Non-HDL-C is a Better Predictor for the Severity of Coronary Atherosclerosis Compared with LDL-C

Zhang, Yan; Wu, Na‐Qiong; Li, Sha; Zhu, Cheng‐Gang; Guo, Yuan‐Lin; Peng, Qing; Gao, Ying; Li, Xin; Geng, Long; Dong, Qian; Li, Jianjun

doi:10.1016/j.hlc.2016.04.025

Cited by 48 publications

(37 citation statements)

References 17 publications

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“…In the present study, we did not find the association between non-HDL-C level and carotid atherosclerosis in male as the previous studies reported [27, 28]. Our study showed that non-HDL-C levels are better targets compared with other lipid profiles in female subjects, which presented as a stronger linear relationship with increased CIMT and a more powerful discriminatory ability for carotid plaque prediction.…”

Section: Discussioncontrasting

confidence: 71%

Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Hao

et al. 2017

Lipids Health Dis

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BackgroundWe investigate whether non–high-density lipoprotein cholesterol (non-HDL-C) provides a better estimate of cardiovascular risk than other lipid profiles in normotensive and euglycemic middle-aged and elderly adults.MethodsA total of 512 males and 958 females were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral carotid intima-media thicknesses (CIMTs) were measured using ultrasonography, and the presence of carotid plaques was assessed.ResultsThe mean values of non-HDL-C were 3.4 ± 0.8 mmol/l and 3.6 ± 0.9 mmol/l for male and female subjects, respectively. Compared with female subjects with non-HDL-C in the first quartile, female subjects with non-HDL-C in the fourth quartile had 1.317-fold increased risks for carotid plaques after adjusting for conventional cardiovascular disease (CVD) risk factors and increasing quartiles of all lipid levels. Non-HDL-C was positively associated with the CIMT after adjusting for CVD risk factors in female subjects (β = 0.062, P = 0.034).ConclusionsThese results suggest that non-HDL-C is independently associated with carotid atherosclerosis in normotensive and euglycemic females.

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Section: Discussioncontrasting

confidence: 71%

Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Hao

et al. 2017

Lipids Health Dis

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“…Therefore, the ApoB evaluation could work as a direct proxy when assessing the number of atherogenic particles (LDL and non-LDL). Non-HDL-c has also been suggested as a better marker of CVD risk and coronary atherosclerosis (18) and non-HDL lipoproteins, were associated with atherogenic dyslipidemia, insulin resistance, portal hyperinsulinemia and the metabolic syndrome phenotype (15,17,(19)(20)(21)(22)(23). Patients with higher levels of triglycerides were shown to have lower LDL-c levels for any given ApoB concentration compared with subjects with lower levels of triglycerides by Leroux et al (24).…”

Section: Resultsmentioning

confidence: 99%

Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol

Fonseca

Paredes

Ramos

et al. 2020

Preprint

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Purpose: Lipid-lowering therapy is guided by Low-density-lipoprotein cholesterol (LDL-c), although the CVD risk could be better reflected by other lipid parameters. This study aimed the evaluation of a comprehensive lipid profile in patients with type 2 diabetes mellitus (T2DM) and comparation of those achieving and not achieving LDL-c control in respect to other non-conventional lipid parameters. Methods: We characterized a comprehensive lipid profile in 96 T2DM patients. ESC/EAS 2016 and 2019 Guidelines for the Management of Dyslipidemias were used to define LDL-c targets. Atherogenic lipoprotein profile was compared in patients with LDL-c within and above the target. Results: Only 28.1% and 16.7% of patients had mean LDL-c levels within the 2016 and 2019 guidelines, respectively. In patients with LDL-c within target by the 2016 guidelines, 22%, 25% and 44% presented levels above the recommended range for non-HDL-c, ApoB and oxidized LDL-c, respectively, whereas accordingly to the 2019 guidelines, 50%, 39% and 44% had elevated levels of -HDL-c, ApoB and oxidized LDL-c, respectively. There was a significant strong association of LDL-c and non-HDL-c (r=0.850), ApoB (r=0.656) and oxidized LDL-c (r=0.508). Similarly, non-HDL-c was significantly strongly correlated with ApoB (r=0.808) and oxidized LDL-c (r=0.588). Conclusions: These findings emphasize the limitations of a sole LDL-c measurement for CV risk assessment. Targeting only LDL-c could result in missed opportunities for CV risk reduction in T2DM individuals. Our data suggest that non-HDL-c, ApoB and oxidized LDL-c could be considered as part of these patients’ evaluation allowing a more accurate estimation of CV risk and treatment among these high-risk patients.

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“…The atherogenic index (AI), which is calculated as AI = (TC-HDL-C)/HDL-C, was used first to estimate the status of blood lipids [20]. Subsequently, the use of AI to assess plasma (AIP; calculated as Log10(TG/HDL-C)) [22], non-high-density lipoprotein, (non-HDL-C; calculated as TC -HDL-C) [19,23] and TC/HDL-C was proposed. The aim of the current study was (1) to explore the association among blood lipid and arterial stiffness in hypertension patients and (2) to estimate the diagnostic and predictive value of TC, TG, LDL-C, HDL-C, non-HDL-C, AIP, AI and TC/HDL-C indices.…”

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confidence: 99%

Relationship between blood lipid and arterial stiffness in hypertension

Liu

2019

CIM

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Purpose: To explore the relationship between blood lipids and pulse wave velocity (PWV). Methods: We retrospectively selected subjects who had undergone treatment in an outpatient or inpatient clinic. The subjects were sub-grouped into four groups: Group A (no history of hypertension and dyslipidemia), Group B (a history of dyslipidemia but not hypertension), Group C (a history of hypertension but not dyslipidemia) and Group D (a history of both hypertension and dyslipidemia). We determined brachial-ankle pulse wave velocity (baPWV), atherogenic index of plasma (AIP), non-high-density lipoprotein (non-HDL-C), total cholesterol/high density lipoprotein (TC/HDL-C) and atherogenic indices (AI) for hypertension and non-hypertension and dyslipidemia and non-dyslipidemia patients. Results: A total of 380 subjects were included. Uric acid, systolic pressure, diastolic pressure, pulse pressure and mean arterial pressure were significantly different among the groups. The prevalence of coronary arterial disease and diabetes mellitus, age, body mass index, heart rate, blood glucose, creatinine, urea, smoking history and alcohol consumption did not differ among groups. The baPWV was significantly different between both hypertension/nonhypertension and dyslipidemia/non-dyslipidemia patients. In hypertension patients (in Group C and D), partial correlation analysis showed that ΔbaPWV correlated with TC, HDL-C, AI, AIP and TC/HDL-C but not LDL-C, triglyceride (TG) or non-HDL-C. Conclusion: Hypertension and/or dyslipidemia may be risk factors for arterial stiffness. In hypertension patients, TC, HDL-C, AIP, AI and TC/HDL-C might correlate to arterial stiffness and pathological increases in these levels may indicate risk factors for arterial stiffness.

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Non-HDL-C is a Better Predictor for the Severity of Coronary Atherosclerosis Compared with LDL-C

Cited by 48 publications

References 17 publications

Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Apolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol

Relationship between blood lipid and arterial stiffness in hypertension

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