Antiviral activity of natural and synthetic β-carbolines against dengue virus

Application of metal free aromatization to total synthesis of perlolyrin, flazin, eudistomin U and harmane

“…Particularly, there are nearly 64 identified β‐carboline alkaloids distributed across the eight plant families. Importantly, aromatic β‐carboline natural products (Figure ) eudistomin U, isoeudistomin, flazin, flazinamide, perlolyrine, harmane and harmine exhibit a wide range of biological activities such as antimalarial, antiviral, neuroprotection, anti‐HIV, anticancer, etc. Therefore, there has been considerable interest in the synthesis of β‐carbolines .…”

Harmine and its derivatives: Biological activities and therapeutic potential in human diseases

“…Moreover, a synthetic derivative of harmine, 9N-methylharmine demonstrates a strong inhibitory effect on DENV-2 generation. The quantification of extracellular and intracellular viral genomes designated that 9N-methylharmine has capability to debilitate maturation time and discharge of viral entities to the extracellular medium influencing the transmission of the disease (Quintana et al, 2016).…”

“…The associated mechanism involves decreased ROS produc- tion, and suppressed EV71-prompted NF-κB activation. Additionally, harmine treatment has a potential to defend AG129 mice against EV71 replication in vivo (Quintana et al, 2016;Chen et al, 2018).…”

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

“…The results indicate that the compounds likely act via viral enzyme inhibition. Harmol (compound 44) and 9-Nmethylharmine (compound 45) were also found to possess inhibitory effects against DENV-1, DENV-3, and DENV-4, albeit with lower efficiencies than against DENV-2 [56]. …”