Erratum: Trajectories of adolescent conduct problems in relation to cortical thickness development: a longitudinal MRI study

Oostermeijer, S; Whittle, S; Suo, C; Allen, N B; Simmons, Julian G; Vijayakumar, N; Ven, Peter M. van de; Jansen, L M C; Yücel, M; Popma, A

doi:10.1038/tp.2016.134

Cited by 6 publications

(1 citation statement)

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“…Indeed, the presence of neurodevelopmental abnormalities, notably involving cortical regions, is associated with an increased lifetime risk for depression [ 54 ]. The establishment of cortical thickness depends on different processes such as cell death, synaptogenesis, synaptic pruning, and myelination during the first two decades of life, with a dynamic synaptic reorganization modulated by environmental influences [ 57 , 58 , 59 , 60 ]. Abnormal brain volume has been consistently shown in depression, and a recent meta-analysis including over 10,000 subjects showed cortical abnormalities in adults and adolescents with major depression [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling in Huntington’s Disease: Does Comorbidity with Depressive Symptoms Matter?

Colpo

Rocha

Stimming

et al. 2020

IJMS

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Huntington’s disease (HD) is an inherited neurodegenerative disease. Besides the well-characterized motor symptoms, HD is marked by cognitive impairment and behavioral changes. In this study, we analyzed the blood of HD gene carries using RNA-sequencing techniques. We evaluated samples from HD gene carriers with (n = 8) and without clinically meaningful depressive symptoms (n = 8) compared with healthy controls (n = 8). Groups were age- and sex-matched. Preprocessing of data and between-group comparisons were calculated using DESeq2. The Wald test was used to generate p-values and log2 fold changes. We found 60 genes differently expressed in HD and healthy controls, of which 21 were upregulated and 39 downregulated. Within HD group, nineteen genes were differently expressed between patients with and without depression, being 6 upregulated and 13 downregulated. Several of the top differentially expressed genes are involved in nervous system development. Although preliminary, our findings corroborate the emerging view that in addition to neurodegenerative mechanisms, HD has a neurodevelopmental component. Importantly, the emergence of depression in HD might be related to these mechanisms.

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