Aberrant cortical neurodevelopment in major depressive disorder

Schmitgen, Mike M.; Depping, Malte S.; Bach, Claudia; Wolf, Nadine D.; Kubera, Katharina M.; Vasić, Nenad; Hirjak, Dušan; Sambataro, Fabio; Wolf, Robert Christian

doi:10.1016/j.jad.2018.09.021

Cited by 45 publications

(47 citation statements)

References 60 publications

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“…Although the link between LGI in stress‐associated cluster was only associated with POMS at a trend‐level after FDR correction ( p FDR = .084), a vertex‐wise analysis with POMS, showed substantial overlap in the temporal lobe clusters wherein greater gyrification was independently associated with prenatal stress and mood disturbance. These findings are partly consistent with previous research which found greater gyrification of the temporal cortex, as well as other regions, in patients with generalized anxiety disorder (Molent et al, 2018) and major depressive disorder (Schmitgen et al, 2019). Taken together, these findings suggest that altered gyrification in the temporal lobe may link early life stress to potentially elevated risk of mood disorders in adult females.…”

Section: Discussionsupporting

confidence: 92%

“…Notably, however, findings in major depressive disorder (MDD) are more mixed. While some studies did not find any differences in gyrification between MDD and healthy controls (HC) (Cao et al, 2017), others reported both higher (Han et al, 2017; Peng et al, 2015; Schmitgen et al, 2019), and lower (Depping et al, 2018; Nixon et al, 2014; Zhang et al, 2009) gyrification across different brain regions in MDD as compared to HC. Depping et al (Depping et al, 2018) also demonstrated common and distinct patterns of LGI alterations across MDD and BD, suggesting that, rather than being disease‐specific, some LGI abnormalities may mediate broader developmental vulnerability to disorders of emotion (Depping et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Marečková

Miles

Andrýsková

et al. 2020

Human Brain Mapping

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Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23–24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6–18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex‐specificity of effects. In particular, whereas early prenatal stress was associated with sex‐dependent medium‐to‐large effects in large temporal, parietal, and occipital regions (f2 = 0.19–0.38, p < .001), later perinatal stress was associated with sex‐independent small‐to‐medium effects in smaller, more anterior regions (f2 = 0.10–0.19, p < .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r = 0.399, p = .006). These findings point out the long‐term implications of perinatal stress exposure for cortical morphology and mood dysregulation.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Marečková

Miles

Andrýsková

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

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“…Thus, LGI is the most ideal method to investigate the abnormal neurodevelopmental patterns in MDD. With LGI method, some studies have found the changed LGI in MDD compared to healthy controls (25)(26)(27). Schmitgen et al (27) found significantly greater LGI in frontal, cingulate, parietal, temporal, and occipital regions in MDD patients.…”

Section: Introductionmentioning

confidence: 99%

“…With LGI method, some studies have found the changed LGI in MDD compared to healthy controls (25)(26)(27). Schmitgen et al (27) found significantly greater LGI in frontal, cingulate, parietal, temporal, and occipital regions in MDD patients. Han et al (26) found increased LGI in rostral anterior cingulate cortex, medial orbitofrontal cortex and frontal pole in MDD patients using region of interest analysis.…”

Section: Introductionmentioning

confidence: 99%

Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder

Long

Wang

et al. 2020

Front. Psychiatry

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A lot of previous studies have documented that major depressive disorder (MDD) is a developmental disorder. The cortical surface measure, local gyrification index (LGI), can well reflect the fetal and early postnatal neurodevelopmental processes. Thus, LGI may provide new insight for the neuropathology of MDD. The previous studies only focused on the surface structural abnormality, but how the structural abnormality lead to functional connectivity changes is unexplored. In this study, we investigated LGI and corresponding functional connectivity difference in 28 medication-free MDD patients. We found significantly decreased LGI in left lingual gyrus (LING) and right posterior superior temporal sulcus (bSTS), and the changed LGI in bSTS was negatively correlated with disease onset age and anxiety scores. The following functional connectivity analyses identified decreased functional connectivities between LING and right LING, precentral gyrus, and middle temporal gyrus. The decreased functional connectivities were correlated with disease duration, onset, and depression symptoms. Our findings revealed abnormal LGI in LING and bSTS indicating that the abnormal developmental of visual and social cognition related brain areas may be an early biomarker for depression.

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“…30 However, previous magnetic resonance imaging (MRI) studies have considered relatively modest sample sizes (10-15 catatonia patients) and the vast majority of MRI studies focused on aberrant activation of cortical regions neglecting the fact that catatonia in SSD is based on intertwined mosaic of genetic and environmental factors. [30][31][32][33][34][35][36][37][38] A promising approach to study the neurodevelopmental nature of catatonia is to examine measures of cortical organization separately affected by neurodevelopment such as cortical thickness, area, and local gyrification index (LGI). The aims of this study were to determine which cortical features of distinct neurodevelopmental and genetic origin (cortical thickness, area, and LGI) are specific for SSD with catatonia as distinguished from SSD without catatonia.…”

Section: Introductionmentioning

confidence: 99%

Cortical Contributions to Distinct Symptom Dimensions of Catatonia

Hirjak

Kubera

Northoff

et al. 2019

Schizophrenia Bulletin

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Catatonia is a central aspect of schizophrenia spectrum disorders (SSD) and most likely associated with abnormalities in affective, motor, and sensorimotor brain regions. However, contributions of different cortical features to the pathophysiology of catatonia in SSD are poorly understood. Here, T1-weighted structural magnetic resonance imaging data at 3 T were obtained from 56 right-handed patients with SSD. Using FreeSurfer version 6.0, we calculated cortical thickness, area, and local gyrification index (LGI). Catatonic symptoms were examined on the Northoff catatonia rating scale (NCRS). Patients with catatonia (NCRS total score ≥3; n = 25) showed reduced surface area in the parietal and medial orbitofrontal gyrus and LGI in the temporal gyrus (P < .05, corrected for cluster-wise probability [CWP]) as well as hypergyrification in rostral cingulate and medial orbitofrontal gyrus when compared with patients without catatonia (n = 22; P < .05, corrected for CWP). Following a dimensional approach, a negative association between NCRS motor and behavior scores and cortical thickness in superior frontal, insular, and precentral cortex was found (34 patients with at least 1 motor and at least 1 other affective or behavioral symptom; P < .05, corrected for CWP). Positive associations were found between NCRS motor and behavior scores and surface area and LGI in superior frontal, posterior cingulate, precentral, and pericalcarine gyrus (P < .05, corrected for CWP). The data support the notion that cortical features of distinct evolutionary and genetic origin differently contribute to catatonia in SSD. Catatonia in SSD may be essentially driven by cortex variations in frontoparietal regions including regions implicated in the coordination and goal-orientation of behavior.

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Aberrant cortical neurodevelopment in major depressive disorder

Cited by 45 publications

References 60 publications

Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Temporally and sex‐specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder

Cortical Contributions to Distinct Symptom Dimensions of Catatonia

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