Flavonoids, gallotannins and ellagitannins in Syzygium guineense and the traditional use among Malian healers

Nguyen, Thuy Lan; Rusten, Anders; Bugge, Mona Skogsrud; Malterud, Karl Egil; Diallo, Drissa; Paulsen, Berit Smestad; Wangensteen, Helle

doi:10.1016/j.jep.2016.09.035

Cited by 32 publications

(26 citation statements)

References 42 publications

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“…3 Phytochemical constituents [46,47], 2′,4′-dihydroxy-6′-methoxy-3′-methylchalcone or stercurensin (7), 2′-hydroxy-4′,6′-dimethoxy-3′-methylchalcone (8) [46,47], 2′,4′-dihydroxy-6′-methoxy-3′,5′dimethylchalcone (9) [44], 2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (10), 2′,4′-dihydroxy-6′-methoxchalcone or cardamonin (11) [51], pinocembrin (12), (−)-strobopinin (13), 8methylpinocembrin (14), demethoxymatteutcinol (15), 7hydroxy-5-methoxy-6,8-dimethylfoavanone (16) [48], 7,8,3′,4′-tetrahydroxy-3,5-dimethoxyflavone (17) [45], 7-hydroxy-5-methoxy-6,8-dimethylflavanone (18), quercetin (19) [49,50], kaempferol (20) [54], gallocatechin (21), myricetin…”

Section: Syzygium Guineensementioning

confidence: 99%

“…Tannins 3,3′,4′-Tri-O-methylellagic acid (87)[55], ellagic acid (88)[49,64], ellagitannin-3-O-methylellagic acid 3′-O-β-D-glucopyranoside (89), ellagic acid 4-O-α-L-2″-acetylhamnopyranoside (90) [64], 3-O-methylellgic acid 3′-Oα-L-rhamnopyranoside (91), gallotannins 1,2,3,6-tetra-Ogalloyl-β-D-glucose (92), 1,2,3,4,6-penta-O-galloyl-β-Dglucose (93), casuarictin (94) and casuarinin (95)[51] are depicted inFigure 7.…”

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confidence: 99%

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Plant description, phytochemical constituents and bioactivities of Syzygium genus: A review

et al. 2020

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This article attempts to report native growth, plant description, phytochemical constituents and bioactivities of Syzygium aqueum, S. aromaticum, S. cumini, S. guineense and S. samarangense. Those are the large public species in the Syzygium genus and some of them have been used as traditional medicines. Different parts (leaves, seeds, fruits, barks, stem barks and flower buds) of each species plant are rich in phytochemical constituents such as flavonoids, terpenoids, tannins, glycosides and phenolics. Antioxidant, antidiabetic, anticancer, toxicity, antimicrobial, anti-inflammatory and anthelmintic activities are reported in various extracts (methanol, ethanol and aqueous) from different parts of Syzygium sp. The bioactivities were studied by using 1,1-diphenyl-2-picrylhydrazyl and ferric reducing antioxidant power assays for antioxidant, 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethyl-thiazoly)-3-(4-sulfophenyl) tetrazolium and 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assays for anticancer, α-glucosidase and α-amylase inhibition assays for antidiabetic, agar well diffusion method for antimicrobial and brine shrimp lethality assay for toxicity. Moreover, this review shows that phytochemical constituents of each species significantly presented various bioactivities. Therefore, this review suggests that there is great potential for obtaining the lead drug from these species.

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Section: Syzygium Guineensementioning

confidence: 99%

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confidence: 99%

Plant description, phytochemical constituents and bioactivities of Syzygium genus: A review

et al. 2020

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“…Erythrina abyssinica HIV/AIDS (Lamorde et al, 2010), vomiting (Tugume et al, 2016); Burundi: cough (Rodegem, 1970), eyes, strenghtens breastmilk, female sterility, cough, epistaxis, depression, protection black magic (Baerts and Lehmann, 1989); central Africa: stomach problems (Balagizi et al, 1998); Congo: eye inflammation, snake bitse, antihelmentic, diphtheria (Defour, 1994), tuberculosis, eye inflammation (Cihyoka, 1994), wounds (Byavu et al, 2000, hemorrhoids (Nyakabwa and Dibaluka, 1990); Kenya: wounds, dermatosis, boils (Kokwaro, 1987), internal pain (Glover et al, 1966); Kenya/Uganda/Tanzania: snake bite, gonorrhea, syphilis, collique, stomach ache (Kokwaro, 1976); Rwanda: eye inflammation (Desouter, 1991), wounds, snake bites, lepre (Durand, 1960), dysentery, meningitis, jaundice Habiyaremye, 1987), hemorrhoids (Ayobangira et al, 2000); Tanzania: stomach pain (Chabra et al, 1990); Uganda: candide (Hamil et al, 2000), epilepsy (Adjanohoun et al, 1993); Zimbabwe: cough, rougeole, bilharziose, cachexie, psychose (Gelfand et al, 1985) Anticancer (Samanga et al, 2014), wound healing properties (Marume et al, 2017), prevents meningoencephalitis (Nasimolo et al, 2014), antimicrobial (Kamat et al, 1981), antibacterial (Nguyen et al, 2016;Wagate et al, 2010), antimalariall (Yenesew et al, 2004), antihyperglycemic (Amuri et al, 2017), anti-HIV, antiviral (Mohammed et al, 2012), antidiabetic (Cui et al, 2010, antifungal (Manyarara et al, 2016) cytotoxic (Perez et al, 2015), antimycobacterial (Bunalema et al, 2011)…”

Section: Englerophytum Magalismontanummentioning

confidence: 99%

Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola

Novotná

Polesny

Pinto-Basto

et al. 2020

Journal of Ethnopharmacology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…3A), suggesting that the active component is hydrophilic. Since polyphenols, predominantly tannins, are abundant in S. guineense [30,44], we analyzed the phenolic content in these two extracts, and indeed found that the water extract was more richer phenolic compounds than the ethanol extract (Fig. 3B).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 97%

“…Several examples of polyphenolic compounds inhibiting the Wnt pathway at different levels of the pathway have been described [31][32][33][34]61]. Of those, analysis of the effects of tannins [61] is particularly relevant to our study, given the high abundance of tannins in S. guineense [30,44].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts

et al. 2018

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Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required to develop drugs against these and other Wnt-dependent cancers. Natural products, especially plants, have been used for the treatment of various diseases from ancient times. We examined extracts from several indigenous Cameroonian herbs and tested their effects on proliferation and Wnt signaling in TNBC and CC cells. Extracts from "fruit rouge", Syzygium guineense Wall. (Myrtaceae), demonstrated a strong activity against these cancer cells, as well as CC organoids. We found TNBC cells to significantly upregulate expression of Wnt3a, and the effects of S. guineense extracts on TNBC cell proliferation correlated with inhibition of the Wnt3a-induced β-catenin stabilization and transcriptional response. HPLC analysis revealed that the active components belong to tannins. We found a direct destabilizing effect of S. guineense extract on Wnt3a and other Wnt proteins, identifying a novel mechanism of action of tannins on the Wnt signaling pathway and cancer cell proliferation. Being edible, this African plant may have an important cancer-preventive nutritional value.

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Flavonoids, gallotannins and ellagitannins in Syzygium guineense and the traditional use among Malian healers

Cited by 32 publications

References 42 publications

Plant description, phytochemical constituents and bioactivities of Syzygium genus: A review

Plant description, phytochemical constituents and bioactivities of Syzygium genus: A review

Medicinal plants used by ‘root doctors’, local traditional healers in Bié province, Angola

Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts

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