Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C

Salihoğlu, Yavuz; Elri, Tarik; Gülle, Kanat; Çan, Murat; Aras, Mustafa; Özaçmak, Hale Sayan; Cabuk, Mehmet

doi:10.1080/0886022x.2016.1227919

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…Another report also noted that a single i.p. dose of 7.5 mg/kg CDDP significantly elevated renal toxicity biomarkers level and caused remarkable damage to glomerular and tubular structures [35] . Additionally, Dirican et al in 2016 noted that serum cystatin-c and lipocalin-2 levels were markedly elevated in rats treated with a single i.p.…”

Section: Discussionmentioning

confidence: 96%

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Ewees

Abdel-Bakky

Bayoumi

et al. 2021

Journal of Advanced Research

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Section: Discussionmentioning

confidence: 96%

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Ewees

Abdel-Bakky

Bayoumi

et al. 2021

Journal of Advanced Research

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“…Recent studies have shown that 99m Tc-DMSA static renal scintigraphy is a sensitive and reliable test for the early detection of the kidney damage. 25,26…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the protective effect of paricalcitol and vitamin D₃at doxorubicin nephrotoxicity in rats with^99mTechnetium-dimercaptosuccinic acid renal scintigraphy and biochemical methods

2020

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Aim: The present study aimed to examine the effect of paricalcitol (PRC) and vitamin D3 (vit D3) on doxorubicin (DOX)-induced nephrotoxicity in rats. Materials and Methods: Forty-two Wistar rats were randomly categorized into six groups: control; 2) PRC(0.5 µg/kg) and 3) vit D3(5.000 IU/kg) administered for 14 days; 4) DOX, 18 mg/kg administered on the 12th, 13th and 14th days of the study; 5) PRC (0.5 µg/kg, +DOX(18 mg/kg); vit D3(5.000 IU)+DOX(18 mg/kg). On the 15th day of the experiment, 99mTc-DMSA uptake level and biochemical parameter in serum and tissue were assay. Results: Activities of 99mTechnetium-Dimercaptosuccinic Acid (99mTc-DMSA) were lower in groups receiving DOX and/or PRC+DOX, vit D3+DOX than in control groups. The 99mTc-DMSA level in the group PRC+DOX and vit D3+DOX were importantly higher than DOX group. DOX caused an important increase in blood urea nitrogen (BUN), creatinine, Tumor Necrosis Factor-α(TNF- α), interleukin-6(IL-6) and nitric oxide(NO) levels compared to control groups. However, PRC and vit D3 pretreatments lowered them. Uptake of 99mTc-DMSA level was higher in groups PRC+DOX than in vit D3+DOX group. Administration of PRC and vit D3 alone did not change alterations all of parameters. Conclusion: The results indicated that PRC administration protects kidney in DOX-induced nephrotoxic rats. In addition, PRC has a stronger nephroprotective effect than vit D3.

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“…There was no correlation among the level of Cystatin C after the cisplatin infusion and serum creatinine level following the third course and modification of diet in renal disease and creatinine clearance-Cockcroft-Gault formulations 39 . Previous studies have also used serum Cystatin C levels to evaluate that agma-tine has a protective effect against cisplatininduced nephrotoxicity 40 .…”

Section: Renalmentioning

confidence: 99%

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

Viniegra¹,

Shiguetomi²,

Glogauer³

2018

CMRJ

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Cystatin C is a low-molecular-weight biomarker that meets the conditions necessary to be a marker of the glomerular filtration rate. This endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily plays a key role in health and disease. Human cystatin C is encoded by the CST3 gene, ubiquitously expressed at moderate levels throughout the body, given it is produced in all nucleated cells in a constant amount. It is present in all human body fluids, and may be determined in the serum, plasma, capillary blood and urine. In this review, we present and discuss most of the available data from the literature for the use of cystatin C in clinical practice. In addition to a kidney function marker, studies suggest cystatin C could be used as a marker for cardiovascular risk assessment, in predicting and detecting preeclampsia, in patients with malignant neoformations, etc. Local cystatin C deficiency has also been demonstrated in atherosclerosis, aneurismal lesions, among others, suggesting a protective role of cystatin C. Far beyond its humble beginning, it promises uses from prognosis to treatments for everything from prostate cancer to periodontal disease. Cystatin C has begun its journey into a multitude of disciplines; we can only begin to imagine the many more purposes yet to find going forward.

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Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C

Cited by 8 publications

References 25 publications

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Evaluation of the protective effect of paricalcitol and vitamin D₃at doxorubicin nephrotoxicity in rats with^99mTechnetium-dimercaptosuccinic acid renal scintigraphy and biochemical methods

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

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Evaluation of the protective effect of agmatine against cisplatin nephrotoxicity with 99mTc-DMSA renal scintigraphy and cystatin-C

Cited by 8 publications

References 25 publications

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Evaluation of the protective effect of paricalcitol and vitamin D3at doxorubicin nephrotoxicity in rats with99mTechnetium-dimercaptosuccinic acid renal scintigraphy and biochemical methods

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

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Evaluation of the protective effect of paricalcitol and vitamin D₃at doxorubicin nephrotoxicity in rats with^99mTechnetium-dimercaptosuccinic acid renal scintigraphy and biochemical methods