Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Ma, Hui; Hao, Lin; Hu, Yu; Li, Xiaoming; He, Wenzhuan; Jin, Xuejuan; Gao, Xin; Zhao, Na; Pan, Boshen; Gao, Xin

doi:10.1186/s12944-017-0451-4

Cited by 14 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our observation shows that non-HDL-c, TG, and the TC/ HDL-c ratio were associated with arterial stiffness is consistent with most previous studies, although different indices were adopted [16][17][18][19][20]. Non-HDL-c was calculated as TC minus HDL-c and thus included all atherogenic lipoproteins (VLDL, intermediate-density lipoprotein cholesterol (IDL-c), LDL-c, and lipoprotein(a)) [5].…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population

Wen

Huang

et al. 2019

Hypertens Res

View full text Add to dashboard Cite

Several lipid parameters are closely associated with residual cardiovascular risk. We aimed to confirm that in a range of lowdensity lipoprotein cholesterol (LDL-c) levels (from <70 mg/dl to ≥160 mg/dl), other lipid parameters, such as triglyceride (TG) level, non-high-density lipoprotein cholesterol (non-HDL-c) level, and the total cholesterol (TC)/HDL-c ratio, are still related to arterial stiffness, which is a recognized marker of atherosclerosis. In this cross-sectional study, we measured brachial-ankle pulse wave velocity (baPWV), as well as clinical and biochemical indices in 16,733 Chinese adult volunteers who underwent health checkups from January 2014 to January 2015. Arterial stiffness was defined as the upper quartile of baPWV. We applied multivariable logistic regression models to examine the associations between lipid parameters and arterial stiffness. Both men and women with high baPWV were more likely to have an atherogenic lipid phenotype. Among participants with LDL-c <70 mg/dl, participants with non-HDL-c ≥100 mg/dl had a multivariable adjusted OR for arterial stiffness of 1.66 (1.11-2.50) compared to those with non-HDL-c <100 mg/dl; participants with TG ≥150 mg/dl had an OR of 2.44 (1.61-3.71) compared to those with TG <150 mg/dl; and participants with a TC/HDL-c ratio ≥4 had an OR of 1.74 (1.15-2.65) compared to those with a TC/HDL-c ratio <4. Similar results were observed at other LDL-c levels. We found that non-HDL-c, TG, and the TC/HDL-c ratio were consistently associated with arterial stiffness in a range of LDL-c levels, even when LDL-c was below 70 mg/dl. These lipid measures are related to residual cardiovascular risk, possibly due to their detrimental effects on vascular structure. Keywords Low-density lipoprotein cholesterol • Non-high-density lipoprotein cholesterol • Triglycerides • Total cholesterol/ HDL-c ratio • Brachial-ankle pulse wave velocity • Arterial stiffness • Cardiovascular disease

show abstract

Section: Discussionsupporting

confidence: 86%

“…Several studies have shown a strong association between lipid levels (low HDL-c, high TGs, and non-HDL-c, high TG/HDL-C and TC/HDL-C ratio, etc.) and baPWV [16][17][18][19][20]. However, some of those studies had a small sample size [16][17][18] or included only special populations [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population

Wen

Huang

et al. 2019

Hypertens Res

View full text Add to dashboard Cite

show abstract

“…To compare our results with previous studies, we searched PubMed to identify population‐based studies that reported the prevalence of CA detected by ultrasound in China, and summarized findings are shown in Table 4. Of these previous studies,16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 only the CKB (China Kadoorie Biobank) study included a large sample of participants (N=24 822) from multiple geographic regions in China16; all other studies were geographically local. The CKB study reported that the overall prevalence of carotid plaque was 31%, which was much higher than the prevalence of 13.9% in the present study; however, the CKB study included participants with stroke (5.4%) or coronary heart disease (7.5%).…”

Section: Discussionmentioning

confidence: 99%

“…The CKB study reported that the overall prevalence of carotid plaque was 31%, which was much higher than the prevalence of 13.9% in the present study; however, the CKB study included participants with stroke (5.4%) or coronary heart disease (7.5%). Of the studies that excluded people with prior CVDs, the prevalence of carotid plaque was 9.7% in villages in Xinjiang,17 18.8% in Shanghai city,18 16.8% to 30.6% in Nanjing city,19 and 41.5% in a low‐income rural community in Tianjin 20. The reported overall prevalence of CA or increased IMT was from 11.2% in a rural community in Shandong21 to as high as 40.3% in Shenyang city 22.…”

