Familial Brain Periventricular Pseudocysts

Shinar, Shiri; Malinger, G.; Leibovitz, Z.; Ben-Sira, Liat; Leshinsky‐Silver, Esther; Gindes, L.; Lerman‐Sagie, Tally; Kidron, Dvora; Lev, Dorit

doi:10.1159/000448951

Cited by 4 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That is why depending on available local expertise, fetal MRI can be done to evaluate this finding carefully for confirming the diagnosis and evaluating the presence of other CNS abnormalities 49 . Moreover, they should also be evaluated for other abnormalities, such as genetic disorders and chromosomal syndromes, metabolic diseases, cardiovascular abnormalities, as well as infections (Cytomegalovirus [CMV]) 50 . Periventricular pseudocysts (PVPCs) are cystic cavities without the ependymal cell lining that real cysts have.…”

Section: Developmental Cystic Lesionsmentioning

confidence: 99%

Ultrasound and magnetic resonance imaging features of fetal intracranial cystic lesions: A pictorial essay

Moradi

Golezar

Gargari

et al. 2022

J of Clinical Ultrasound

View full text Add to dashboard Cite

This pictorial essay focuses on ultrasound (US) and magnetic resonance imaging (MRI) features of fetal intracranial cysts. Intracranial cysts are common findings in prenatal imaging, and if great attention is paid to their size, location, and imaging features, they can be diagnosed accurately. They are usually detected by fetal ultrasound exams. However, when ultrasound data on cystic lesion characteristics is insufficient, MRI and fetal neurosonogram are the best options for detecting other associated anomalies. The prognosis is highly dependent on their location and whether they are associated with other fetal anomalies.

show abstract

Section: Developmental Cystic Lesionsmentioning

confidence: 99%

Ultrasound and magnetic resonance imaging features of fetal intracranial cystic lesions: A pictorial essay

Moradi

Golezar

Gargari

et al. 2022

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

“…Periventricular pseudocysts (PVPCs) are cystic cavities that lack the ependymal cell lining found in true cysts (1)(2)(3)(4). PVPCs are thought to be the result of antenatal cystic germinal matrix regression or congenital viral infection, hemorrhage, or infarction (2,5,6).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of MRI Features and Neurodevelopmental Outcomes for Prenatally Diagnosed Periventricular Pseudocysts

et al. 2021

View full text Add to dashboard Cite

Objectives: This study aimed to evaluate the morphologic features and neurodevelopmental outcomes of individuals prenatally diagnosed with a periventricular pseudocyst (PVPC).Methods: Pregnant women with a fetus prenatally diagnosed with PVPC by MRI were enrolled in this retrospective study. The fetuses with PVPCs were divided into group 1 (isolated PVPC) and group 2 (PVPC with additional findings). The surviving infants underwent brain MRI examinations and the Gesell Developmental Scale (GDS) test after birth. Independent sample t-tests were used to compare the differences in the developmental quotient (DQ) between group 1 and group 2. We also analyzed the correlations among the DQ, location (unilateral/bilateral), size (diameter), and number (single/multiple) of the PVPCs in group 1 using Lasso regression.Results: In total, 131 infants (group 1: 78 infants, group 2: 53 infants) underwent MRI examinations after birth, and 97 infants (group 1: 59 infants, group 2: 38 infants) underwent the GDS test. Upon follow-up, the sizes of the cysts had become smaller or disappeared after birth. The average DQ in group 2 was lower than that in group 1 (all with p < 0.001). In group 1, the location (unilateral/bilateral), size (diameter), and number (single/multiple) of the PVPC did not affect the DQ.Conclusions: The PVPCs became smaller or disappeared after birth. Isolated PVPCs usually have a normal presentation after birth regardless of the location, number, or size. For PVPCs with additional findings, the neurodevelopmental outcomes were inferior to those in isolated PVPCs.

show abstract

Periventricular pseudocysts of noninfectious origin: Prenatal associated findings and prognostic factors

et al. 2020

View full text Add to dashboard Cite

ObjectiveThe purpose of this study was to establish prognostic factors in fetuses diagnosed with periventricular pseudocysts (PVPCs) without known congenital infection, between 28 and 37 weeks of gestation.MethodsThis retrospective study included cases of fetal PVPC from 2008 to 2018. PVPCs were classified according to location, number, extension, morphology, and size. Additional findings, MRI and genetic studies were recorded. Pregnancy outcome, postnatal, or postmortem results were obtained. Images from patients with normal (Group 1) and abnormal postnatal development (Group 2) were compared for analysis of factors predictive of outcome.ResultsOne‐hundred and fifteen pseudocysts were observed in 59 patients. In 34 fetuses (57%), the PVPC was an isolated finding. Thirty‐nine patients delivered live newborns, 27% opted for termination of pregnancy, and 4 patients were lost to follow‐up. Eighty‐four percent of the liveborns had normal development. When assessing for the influence of pseudocyst characteristics, a wide CSP, or large head circumference, neither of these affected the outcome. The presence of additional anomalies was the only positive predictor for abnormal development regradless of specific PVPC characteristics (P = .002).ConclusionsIn fetuses with PVPCs, the presence of additional anomalies was the only predictor for adverse postnatal outcome. No association between cystic characteristics and adverse outcome was observed.

show abstract

Familial Brain Periventricular Pseudocysts

Cited by 4 publications

References 22 publications

Ultrasound and magnetic resonance imaging features of fetal intracranial cystic lesions: A pictorial essay

Ultrasound and magnetic resonance imaging features of fetal intracranial cystic lesions: A pictorial essay

Evaluation of MRI Features and Neurodevelopmental Outcomes for Prenatally Diagnosed Periventricular Pseudocysts

Periventricular pseudocysts of noninfectious origin: Prenatal associated findings and prognostic factors

Contact Info

Product

Resources

About