Dysfunctional HDL in acute stroke

Ortiz-Muñoz, Guadalupe; Couret, David; Lapergue, Bertrand; Bruckert, Éric; Meseguer, Elena; Amarenco, Pierre; Meilhac, Olivier

doi:10.1016/j.atherosclerosis.2016.08.035

Cited by 35 publications

(31 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3a). This result may explain why the exposure of HDL-c particles to oxidation in PE women affects PON-I activity and generates a “dysfunctional HDL”, as noted previously [8, 9]. Another cause of the decrease in PON-I activity in women with PE is the liver damage which are associated with the elevation of TGO and TGP enzymes and may affect PON-I synthesis.…”

Section: Discussionmentioning

confidence: 55%

“…PON-I is an HDL-associated esterase that has been shown to protect against lipid peroxide formation in LDL-c and HDL-c [7]. Several authors suggest that HDL-c particles are susceptible to lipid and protein oxidation (the carbonylation of proteins, the formation of dityrosines and reduction of nitroblue tetrazolium), which alters their structure and creates “dysfunctional HDL” particles [8, 9]. HDL-c is a protective agent for vascular function because it contains Apo-AI.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative profiles of LDL and HDL isolated from women with preeclampsia

et al. 2017

View full text Add to dashboard Cite

BackgroundOxidative stress causes biochemical changes in lipids and proteins; these changes can induce damage to the vascular endothelium and create maternal complications that are characteristic of preeclampsia. In this study, we evaluated the oxidative profile of lipoproteins isolated from women with preeclampsia. MethodsThirty women diagnosed with preeclampsia and thirty women without preeclampsia were included in the study. Lipid-damage biomarkers, including conjugated dienes, lipohydroperoxides and malondialdehyde, were measured. The reduction of nitroblue tetrazolium, the formation of dityrosines, and the carbonylation of proteins were assessed as indicators of protein damage. The protective activity of HDL-c was evaluated by the paraoxonase-I activity present on the HDL-c particles. Serum lipid profiles were also quantified in both groups. Data were analysed using Student’s t test and the Pearson correlation coefficient.ResultsOur results demonstrated in PE women evident oxidative changes in the lipids and proteins in HDL-c and LDL-c particles and the activity of the antioxidant enzyme PON-I decreased 59.9%. HDL-c exhibited self-defence, as demonstrated by the negative correlation between paraoxonase-I activity and the formation of lipohydroperoxides in HDL-c (r = −0.3755, p < 0.005).ConclusionsLDL-c and HDL-c isolated from women with preeclampsia show oxidative damage to lipids and proteins. We propose an oxidative profile based on the oxidation levels indicated by each of the markers used. We also found that paraoxonase-I is inactivated in the presence of lipohydroperoxides. Antioxidant support might be helpful to reduce oxidative stress in patients with preeclampsia. Further investigations are necessary to define the association between antioxidant activities and preeclampsia.

show abstract

Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Oxidative profiles of LDL and HDL isolated from women with preeclampsia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Our results showed that high acute-phase HDL had association with 30-day mortality in HS (Table 3), and with stroke severity in IS (Table 5), and low TC/HDL ratio had association with both 30-day and 1-year mortality in IS. Although acute stroke relative to controls may have an increased proportion of dysfunctional HDL with abundant myeloperoxidase and α1-antitrypsin, resulting in an inappropriate protection of endothelial cells under stressful conditions (48), the association between HDL and stroke outcome is still inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Lipid Paradox in Statin-Naïve Acute Ischemic Stroke But Not Hemorrhagic Stroke

et al. 2018

View full text Add to dashboard Cite

Background: Low lipid level is associated with better cardiovascular outcome. However, lipid paradox indicating low lipid level having worse outcomes could be seen under acute injury in some diseases. The present study was designed to clarify the prognostic significance of acute-phase lipid levels within 1 day after admission for stroke on mortality in first-ever statin-naïve acute ischemic stroke (IS) and hemorrhagic stroke (HS).Methods: This observational study was conducted using the data collected from Stroke Registry In Chang-Gung Healthcare System (SRICHS) between 2009 and 2012. Patients with recurrent stroke, onset of symptoms >1 day, and history of the use of lipid-lowering agents prior to index stroke were excluded. Stroke was classified into IS and hypertension-related HS. The primary outcomes were 30-day and 1-year mortality identified by linkage to national death registry for date and cause of death. Receiver operating characteristic (ROC) curve analysis and multivariate Cox proportional hazard models were used to examine the association of lipid profiles on admission with mortality.Results: Among the 18,268 admitted stroke patients, 3,746 IS and 465 HS patients were eligible for analysis. In IS, total cholesterol (TC) <163.5 mg/dL, triglyceride (TG) <94.5 mg/dL, low-density lipoprotein (LDL) <100 mg/dL, non-high-density lipoprotein cholesterol (non-HDL-C) <130.5 mg/dL, and TC/HDL ratio <4.06 had significantly higher risk for 30-day/1-year mortality with hazard ratio (HR) of 2.05/1.37, 1.65/1.31, 1.68/1.38, 1.80/1.41, and 1.58/1.38, respectively, compared with high TC, TG, LDL, non-HDL-C, and TC/HDL ratio (p < 0.01 in all cases). In HS, lipid profiles were not associated with mortality, except HDL for 30-day mortality (p = 0.025) and high uric acid (UA) concentrations for 30-day and 1-year mortality (p = 0.002 and 0.012, respectively). High fasting glucose and high National Institute of Health Stroke Scale (NIHSS) score at admission were associated with higher 30-day and 1-year mortality in both IS and HS and low blood pressure only in IS (p < 0.05). Synergic effects on mortality were found when low lipids were incorporated with high fasting glucose, low blood pressure, and high NIHSS score in IS (p < 0.05).Conclusions: Lipid paradox showing low acute-phase lipid levels with high mortality could be seen in statin-naïve acute IS but not in HS. The mortality in IS was increased when low lipids were incorporated with high fasting glucose, low blood pressure, and high NIHSS score.

show abstract

“…Data were from 3 independent microarrays 19 Meanwhile, it was suggested that the expression of MMP3 was upregulated after the breaking of barrier function of endothelial cells. 20 Additionally, as a membrane-anchored proteinase, MMP-23 contains the unique cysteine array and an immunoglobulin-like domain, 21 which may be related to extracellular matrix reorganization and microvascular barrier function maintenance. 22 Furthermore, recently, data support that FOXP3 is involved in endothelial dysfunction through inflammatory process.…”

Section: Stc Analysis Of Degsmentioning

confidence: 99%