This article attempts to report native growth, plant description, phytochemical constituents and bioactivities of Syzygium aqueum, S. aromaticum, S. cumini, S. guineense and S. samarangense. Those are the large public species in the Syzygium genus and some of them have been used as traditional medicines. Different parts (leaves, seeds, fruits, barks, stem barks and flower buds) of each species plant are rich in phytochemical constituents such as flavonoids, terpenoids, tannins, glycosides and phenolics. Antioxidant, antidiabetic, anticancer, toxicity, antimicrobial, anti-inflammatory and anthelmintic activities are reported in various extracts (methanol, ethanol and aqueous) from different parts of Syzygium sp. The bioactivities were studied by using 1,1-diphenyl-2-picrylhydrazyl and ferric reducing antioxidant power assays for antioxidant, 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethyl-thiazoly)-3-(4-sulfophenyl) tetrazolium and 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assays for anticancer, α-glucosidase and α-amylase inhibition assays for antidiabetic, agar well diffusion method for antimicrobial and brine shrimp lethality assay for toxicity. Moreover, this review shows that phytochemical constituents of each species significantly presented various bioactivities. Therefore, this review suggests that there is great potential for obtaining the lead drug from these species.

A large common species, Syzygium aqueum, belonging to the genus Syzygium possesses numerous bioactive phytochemical constituents. Moreover, the different parts of this species have been used as folk medicine since centuries ago. In this study, a phytochemical exploration was carried out on the plant’s stem bark. Isolation of the compounds was carried out through the extraction step with some organic solvents, followed by separation and purification using chromatography techniques until the two triterpenoids were isolated from nonpolar and semipolar extracts. Structure elucidation was done using spectroscopic methods. These compounds were identified as alphitolic acid and arjunolic acid. Subsequently, these two compounds were used in anticancer tests against human cancer cells HeLa, T47D, and A549 using colorimetric assay. The result showed that both compounds showed more inhibition of the growth of HeLa and T47D than A549 cancer cells, with the highest activity shown by arjunolic acid against HeLa cell lines.

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Syzygium genus in Myrtaceae family is a rich source of phytochemical constituents that possess various bioactivities. One of well-known species of this genus, Syzygium aqueum, has been already utilized as traditional medicine. This plant is cultivated in countries of tropical regions of the world such as Malaysia and Indonesia. The aim of this study was intended to isolate phytochemical constituents from the stem bark of S. aqueum. To date, there have been no reports of chemical substances isolated from the stem bark of this plant. The powder of the stem bark was extracted followed by partitioned in order to obtain n-hexane extract which then was separated using silica gel column chromatographic several times until the pure compounds were resulted. The isolated compounds were identified by spectroscopie method including Fouirer Transform Infrared (FTIR) and nuclear magnetic resonance (NMR) and were known as 2,4-Di-tert-butylphenol & butyrospermol 3-β-O-palmitate, respectively. The spectoscopie data of those compounds were compared with references.

We presented pharmacokinetic study, molecular docking, and MD simulation to study β-sitosterol and oleanolic acid compounds and potential HSD17B1 inhibitors.

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