Treatment Access and Survival Amongst British Asians with Pancreatic Cancer

Isherwood, John; Bilku, D.; Metcalfe, Matthew S.; Dennison, Ashley R.; Garcea, Giuseppe

doi:10.1007/s00268-016-3707-7

Cited by 3 publications

(2 citation statements)

References 44 publications

(45 reference statements)

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“…Isherwood et al reported that Asians/Asian British had higher overall survival and survival for subjects who received palliative therapy (6.1 months and 5.1 months, respectively) compared to White British (4.6 months and 3.7 months, respectively). Median survival in subjects who underwent surgical resection was, however, similar (25.0 months in Asians/Asian British vs. 20.7 months in White British) [39].…”

Section: Discussionmentioning

confidence: 86%

Temporal trends of incidence and mortality in Asian-Americans with pancreatic adenocarcinoma: an epidemiological study

Gad

Găman

Saad

et al. 2020

aog

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Background Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with an estimated 45,750 deaths in 2019. Mortality outcomes seem to differ based on the ethnicity of the patients, with most studies focusing on the mortality and survival of Caucasians and African Americans. Little attention has been given, however, to Asian-American patients diagnosed with pancreatic adenocarcinoma (PAC). In this study, we aimed to investigate mortality rates in Asian-American patients with PAC. Methods The SEER 13 registries (Surveillance, Epidemiology, and End-Results) of the National Cancer Institute were used to study PAC cases during 1992-2015. The incidence and incidencebased mortality rates per 100,000 person-years, and the annual percentage changes were calculated using SEER*stat software and Joinpoint regression software. Results A total of 5814 PAC cases in Asian-American patients were identified. Most patients were older than 60 years (77.6%) and had metastatic disease (55.8%). The overall incidence of PAC among Asian-Americans was 5.740 per 100,000 person-years (95% confidence interval [CI] 5.592-5.891]. Incidence rates were highest among males and patients older than 60 years. PAC incidence rates among Asian-Americans increased by 1.503% (95%CI 1.051-1.956; P<0.001) per year over the study period. PAC incidence rates increased over the study period for all sex, age, and stage subgroups. PAC incidence-based mortality among Asian-Americans increased by 4.535% (95%CI 3.538-5.541; P<0.001) per year over the study period. Conclusion The incidence of PAC in Asian-Americans, as well as incidence-based mortality rates, are on the rise, irrespective of age, sex or stage subgroup.

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Section: Discussionmentioning

confidence: 86%

Temporal trends of incidence and mortality in Asian-Americans with pancreatic adenocarcinoma: an epidemiological study

Gad

Găman

Saad

et al. 2020

aog

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“…20 A similar cohort result had shown that the overall survival and the survival of patients having palliative treatment were significantly greater in Asian/Asian British compared with White British. 21 Given the highly lethal nature of PC, there is a great urgent need to elucidate the underling mechanisms for the mesenchymal huge difference between the Asian patients and other ethnic populations.…”

Section: Discussionmentioning

confidence: 99%

Identification of 2 Chinese Primary Pancreatic Ductal Adenocarcinoma Cancer Cell Lines and Their Phenotypes

Wang

Chen

et al. 2021

Pancreas

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Objectives: Pancreatic cancer (PC) is one of the most lethal cancers. Currently, the most commonly used PC cell lines were all derived from White individuals, and few models can be used to study in Asian populations. In China, the incidence of PC is increasing every year, highlighting the need to develop new Chinese PC cell lines for cancer research.Methods: A total of 203 patients diagnosed with PC, enrolled from January 2012 to December 2017 in our hospital (Department of Hepatobiliary and Pancreatic Surgery), had received surgery. Primary PC patient tumor samples were harvested sterilely from surgery, minced, and digested in collagenase. Cells were cultured in plates precoated with L-polylysine.Results: Two primary PC cell lines, Si-Liang 187 and Si-Liang 188, were established, both of which grew as adherent monolayers and demonstrated distinguished phenotypes. Si-Liang 187 shows the typical mesenchymal pattern, whereas Si-Liang 188 shows epithelial phenotype. Moreover, they carry different genetic backgrounds according to whole exome sequencing.Conclusions: Two new Chinese PC cell lines were established, both of which were characterized and confirmed with high tumorigenicity. They may serve as useful tools for pathogenesis research when evaluating new treatment strategies in Asian patients.

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Hepatopancreaticobiliary cancer outcomes are associated with county-level duration of poverty

Lima

Woldesenbet

Hamad

et al. 2023

Surgery

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Treatment Access and Survival Amongst British Asians with Pancreatic Cancer

Cited by 3 publications

References 44 publications

Temporal trends of incidence and mortality in Asian-Americans with pancreatic adenocarcinoma: an epidemiological study

Temporal trends of incidence and mortality in Asian-Americans with pancreatic adenocarcinoma: an epidemiological study

Identification of 2 Chinese Primary Pancreatic Ductal Adenocarcinoma Cancer Cell Lines and Their Phenotypes

Hepatopancreaticobiliary cancer outcomes are associated with county-level duration of poverty

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