A C-type lectin that inhibits bacterial infection and facilitates viral invasion in black rockfish, Sebastes schlegelii

Liu, Yong; Li, Ningqiu; Zhao, Xin-peng; Yue, Bin; He, Shuwen; Zhixin, Gao; Zhou, Shun; Zhang, Min

doi:10.1016/j.fsi.2016.08.053

Cited by 25 publications

(3 citation statements)

References 49 publications

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“…Agglutination by mucosal lectins was among others shown for galectin-1 from Atlantic cod [ 17 ], galectin AJL-1 from the Japanese eel, [ 20 ], galectins congerins from the conger eel ( Conger myriaster ) [ 29 ], pufflectin from pufferfish ( Takifugu rubripes ) [ 11 ], rOnMBL from Nile tilapia ( Oreochromis niloticus ) [ 27 ], SsLTL, lily-type lectin from black rockfish ( Sebastes schlegelii ) [ 28 ], CsLTL-1, lily-type lectin from striped murrel, ( Channa striatus ) [ 30 ], a C-type lectin from black rockfish ( Sebastes schlegelii ) [ 31 ], and C-type lectin AJL-2 from the Japanese eel [ 19 ]. Congerin from the skin mucus of the conger eel induce agglutination of Vibrio anguillarum , but not growth inhibition or bacterial killing [ 29 ].…”

Section: The Role Of Mucosal Lectins In Agglutination and Hemagglumentioning

confidence: 99%

“…In vitro the galectins prevented the virus from adhering to fish epithelial cells [ 54 ] where it usually binds to a fibronectin at the cells surface [ 55 ]. Virus uptake can also be stimulated by lectins, for example SsLec1, a C-type lectin from black rockfish ( Sebastes schlegelii ) increases infectious spleen and kidney necrosis virus (ISKNV) copy numbers in black rockfish [ 31 ]. Bacteria on the other hand were efficiently phagocytosed and killed by head kidney macrophages in the presence of SsLec1 [ 31 ], and expression of SsLec1 gene increased when fish were infected with bacteria [ 31 ].…”

Section: Inhibiting Uptake Of Pathogens Inhibiting Colonisation Omentioning

confidence: 99%

“…Virus uptake can also be stimulated by lectins, for example SsLec1, a C-type lectin from black rockfish ( Sebastes schlegelii ) increases infectious spleen and kidney necrosis virus (ISKNV) copy numbers in black rockfish [ 31 ]. Bacteria on the other hand were efficiently phagocytosed and killed by head kidney macrophages in the presence of SsLec1 [ 31 ], and expression of SsLec1 gene increased when fish were infected with bacteria [ 31 ]. This is a clear example of the dual role of lectins where a virus is using a pathway developed for pathogen uptake and clearance to get access to cells and infect the host.…”

Section: Inhibiting Uptake Of Pathogens Inhibiting Colonisation Omentioning

confidence: 99%

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Functional Aspects of Fish Mucosal Lectins—Interaction with Non-Self

et al. 2018

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Mucosal surfaces are of key importance in protecting animals against external threats including pathogens. In the mucosal surfaces, host molecules interact with non-self to prevent infection and disease. Interestingly, both inhibition and stimulation of uptake hinder infection. In this review, the current knowledgebase on teleost mucosal lectins’ ability to interact with non-self is summarised with a focus on agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing activities. Further research on lectins is essential, both to understand the immune system of fishes, since they rely more on the innate immune system than mammals, and also to explore these molecules’ antibiotic and antiparasitic activities against veterinary and human pathogens.

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