Section: Discussionmentioning

confidence: 99%

Carotid Atherosclerosis Detected by Ultrasonography: A National Cross‐Sectional Study

Wang¹,

Li²,

Song

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundCarotid atherosclerosis (CA) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of CA detected by carotid ultrasonography and related risk factors based on a national survey in China.Methods and ResultsA total of 107 095 residents aged ≥40 years from the China National Stroke Prevention Project underwent carotid ultrasound examination. Participants with carotid endarterectomy or carotid stenting and those with stroke or coronary heart disease were excluded. Data from 84 880 participants were included in the analysis. CA was defined as increased intima–media thickness (IMT) ≥1 mm or presence of plaques. Of the 84 880 participants, 46.4% were men, and the mean age was 60.7±10.3 years. The standardized prevalence of CA was 36.2% overall, increased with age, and was higher in men than in women. Prevalence of CA was higher among participants living in rural areas than in urban areas. Approximately 26.5% of participants had increased IMT, and 13.9% presented plaques. There was an age‐related increase in participants with increased IMT, plaque presence, and stenosis. In multiple logistic regression analysis, older age, male sex, residence in rural areas, smoking, alcohol consumption, physical inactivity, obesity, hypertension, diabetes mellitus, and dyslipidemia were associated with CA.Conclusions CA was highly prevalent in a middle‐aged and older Chinese population. This result shows the potential clinical importance of focusing on primary prevention of atherosclerosis progression.

show abstract

“…In the current study, we found that circulating full-length ANGPTL8 concentrations positively correlated with serum non-HDL-C levels. Non-HDL-C, which represents the total cholesterol content of apolipoprotein B containing lipoproteins [ 38 ], includes the TG-rich lipoproteins (very LDL, intermediate-density lipoproteins, and remnants) [ 39 ]. Non-HDL-C is strong predictive factor that directly reflects the total number of atherogenic lipoprotein particles [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

et al. 2018

View full text Add to dashboard Cite

BackgroundAngiopoietin-like protein 8 (ANGPTL8) is a novel hormone involved in the regulation of lipid metabolism and glucose homeostasis. There are inconsistent results regarding the association between ANGPTL8 and lipids in humans. We aimed to investigate the associations between ANGPTL8 and lipids in people without diabetes.MethodsThis was a cross-sectional study of 107 patients with dyslipidemia and 141 patients without. Dyslipidemia diagnosis was based on Chinese guidelines for the prevention and treatment of dyslipidemia in adults. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol (HDL-C) were examined. Non-HDL-C was calculated by subtracting HDL-C from TC. Circulating full-length ANGPTL8 concentrations were measured using enzyme-linked immunosorbent assay. Associations between log-transformed circulating full-length ANGPTL8 and serum lipids were examined using multivariate linear regression analysis.ResultsCirculating ANGPTL8 concentrations were significantly elevated in patients with dyslipidemia compared with patients without dyslipidemia. Circulating full-length ANGPTL8 concentrations were positively associated with non-HDL-C, TG and TC levels after adjusting for age, gender, body mass index, high-sensitivity C-reactive protein, alanine aminotransferase, and creatinine.ConclusionIn people without diabetes, circulating full-length ANGPTL8 concentrations in patients with dyslipidemia were significantly elevated compared with non-dyslipidemia, and ANGPTL8 was positively associated with serum non-HDL-C levels.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0802-9) contains supplementary material, which is available to authorized users.

show abstract

Relationship between non–high-density lipoprotein cholesterol and carotid atherosclerosis in normotensive and euglycemic Chinese middle-aged and elderly adults

Cited by 14 publications

References 33 publications

Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population

Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population

Carotid Atherosclerosis Detected by Ultrasonography: A National Cross‐Sectional Study

Association between circulating full-length angiopoietin-like protein 8 and non-high-density lipoprotein cholesterol levels in Chinese non-diabetic individuals: a cross-sectional study

Contact Info

Product

Resources

About