Role of regulatory B cells in immune tolerance to allergens and beyond

Veen, Willem van de; Stanić, Barbara; Wirz, Oliver F.; Jansen, Kirstin; Głobińska, Anna

doi:10.1016/j.jaci.2016.07.006

Cited by 207 publications

(181 citation statements)

References 85 publications

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“…Adoptive transfer of these cells strongly suppresses allergic airway inflammation in an ovalbumin-sensitized mice model [12].…”

Section: Cd71mentioning

confidence: 99%

“…+ phenotype and have been studied in the context of allergen tolerance induction [12]. Functionally, Br1 and B10 cells are IL-10-producing Breg cells, and both nomenclatures are used in the literature.…”

Section: Cd71mentioning

confidence: 99%

“…The incidence of allergic disorders is lower in individuals infected by helminths than among noninfected individuals [17]. Moreover, Breg cell production might be induced by bacterial or parasitic infections [12].…”

Section: Cd71mentioning

confidence: 99%

“…hi B10 subset, and their effect is mostly mediated through secretion of IL-10 [12]. Additionally, other types of Bregs can be induced in helminth infection.…”

Section: Cd71mentioning

confidence: 99%

“…Thus, helminth infections can contribute to an immunoregulatory environment and promote both dampening of T H 1-, T H 17,-and T H 2-skewed diseases [12]. Infection with S mansoni proved to be protective in an experimental model of systemic anaphylaxis [18].…”

Section: Cd71mentioning

confidence: 99%

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Regulatory B Cells and Allergy: Uncovering the Link

Mota¹,

Martins²,

Borrego³

2017

J Investig Allergol Clin Immunol

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Regulatory B (Breg) cells are recognized as immunosuppressive cells. During the last few years, several subsets of Breg cells with different phenotypes and suppressive mechanisms have been described in the literature. We review the role of Breg cells in allergy based on an extensive literature search in PubMed. We describe the types and mechanisms of action of B cells and their role in the pathogenesis of several allergic diseases (allergic asthma, allergic rhinitis, food allergy, contact hypersensitivity, and anaphylaxis). ResumenLos linfocitos reguladores del tipo B (B reg.) juegan un papel importante en el funcionamiento del sistema inmunitario. Durante los últimos años, se han descrito varios subgrupos de linfocitos B reg., con diferentes fenotipos y mecanismos supresores. Nuestro objetivo es recopilar la información existente sobre el papel de los linfocitos B reg. en Alergología, en base a una profunda investigación bibliográfica en PubMed. Describimos los tipos y mecanismos de acción de los linfocitos B y su función en la patogénesis de varias enfermedades alérgicas (asma alérgica, rinitis alérgica, alergia alimentaria, eccema de contacto y anafilaxia). Palabras clave: Linfocitos B reguladores. Alergia. Enfermedad alérgica. Tolerancia a alérgenos. B10. Br1. Asma. Alergia alimentaria. Alergia al veneno de himenópteros. Embarazo.

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“…Adoptive transfer of these cells strongly suppresses allergic airway inflammation in an ovalbumin-sensitized mice model [12].…”

Section: Cd71mentioning

confidence: 99%

Section: Cd71mentioning

confidence: 99%

Section: Cd71mentioning

confidence: 99%

“…hi B10 subset, and their effect is mostly mediated through secretion of IL-10 [12]. Additionally, other types of Bregs can be induced in helminth infection.…”

Section: Cd71mentioning

confidence: 99%

Section: Cd71mentioning

confidence: 99%

See 3 more Smart Citations

Regulatory B Cells and Allergy: Uncovering the Link

Mota¹,

Martins²,

Borrego³

2017

J Investig Allergol Clin Immunol

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Single‐Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression

Yang

et al. 2021

Advanced Science

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Although degeneration of the nucleus pulposus (NP) is a major contributor to intervertebral disc degeneration (IVDD) and low back pain, the underlying molecular complexity and cellular heterogeneity remain poorly understood. Here, a comprehensive single-cell resolution transcript landscape of human NP is reported. Six novel human NP cells (NPCs) populations are identified by their distinct molecular signatures. The potential functional differences among NPC subpopulations are analyzed. Predictive transcripts, transcriptional factors, and signal pathways with respect to degeneration grades are explored. It is reported that fibroNPCs is the subpopulation for end-stage degeneration. CD90+NPCs are observed to be progenitor cells in degenerative NP tissues. NP-infiltrating immune cells comprise a previously unrecognized diversity of cell types, including granulocytic myeloid-derived suppressor cells (G-MDSCs). Integrin 𝜶M (CD11b) and oxidized low density lipoprotein receptor 1 (OLR1) as surface markers of NP-derived G-MDSCs are uncovered. The G-MDSCs are found to be enriched in mildly degenerated (grade II and III) NP tissues compared to severely degenerated (grade IV and V) NP tissues. Their immunosuppressive function and alleviation effects on NPCs' matrix degradation are revealed in vitro. Collectively, this study reveals the NPC-type complexity and phenotypic characteristics in NP, thereby providing new insights and clues for IVDD treatment.

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