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Fang, Li; Feng, Jie; Gao, Dongmei; Wang, Jieqiong; Song, Chao; Sheng, Wei; Qiao, Mingqi

doi:10.1155/2016/7950781

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…Though our behavioral experiments revealed that fluoxetine and BXD had a similar effect on the PMDD model, some studies have shown different effects. Some studies have shown that the active compounds in BXD could ease most of symptoms of PMDD ( Lee et al, 2008 ; Nizamutdinova et al, 2008 ; Peng et al, 2010 ; Zhou et al, 2011 ; Xie et al, 2015 ), while other studies showed that fluoxetine was mainly to treat PMDD depression ( Francois et al, 2003 ; Sarkisova and Folomkina, 2010 ; Li et al, 2016 ), which is only one subtype of PMDD; these results suggest that BXD could be active on multiple targets. Through analysis of the 6 signal regulatory pathways influenced by BXD capsules, we found that BXD can alter PMDD irritability by influencing various intercellular and intracellular signal transduction pathways.…”

Section: Discussionmentioning

confidence: 99%

“…This is consistent with the chip results, demonstrating the reality and reliability of the chip results as well. Besides, another traditional Chinese medicine, Shuyu capsule, which was found to reduce 5-HT 3A R and 5-HT 3B R expression ( Li et al, 2016 ) and has some of the same herbal ingredients as BXD, was seen to effectively treat PMDD depression.…”

Section: Discussionmentioning

confidence: 99%

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Gene Expression in the Hippocampus in a Rat Model of Premenstrual Dysphoric Disorder After Treatment With Baixiangdan Capsules

et al. 2018

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Objective: To explore the targets, signal regulatory networks and mechanisms involved in Baixiangdan (BXD) capsule regulation of premenstrual dysphoric disorder (PMDD) at the gene transcription level, since the etiology and pathogenesis of PMDD are not well understood.Methods: The PMDD rat model was prepared using the resident-intruder paradigm. The rats were tested for aggressive behavior, and those with scores in the lowest 30% were used as controls, while rats with scores in the highest 30% were divided into a PMDD model group, BXD administration group and fluoxetine administration group, which were evaluated with open-field tests and aggressive behavior tests. We also analyzed gene expression profiles in the hippocampus for each group, and verified differential expression of genes by real-time PCR.Results: Before and after BXD or fluoxetine administration, scores in the open-field test exhibited no significant differences. The aggressive behavior of the PMDD model rats was improved to a degree after administration of both substances. Gene chip data indicated that 715 genes were differentially expressed in the control and BXD groups. Other group-to-group comparisons exhibited smaller numbers of differentially expressed genes. The effective targets of both drugs included the Htr2c, Cdh3, Serpinb1a, Ace, Trpv4, Cacna1a, Mapk13, Mapk8, Cyp2c13, and Htr1a genes. The results of real-time PCR tests were in accordance with the gene chip data. Based on the target genes and signaling pathway network analysis, we have elaborated the impact and likely mechanism of BXD in treating PMDD and premenstrual irritability.Conclusion: Our work contributes to the understanding of PMDD pathogenesis and the mechanisms of BXD treatment. We speculate that the differentially expressed genes could participate in neuroactive ligand-receptor interactions, mitogen-activated protein kinase, calcium, and gamma-aminobutyric acid signal transduction.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gene Expression in the Hippocampus in a Rat Model of Premenstrual Dysphoric Disorder After Treatment With Baixiangdan Capsules

et al. 2018

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“…However, exclusion of females could be a significant point against this study’s clinical relevance because depression and anxiety are more prevalent in women than in men. Actually, we noticed that some subtypes of depression or anxiety were related to fluctuating hormones [ 92 , 93 ]. Evaluating only male offspring could focus more on the “passing on” behavioural deficits caused by maternal chronic SDS.…”

