Size effect of SnO 2  nanoparticles on bacteria toxicity and their membrane damage

Chávez-Calderón, Adriana; Paraguay‐Delgado, F.; Orrantia‐Borunda, Erasmo; Luna-Velasco, Antonia

doi:10.1016/j.chemosphere.2016.09.003

Cited by 42 publications

(13 citation statements)

References 29 publications

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“…This poor solubility is in agreement with the data described in the literature. In fact, the amount of metal(loid)s released from the NPs, here presented, is of the same order of magnitude of the values reported for In 2 O 3 (Bomhard 2018;Jeong et al 2016), Mn 3 O 4 (Ivask et al 2015), SiO 2 (Van Hoecke et al 2008) and SnO 2 NPs (Chavez-Calderon et al 2016).…”

Section: Discussionsupporting

confidence: 85%

“…Other studies showed that Al 2 O 3 , Mn 3 O 4 and SiO 2 NPs caused growth inhibition of bacteria (Escherichia coli and Staphylococcus aureus), algae (Pseudokirchneriella subcapitata) and protozoa (Tetrahymena thermophila and Paramecium multimicronucleatum) and bioluminescence reduction of the bacterium Vibrio fischeri (Aruoja et al 2015;Li et al 2012). SnO 2 NPs caused a reduction of cell viability and provoked the damage of cell membrane in the bacteria E. coli and Bacillus subtilis (Chavez-Calderon et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…SiO 2 NPs present unique properties, such as mechanical, catalytic, magnetic and optical properties, which lead them to be used in paints, plastic, ceramics, batteries and cosmetics (Report 2018). Due to their semiconductor, electronic, optical and catalytic properties, SnO 2 NPs can be used in a variety of applications in the industry, such as solar cells, photo catalysis and sensors (Chavez-Calderon et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…The increasing use of MOx NPs leads, inevitably, to an augmented concern related to its possible toxicity. Studies in soils showed that Al 2 O 3 , SiO 2 and SnO 2 NPs had an impact in bacterial and in fungal community (Chai et al 2015;Chavez-Calderon et al 2016;McGee et al 2017). Other studies showed that Al 2 O 3 , Mn 3 O 4 and SiO 2 NPs caused growth inhibition of bacteria (Escherichia coli and Staphylococcus aureus), algae (Pseudokirchneriella subcapitata) and protozoa (Tetrahymena thermophila and Paramecium multimicronucleatum) and bioluminescence reduction of the bacterium Vibrio fischeri (Aruoja et al 2015;Li et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Metal(loid) oxide (Al2O3, Mn3O4, SiO2 and SnO2) nanoparticles cause cytotoxicity in yeast via intracellular generation of reactive oxygen species

Sousa

Soares

2019

Appl Microbiol Biotechnol

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In this work, the physicochemical characterization of five (Al 2 O 3 , In 2 O 3 , Mn 3 O 4 , SiO 2 and SnO 2) nanoparticles (NPs) was carried out. In addition, the evaluation of the possible toxic impacts of these NPs and the respective modes of action were performed using the yeast Saccharomyces cerevisiae. In general, in aqueous suspension, metal(loid) oxide (MOx) NPs displayed an overall negative charge and agglomerated; these NPs were practically insoluble (dissolution < 8%) and did not generate detectable amounts of reactive oxygen species (ROS) under abiotic conditions. Except In 2 O 3 NPs, which did not induce an obvious toxic effect on yeast cells (up to 100 mg/L), the other NPs induced a loss of cell viability in a dose-dependent manner. The comparative analysis of the loss of cell viability induced by the NPs with the ions released by NPs (NPs supernatant) suggested that SiO 2 toxicity was mainly caused by the NPs themselves, Al 2 O 3 and SnO 2 toxic effects could be attributed to both the NPs and the respective released ions and Mn 3 O 4 harmfulness could be mainly due to the released ions. Al 2 O 3 , Mn 3 O 4 , SiO 2 and SnO 2 NPs induced the loss of metabolic activity and the generation of intracellular ROS without permeabilization of plasma membrane. The co-incubation of yeast cells with MOx NPs and a free radical scavenger (ascorbic acid) quenched intracellular ROS and significantly restored cell viability and metabolic activity. These results evidenced that the intracellular generation of ROS constituted the main cause of the cytotoxicity exhibited by yeasts treated with the MOx NPs. This study highlights the importance of a ROS-mediated mechanism in the toxicity induced by MOx NPs.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metal(loid) oxide (Al2O3, Mn3O4, SiO2 and SnO2) nanoparticles cause cytotoxicity in yeast via intracellular generation of reactive oxygen species

