Brain perfusion alterations in depressed patients with Parkinson’s disease

Kim, Young-Do; Jeong, Hyeok; Song, In‐Uk; Chung, Yong‐An; Namgung, Eun; Kim, Yong-Duk

doi:10.1007/s12149-016-1119-2

Cited by 24 publications

(24 citation statements)

References 39 publications

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“…These results were consistent with previous studies using PET/SPECT and ASL [23,[30][31][32][33], where hypoperfusion was found in widespread cortical regions [20,23], particularly in frontal regions [23,[30][31][32], as well as CN [23], cerebellar regions in PD patients [33]. These areas are often associated with motor function, and cognitive impairments or depression in PD [34,35].…”

Section: Discussionsupporting

confidence: 92%

Discriminative Pattern of Reduced Cerebral Blood Flow in Parkinson's Disease and Parkinsonism-Plus Syndrome: an ASL-MRI study

Cheng

Guo

et al. 2020

Preprint

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Background: Accurate identification of Parkinson's disease (PD) and Parkinsonism-Plus syndrome (PPS), especially in the early stage of the disease, is very important. The purpose of this study was to investigate the discriminative spatial pattern of cerebral blood flow (CBF) between patients with PD and PPS. Methods: Arterial spin labeling (ASL) perfusion-weighted imaging was performed in 20 patients with PD (mean age 56.35±7.56 years), 16 patients with PPS (mean age 59.62±6.89 years), and 17 healthy controls (HCs, mean age 54.17±6.58 years). Voxel-wise comparison of the CBF was performed among PD, PPS, and HC groups. The receiver operating characteristic (ROC) curve was used to evaluate the performance of CBF in discriminating between PD and PPS. The relationship between CBF and non-motor neuropsychological scores was assessed by correlation analysis. Results: PD group showed a significantly decreased CBF in the right cerebelum_crus2, the left middle frontal gyrus (MFG), the triangle inferior frontal gyrus (IFG_Tri), the left frontal medial orbital gyrus (FG_Med_Orb) and the left caudate nucleus (CN) compared with the HC group (P < 0.05). Besides the above regions, the left supplementary motor area (SMA), the right thalamus had decreased CBF in the PPS group compared with the HC group (P < 0.05). PPS group had lower CBF value in the left MFG, the left IFG_Tri, the left CN, the left SMA, and the right thalamus compared with the PD group (P < 0.05). CBFs in left IFG_Tri, the left CN, the left SMA, and the right thalamus had moderate to high capacity in discriminating between PD and PPS patients (AUC 0.719-0.831). The CBF was positively correlated with MMSE and Montreal cognitive assessment (MoCA) scores in PD patients, while positively correlated with the Mini-mental State Examination (MMSE), Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD) scores in PPS patients (P < 0.05). Conclusion: PD and PPS patients have certain discriminative patterns of reduced CBFs, which can be used as a surrogate marker for differential diagnosis.

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Section: Discussionsupporting

confidence: 92%

Discriminative Pattern of Reduced Cerebral Blood Flow in Parkinson's Disease and Parkinsonism-Plus Syndrome: an ASL-MRI study

Cheng

Guo

et al. 2020

Preprint

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“…Participants with incident depression were almost twice as likely to have sOH-30 at wave 1 compared with those without incident depression (linear regression, 13 [95% CI, [8][9][10][11][12][13][14][15][16][17][18][19] versus 7% [95% CI, 6-8]). Proportions of participants with incident depression by OH-30 group are shown in Figure 2.…”