Section: Discussionmentioning

confidence: 99%

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes

Sheng

Ren

et al. 2018

BMC Neurosci

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BackgroundEpidemiological surveys and studies with animal models have established a relationship between maternal stress and affective disorders in their offspring. However, whether maternal depression before pregnancy influences behaviour and related neurobiological mechanisms in the offspring has not been studied.ResultsA social defeat stress (SDS) maternal rat model was established using the resident-intruder paradigm with female specific pathogen-free Wistar rats and evaluated with behavioural tests. SDS maternal rats showed a significant reduction in sucrose preference and locomotor and exploratory activities after 4 weeks of stress. In the third week of the experiment, a reduction in body weight gain was observed in SDS animals. Sucrose preference, open field, the elevated-plus maze, light–dark box, object recognition, the Morris water maze, and forced swimming tests were performed using the 2-month-old male offspring of the female SDS rats. Offspring subjected to pre-gestational SDS displayed enhanced anxiety-like behaviours, reduced exploratory behaviours, reduced sucrose preference, and atypical despair behaviours. With regard to cognition, the offspring showed significant impairments in the retention phase of the object recognition test, but no effect was observed in the acquisition phase. These animals also showed impairments in recognition memory, as the discrimination index in the Morris water maze test in this group was significantly lower for both 1 h and 24 h memory retention compared to controls. Corticosterone, adrenocorticotropic hormone, and monoamine neurotransmitters levels were determined using enzyme immunoassays or radioimmunoassays in plasma, hypothalamus, left hippocampus, and left prefrontal cortex samples from the offspring of the SDS rats. These markers of hypothalamic–pituitary–adrenal axis responsiveness and the monoaminergic system were significantly altered in pre-gestationally stressed offspring. Brain-derived neurotrophic factor (BDNF), cyclic adenosine monophosphate response element binding protein (CREB), phosphorylated CREB (pCREB), and serotonin transporter (SERT) protein levels were evaluated using western blotting with right hippocampus and right prefrontal cortex samples. Expression levels of BDNF, pCREB, and SERT in the offspring were also altered in the hippocampus and in the prefrontal cortex; however, there was no effect on CREB.ConclusionWe conclude that SDS before pregnancy might induce depressive-like behaviours, cognitive deficits, and neurobiological alterations in the offspring.

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“…Shuyu capsule is a kind of Chinese medicine developed by our research group, mainly containing active principle from Radix Bupleuri, rhizoma cyperi, Radix Paeoniae Alba and liquorice. It has been studied in a rat model of premenstrual syndrome depression that Shuyu capsules rectified abnormal 5-HT 3 AR and 5-HT 3 BR expression and 5-HT 3 channel current changes in a rat model ( 14 ). But no pathway alterations was revealed related to depression.…”

Section: Introductionmentioning

confidence: 99%

Shuyu capsules relieve liver‑qi depression by regulating ERK‑CREB‑BDNF signal pathway in central nervous system of rat

Wang

Zhang

et al. 2017

Exp Ther Med

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The purpose of this study was to investigate the possible therapeutic mechanism of Shuyu capsules in liver-qi depression. Liver-qi depression rats were prepared based on chronic unpredictable mild stress (CUMS) and delayed constraint. Rats were gavaged with Shuyu capsule, fluoxetine, Radix Bupleuri and Radix Paeoniae Alba to constrct rat models. Body weight test, sucrose preference test and open-field test were applied to test rat models. Western blot analysis and quantitative real-time PCR was applied to determine the relative expression of extracellular signal-regulated protein kinase (ERK), cyclic AMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in hippocampus and frontal lobe tissues. ELISA was used to detect the content of BDNF in serum. Body weight, sugar intake and total distance were significantly decreased in depression group compared with control. The four drugs significantly increased levels of these factors. Compared with control group, ERK, CREB and BDNF expression were significantly decreased in depression group in both hippocampus and frontal lobe tissues at both mRNA and protein level. Shuyu capsule and fluoxetine group showed a significant increase in the expression of ERK, CREB and BDNF at mRNA, p-ERK and p-BDNF at protein level. Compared with Radix Paeoniae Alba, Radix Bupleuri were better in the rescue of ERK, CREB and BDNF expression. In conclusion, the pathogenesis of liver-qi depression associated with lower expression of ERK, CREB and BDNF in hippocampus and frontal. Shuyu capsule and main constitution alleviated the depressive-like behaviors and reversed the disruptions of the p-ERK, p-CREB and BDNF in stressed rats.

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Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing5-HT3ARand5-HT3B

Cited by 10 publications

References 41 publications

Gene Expression in the Hippocampus in a Rat Model of Premenstrual Dysphoric Disorder After Treatment With Baixiangdan Capsules

Gene Expression in the Hippocampus in a Rat Model of Premenstrual Dysphoric Disorder After Treatment With Baixiangdan Capsules

Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes

Shuyu capsules relieve liver‑qi depression by regulating ERK‑CREB‑BDNF signal pathway in central nervous system of rat

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