Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis

Shao, Jianbo; Luo, Xiang‐Qian; Wu, Yusheng; Li, Mao-Gang; Hong, Jingyi; Mo, Li‐Hua; Liu, Zhigang; Li, Hua-Bin; Liu, Dabo; Yang, Ping‐Chang

doi:10.1002/alr.22171

Cited by 21 publications

(14 citation statements)

References 27 publications

(30 reference statements)

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“…Results are expressed as mean ± SEM (n 3). the expression of HDAC11 in B cells in a dose-dependent manner (Shao et al, 2018). Our study also indicated that TNF-α can upregulate the protein and mRNA expressions of HDAC11 in HUVECs, while HT-AC decreased HDAC11 protein and mRNA expressions in TNF-α-stimulated HUVECs.…”

Section: Discussionsupporting

confidence: 65%

Hydroxytyrosol Acetate Inhibits Vascular Endothelial Cell Pyroptosis via the HDAC11 Signaling Pathway in Atherosclerosis

Yao

Zhang

et al. 2021

Front. Pharmacol.

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Hydroxytyrosol acetate (HT-AC), a natural polyphenolic compound in olive oil, exerts an anti-inflammatory effect in cardiovascular diseases (CVDs). Pyroptosis is a newly discovered form of programmed inflammatory cell death and is suggested to be involved in the atherosclerosis (AS) process. However, the effect of HT-AC on vascular endothelial cell pyroptosis remains unknown. Thus, we aimed to investigate the effect of HT-AC on vascular endothelial cell pyroptosis in AS and related signaling pathways. In vivo studies showed that HT-AC alleviated the formation of atherosclerotic lesions and inhibited pyroptosis in the aortic intima of ApoE−/− mice fed a high-fat diet (HFD) for 12 weeks. In vitro, we found that HT-AC treatment of human umbilical vein endothelial cells (HUVECs) alleviated tumor necrosis factor-alpha (TNF-α)-induced pyroptosis by decreasing the number of PI positive cells, decreasing the enhanced protein expressions of activated caspase-1 and gasdermin D (GSDMD), as well as by decreasing the release of pro-inflammatory interleukin (IL)-1β and IL-6. Besides, HT-AC down-regulated HDAC11 expression in the aortic intima of HFD-fed ApoE−/− mice and TNF-α-stimulated HUVECs. To determine the underlying mechanism of action, molecular docking and drug affinity responsive target stability (DARTS) were utilized to identify whether HDAC11 protein is a target of HT-AC. The molecular docking result showed good compatibility between HT-AC and HDAC11. DARTS study's result showed that HDAC11 protein may be a target of HT-AC. Further study demonstrated that knockdown of HDAC11 augmented the inhibition of HT-AC on pyroptosis in TNF-α-stimulated HUVECs. These findings indicate that HT-AC might prevent vascular endothelial pyroptosis through down-regulation of HDAC11 related signaling pathway in AS.

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Section: Discussionsupporting

confidence: 65%

Hydroxytyrosol Acetate Inhibits Vascular Endothelial Cell Pyroptosis via the HDAC11 Signaling Pathway in Atherosclerosis

Yao

Zhang

et al. 2021

Front. Pharmacol.

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“…Targeting HAT Tip60 inhibits intestinal allergies in a mouse model (10). The expression of HdAc1, HdAc5, HdAc6 and HdAc8 increases in asthmatic mice (11); HdAc11 (12) and HdAc1 (13) expression levels are increased in patients with AR, and HdAc1 also participates in the pathogenesis of childhood asthma (14).…”

Section: Introductionmentioning

confidence: 99%

HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice

et al. 2020

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Our previous study demonstrated that intranasal administration of histone deacetylase inhibitor sodium butyrate (NaB) exhibits therapeutic effects on a mouse model of allergic rhinitis (AR). However, whether NaB is effective on AR when administered orally and prophylactically, as well as its potential effects on gene expression, remained unknown. The present study aimed to investigate the preventive effect of NaB on AR when added to the diet of newly weaned mice and to evaluate the changes in long non-coding (lnc)RNA and mRNA expression profiles in the nasal mucosa. Mice were randomly divided into three groups as follows: i) control (c) group, (no treatment); ii) AR group [treated with ovalbumin (OVA)]; and iii) NaB + AR group (treated with OVA and NaB). The NaB + AR group was administered NaB in their feed (30 g/kg chow), whereas the other two groups were fed normal feed between 3 and 6 weeks of age. At 7 weeks of age, OVA administration was initiated to induce AR in the AR and NaB + AR groups. Following model establishment, behavioral assessments, western blotting and gene expression analysis were performed. NaB exhibited a preventive effect in the murine AR model, diminished the increases in histone deacetylase 1 (HdAc1) and HdAc8 expression and increased OVA-induced acetylation of histone H3 at lysine 9. In addition, NaB increased the AR-associated low expression of interleukin 2 (IL-2), interferon γ and IL-17 and decreased the expression of IL-4, IL-5 and transforming growth factor β1. Gene Ontology and pathway analyses revealed the top 10 pathways among the groups. Octamer-binding transcription factor 1, ecotropic viral integration site 1 and paired box 4 were predicted to be target genes of lncRNA (NONMMUT057309). Thus, NaB may exhibit a preventive effect on AR. Additionally, the lncRNA and mRNA expression profiles in the nasal mucosa of mice with AR differed significantly following NaB treatment. These results may provide insights into the pathogenesis of AR and suggest new treatment targets.

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“…By binding to HDAC1 and the Il10 gene, NFATc1 suppressed B‐cell IL‐10 expression [95]. Shao et al reported higher levels of HDAC11 and lower levels of IL‐10 expression in B cells from allergic rhinitis patients when compared to healthy controls [96]. Introduction of HDAC11 shRNA significantly attenuated murine allergic rhinitis, and HDAC11‐mediated suppression of IL‐10 expression was elicited through HDAC‐mediated deacetylation of c‐Maf, which reduced c‐Maf binding to the il10 locus.…”

Section: Introductionmentioning

confidence: 99%

Regulatory B cells in transplantation: roadmaps to clinic

et al. 2020

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Over the last two decades, an additional and important role for B cells has been established in immune regulation. Preclinical studies demonstrate that regulatory B cells (Breg) can prolong allograft survival in animal models and induce regulatory T cells. Operationally tolerant human kidney transplant recipients demonstrate B-cell-associated gene signatures of immune tolerance, and novel therapeutic agents can induce Bregs in phase I clinical trials in transplantation. Our rapidly expanding appreciation of this novel B-cell subtype has made the road to clinical application a reality. Here, we outline several translational pathways by which Bregs could soon be introduced to the transplant clinic.

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Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis

Abstract: TNF can suppress the expression of IL-10 in B cells via enhancing the expression of HDAC11. Inhibition of HDAC11 restores the IL-10 expression in B cells of AR subjects. HDAC11 may be a novel target for the treatment of AR.

Cited by 21 publications

References 27 publications

Hydroxytyrosol Acetate Inhibits Vascular Endothelial Cell Pyroptosis via the HDAC11 Signaling Pathway in Atherosclerosis

Hydroxytyrosol Acetate Inhibits Vascular Endothelial Cell Pyroptosis via the HDAC11 Signaling Pathway in Atherosclerosis

HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice

Regulatory B cells in transplantation: roadmaps to clinic

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