Green tea (Cammellia sinensis) attenuates ventricular remodeling after experimental myocardial infarction

Lustosa, Beatriz; Polegato, Bertha Furlan; Minicucci, Marcos F.; Rafacho, Bruna Paola Murino; Santos, Priscila P.; Fernandes, Ana Angélica Henrique; Okoshi, Katashi; Batista, Diego Felipe Alves; Modesto, Pamela; Gonçalves, Andréa; Pereira, Elenize Jamas; Pires, Vanessa; Paiva, Sérgio Alberto Rupp de; Zornoff, Leonardo A. M.; Azevedo, Paulo Furquim de

doi:10.1016/j.ijcard.2016.09.092

Cited by 23 publications

(19 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alterations in energy metabolism were also important mechanisms in the cardiac remodelling process induced by tobacco exposure. Under physiological conditions, free fatty acids are the main energy substrate of the heart, accounting for 60%‐90% of the energy supply . Fatty acids and glucose metabolites enter the citric acid cycle by β‐oxidation and glycolysis, respectively, to generate FADH2 and NADH, which participate in the electron transport chain.…”

Section: Discussionmentioning

confidence: 99%

Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke

Lourenço

Braz

Aun

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

The objective of this study was to investigate the influence of Spondias mombin (SM) supplementation on the cardiac remodelling process induced by exposure to tobacco smoke (ETS) in rats. Male Wistar rats were divided into 4 groups: group C (control, n = 20) comprised animals not exposed to cigarette smoke and received standard chow; group ETS (n = 20) comprised animals exposed to cigarette smoke and received standard chow; group ETS100 (n = 20) received standard chow supplemented with 100 mg/kg body weight/d of SM; and group ETS250 (n = 20) received standard chow supplemented with 250 mg/kg body weight/d of SM. The observation period was 2 months. The ETS animals had higher values of left cardiac chamber diameters and of left ventricular mass index. SM supplementation attenuated these changes. In addition, the myocyte cross‐sectional area (CSA) was lower in group C compared with the ETS groups; however, the ETS250 group had lower values of CSA compared with the ETS group. The ETS group also showed higher cardiac levels of lipid hydroperoxide (LH) compared with group C; and, groups ETS100 and ETS250 had lower concentrations of LH compared with the ETS group. Regarding energy metabolism, SM supplementation decreased glycolysis and increased the β‐oxidation and the oxidative phosphorylation. There were no differences in the expression of Nrf‐2, SIRT‐1, NF‐κB, interferon‐gamma and interleukin 10. In conclusion, our results suggest that ETS induced the cardiac remodelling process. In addition, SM supplementation attenuated this process, along with oxidative stress reduction and energy metabolism modulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke

Lourenço

Braz

Aun

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…To determine nuclear erithroid factor 2 (Nrf-2), LV samples were extracted with Nuclear Extraction Buffer[39]. The following primary antibodies were used: HO-1-1 to heme oxygenase-1; ab13248 (Abcam Inc, Cambridge); Nrf2: C-20, rabbit Immunoglobulin G (Santa Cruz Biotechnology Inc, Europe); Cleaved Caspase-3 (Asp175) (5A002E) Rabbit mAb (Cell Signalling Technology Inc., USA); Bcl2 sc 492 IgG rabbit monoclonal (Santa Cruz Biotechnology, Inc, Europe); and PGC-1α Antibody H-300: sc-13067 (Santa Cruz Biotechnology, Inc, Europe).…”

Section: Methodsmentioning

confidence: 99%

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundMyocardial infarction (MI) is one of the leading causes of morbidity and mortality worldwide. Dietary intervention on adverse cardiac remodeling after MI has significant clinical relevance. Rosemary leaves are a natural product with antioxidant/anti-inflammatory properties, but its effect on morphology and ventricular function after MI is unknown.Methods and resultsTo determine the effect of the dietary supplementation of rosemary leaves on cardiac remodeling after MI, male Wistar rats were divided into 6 groups after sham procedure or experimental induced MI: 1) Sham group fed standard chow (SR0, n = 23); 2) Sham group fed standard chow supplemented with 0.02% rosemary (R002) (SR002, n = 23); 3) Sham group fed standard chow supplemented with 0.2% rosemary (R02) (SR02, n = 22); 4) group submitted to MI and fed standard chow (IR0, n = 13); 5) group submitted to MI and fed standard chow supplemented with R002 (IR002, n = 8); and 6) group submitted to MI and fed standard chow supplemented with R02 (IR02, n = 9). After 3 months of the treatment, systolic pressure evaluation, echocardiography and euthanasia were performed. Left ventricular samples were evaluated for: fibrosis, cytokine levels, apoptosis, energy metabolism enzymes, and oxidative stress. Rosemary dietary supplementation attenuated cardiac remodeling by improving energy metabolism and decreasing oxidative stress. Rosemary supplementation of 0.02% improved diastolic function and reduced hypertrophy after MI. Regarding rosemary dose, 0.02% and 0.2% for rats are equivalent to 11 mg and 110 mg for humans, respectively.ConclusionOur findings support further investigations of the rosemary use as adjuvant therapy in adverse cardiac remodeling.

show abstract

“…Defined as genetic, morphological and biochemical changes in response to the determined injury, cardiac remodeling results in progressive ventricular dysfunction and death. Several factors are associated with cardiac remodeling after MI, and among them, we can highlight the increase in oxidative stress and the inflammatory process [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Tomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways

Pereira

Reis

Severino

et al. 2017

The Journal of Nutritional Biochemistry

Self Cite

View full text Add to dashboard Cite

The objective of this study was to evaluate the influence of tomato or lycopene supplementation on cardiac remodeling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16). After 3 months, morphological, functional and biochemical analyses were performed. The groups MIL and MIT showed decreased interstitial fibrosis induced by infarction. Tomato supplementation attenuated the hypertrophy induced by MI. In addition, tomato and lycopene improved diastolic dysfunction evaluated by echocardiographic and isolated heart studies, respectively. The MI group showed higher levels of cardiac TNF-α compared to the MIL and MIT groups. Decreased nuclear factor E2-related factor 2 was measured in the MIL group. Lipid hydroperoxide levels were higher in the infarcted groups; however, the MIT group had a lower concentration than did the MI group [S=223±20.8, MI=298±19.5, MIL=277±26.6, MIT=261±28.8 (nmol/g); n=8; P<.001]. We also examined left ventricle miRNA expression; when compared to the S group, the MIL group uniquely down-regulated the expression of eight miRNAs. No miRNA was found to be up-regulated uniquely in the MIT and MIL groups. In conclusion, tomato or lycopene supplementation attenuated the cardiac remodeling process and improved diastolic function after MI. However, the effect of lycopene and tomato supplementation occurred through different mechanistic pathways.

show abstract

Green tea (Cammellia sinensis) attenuates ventricular remodeling after experimental myocardial infarction

Abstract: GT attenuated cardiac remodeling after MI, associated with improvement in systolic and diastolic dysfunction. Oxidative stress, energy metabolism, apoptosis, and extracellular matrix alterations are all potential mechanisms by which GT may take part.

Cited by 23 publications

References 47 publications

Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke

Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke

Rosemary supplementation (Rosmarinus oficinallis L.) attenuates cardiac remodeling after myocardial infarction in rats

Tomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways

Contact Info

Product

Resources

About