) to evaluate the use of graphical display software for review of nonclinical data submissions. Pathologists and other scientists involved in nonclinical toxicology studies continue to play an important role in providing feedback to enable the continued development and improvement of these tools.…”

Section: Discussionmentioning

confidence: 99%

Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists

et al. 2018

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Assessment and communication of toxicology data are fundamental components of the work performed by veterinary anatomic and clinical pathologists involved in toxicology research. In recent years, there has been an evolution in the number and variety of software tools designed to facilitate the evaluation and presentation of toxicity study data. A working group of the Society of Toxicologic Pathology Scientific and Regulatory Policy Committee reviewed existing and emerging visualization technologies. This Points to Consider article reviews some of the currently available data visualization options, describes the utility of different types of graphical displays, and explores potential areas of controversy and ambiguity encountered with the use of these tools.

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Section: Discussionmentioning

confidence: 99%

Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists

et al. 2018

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“…In vertebrate species, the study of microscopic morphologic alterations (histopathology) is the basis for the diagnosis of disease or evaluation of host response to noxious stimuli. It is used extensively for diagnostics, research, and regulatory purposes (risk and safety assessment) (Bernet et al, 1999;Brown et al, 2016). However, histopathology has not been developed and utilized to the same extent in insects as it has been in vertebrate species.…”

Section: Introductionmentioning

confidence: 99%

Histomorphological description of the reproductive system in mated honey bee queens

Kozii

Wood

Koziy

et al. 2021

Journal of Apicultural Research

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The accelerating decline of pollinator populations has become increasingly concerning in the last two decades. Honey bees are economically important pollinators and a model species to evaluate pollinator health. The decline in queen quality is one of the frequently reported causes associated with honey bee losses worldwide. Histopathology is an essential tool used for diagnostics and research in mammalian species and may provide insight into the histomorphological basis of a decline in queen quality. Thus, the purpose of this study was to summarize the previously described normal morphology of the entire reproductive tract of mated honey bee queens and to illustrate it by high quality photomicrographs. Accordingly, reproductive tracts of one-year old mated honey bee queens were processed for histology, serially sectioned, stained with hematoxylin and eosin, and used for the capture of high quality histological photomicrographs of the entire reproductive tract. This study illustrates the microscopic morphology of the queen reproductive tract which may facilitate further investigations of the cause and pathogenesis of the recent decline in reproductive fitness of honey bees using histopathology.

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Software tools for toxicology and risk assessment

Mohapatra

2020

Information Resources in Toxicology

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Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective

Cited by 6 publications

References 8 publications

Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists

Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists

Histomorphological description of the reproductive system in mated honey bee queens

Software tools for toxicology and risk assessment

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