Dataset of liver proteins of eu- and hypothyroid rats affected in abundance by any of three factors: in vivo exposure to hexabromocyclododecane (HBCD), thyroid status, gender differences

Abstract

Male Wistar rats with different thyroid status (eu-, hypothyroid) were exposed to 0, 3 or 30 mg/kg body weight of the flame retardant HBCD for 7 days and obtained data compared with a previous study in females, “Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats” (Miller et al., 2016) [1]. Specifically, proteomic investigation of liver protein patterns obtained by 2D-DIGE was performed and differences between animals groups recorded, based on the factors exposure, thyroid status and gender. All proteins with significantly changed abundance in any of these comparisons were identified by mass spectrometry. General, hormone and proteomic data of both the present and the previous studies are discussed in Miller et al. (2016) [1] and in "Gender specific differences in the liver proteome of rats exposed to hexabromocyclododecane (HBCD)" Miller et al. (2016) [2].

Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes

“…Our results showed two genes at the main intersection of the diagram, glutathione S-transferase alpha-3 ( Gsta3 ) and ELMO domain containing 2 ( Elmod2 ). Gsta3 is a gene regulated by the thyroid hormone in the liver [ 36 ] that catalyzes the conjugation of glutathione to several electrophiles, and it was upregulated in the Trsp f/f -Ucp1-Cre +/− mice, regardless of environmental temperature ( Figure 7 b). On the other hand, Elmod2 , a GTPase activating protein which regulates adipocyte triglyceride lipase recruitment [ 37 ], was found to be significantly upregulated after cold exposure in both genotypes.…”