Sousa

Soares

2019

Appl Microbiol Biotechnol

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“…Other groups have suggested that their intrinsic ability to produce ROS (which may arise from surface defects, such as oxygen vacancies) is responsible for the high cytotoxic potential of ZnO NPs [ 24 , 25 ]. In the same line, SnO 2 NPs have been shown to inhibit kinetic growth and cytotoxicity towards certain cell lines and organisms [ 18 , 26 , 27 ], while other publications have demonstrated modest to no cytotoxic effects [ 28 , 29 ]. Similar to other NPs, the crystal and hydrodynamic size of SnO 2 NPs play an important role on their toxic effects, and smaller sizes have been shown to correlate with increased toxicity [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

ZnO nanoparticles modulate the ionic transport and voltage regulation of lysenin nanochannels

et al. 2017

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BackgroundThe insufficient understanding of unintended biological impacts from nanomaterials (NMs) represents a serious impediment to their use for scientific, technological, and medical applications. While previous studies have focused on understanding nanotoxicity effects mostly resulting from cellular internalization, recent work indicates that NMs may interfere with transmembrane transport mechanisms, hence enabling contributions to nanotoxicity by affecting key biological activities dependent on transmembrane transport. In this line of inquiry, we investigated the effects of charged nanoparticles (NPs) on the transport properties of lysenin, a pore-forming toxin that shares fundamental features with ion channels such as regulation and high transport rate.ResultsThe macroscopic conductance of lysenin channels greatly diminished in the presence of cationic ZnO NPs. The inhibitory effects were asymmetrical relative to the direction of the electric field and addition site, suggesting electrostatic interactions between ZnO NPs and a binding site. Similar changes in the macroscopic conductance were observed when lysenin channels were reconstituted in neutral lipid membranes, implicating protein-NP interactions as the major contributor to the reduced transport capabilities. In contrast, no inhibitory effects were observed in the presence of anionic SnO2 NPs. Additionally, we demonstrate that inhibition of ion transport is not due to the dissolution of ZnO NPs and subsequent interactions of zinc ions with lysenin channels.ConclusionWe conclude that electrostatic interactions between positively charged ZnO NPs and negative charges within the lysenin channels are responsible for the inhibitory effects on the transport of ions. These interactions point to a potential mechanism of cytotoxicity, which may not require NP internalization.Electronic supplementary materialThe online version of this article (10.1186/s12951-017-0327-9) contains supplementary material, which is available to authorized users.

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Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

et al. 2019

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201904106.Bacterial infection is one of the top ten leading causes of death globally and the worst killer in low-income countries. The overuse of antibiotics leads to ever-increasing antibiotic resistance, posing a severe threat to human health. Recent advances in nanotechnology provide new opportunities to address the challenges in bacterial infection by killing germs without using antibiotics. Antibiotic-free antibacterial strategies enabled by advanced nanomaterials are presented. Nanomaterials are classified on the basis of their mode of action: nanomaterials with intrinsic or light-mediated bactericidal properties and others that serve as vehicles for the delivery of natural antibacterial compounds. Specific attention is given to antibacterial mechanisms and the structureperformance relationship. Practical antibacterial applications employing these antibiotic-free strategies are also introduced. Current challenges in this field and future perspectives are presented to stimulate new technologies and their translation to fight against bacterial infection.

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Size effect of SnO 2 nanoparticles on bacteria toxicity and their membrane damage

Cited by 42 publications

References 29 publications

Metal(loid) oxide (Al2O3, Mn3O4, SiO2 and SnO2) nanoparticles cause cytotoxicity in yeast via intracellular generation of reactive oxygen species

Metal(loid) oxide (Al2O3, Mn3O4, SiO2 and SnO2) nanoparticles cause cytotoxicity in yeast via intracellular generation of reactive oxygen species

ZnO nanoparticles modulate the ionic transport and voltage regulation of lysenin nanochannels

Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

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