Section: Does Oh-30 At Wave 1 Predict Incident Depression?mentioning

confidence: 99%

“…13 In a cohort with Parkinson disease, single-photon emission computed tomography demonstrated cerebral perfusion deficits in fronto-temporo-limbic regions in depressed participants compared with nondepressed controls. 14 Studies in LLD have also demonstrated increased burden of cerebral white matter disease, specifically strategic white matter hyperintensities (WMH), 15 which can be caused by ischemic insults because of cerebral hypoperfusion. 16,17 WMH are more common and severe in older people with depression, 18 and higher burden of WMH is predictive of increased severity of depressive symptoms, as well as poorer response to treatment in older people.…”

mentioning

confidence: 99%

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

et al. 2018

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There is an established cross-sectional association between orthostatic hypotension (OH) and late-life depression. The aim of this observational study was to clarify the longitudinal association between baseline symptomatic OH (sOH-30) and incident depression in a sample of >3000 older people without baseline depression (mean age: 62 years at baseline). This study was embedded within the Irish Longitudinal Study on Ageing using data from waves 1 to 3, collected between 2009 and 2014. At 2- and 4-year follow-up, a score ≥9 on the 8-item Center for Epidemiological Studies Depression Scale was used to define incident depression. sOH-30 was defined as a drop in systolic blood pressure ≥20 mm Hg or diastolic blood pressure ≥10 mm Hg at 30 seconds post-standing in conjunction with orthostatic symptoms, such as dizziness, using beat-to-beat measurements. Almost one fifth (proportion, 18%; 95% confidence interval [CI], 16-20) of the study sample had sOH-30. One tenth (proportion, 10%; 95% CI, 9-12) had incident depression. Participants with incident depression were twice as likely to have sOH-30 at baseline compared with those without incident depression (linear regression, 13% [95% CI, 8-19] versus 7% [95% CI, 6-8]). Weighted logistic regression models demonstrated that sOH-30 predicted incident depression with an odds ratio of 1.90 (95% CI, 1.15-3.15) after controlling for covariates, including subthreshold depression, hypotension, cognitive impairment, and antidepressant use. Asymptomatic OH at 30 seconds and initial OH did not predict depression. This study demonstrates that sOH-30 predicts incident depression in a population-representative sample of older people and may, therefore, represent a potentially modifiable risk factor for late-life depression.

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“…A meta-analysis revealed that repetitive transcranial magnetic stimulation over the prefrontal cortex exhibited a significant antidepressive effect in PD patients (23). A SPECT study showed that the perfusion in the right medial orbitofrontal cortex was reduced in the depressed PD patients as compared with nondepressed PD patients (24). Sheng et al study with ReHo and FC methods found that PD patients with depression had increased regional activity in the left frontal and medial frontal gyrus when compared with non-depressed PD patients.…”

Section: Discussionmentioning

confidence: 99%

Changed Resting-State Brain Signal in Parkinson's Patients With Mild Depression

et al. 2020

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Background: Depression is reported to occur 5-10 years early than the onset of motor symptoms in Parkinson (PD) patients. However, markers for early diagnosis of PD in individuals with sub-clinical depression still remain to be identified.Purpose: This study utilized Regional Homogeneity (ReHo) to investigate the alterations in resting state brain activities in Parkinson (PD) patients with different degrees of depression.Methods: Twenty non-depressed PD patients, twenty mild to moderately depressed PD patients, and thirteen severely depressed PD patients were recruited. Hamilton Depression Scale (HDS) and the Beck Depression Inventory (BDI) were assessed depression. Resting-state functional magnetic resonance imaging (rs-MRI) was analyzed with ReHo.Results: PD patients with mild to moderate depression had decreased ReHo in the left dorsal anterior cingulate cortex when compared with PD patients without depression. PD patients with severe depression exhibited increased ReHo in the left inferior prefrontal gyrus and right orbitofrontal area when compared with PD patients with mild to moderate depression. ReHo values in the bilateral supplementary motor area (SMA) in PD patients with severe depression was also increased when compared with PD patients without depression. Conclusions:This study suggests that rs-MRI with ReHo analysis can detect early changes in brain function that associate with depression in PD patients, which could be biomarkers for early diagnosis and treatment of PD related depression.

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Brain perfusion alterations in depressed patients with Parkinson’s disease

Abstract: This study identified the regional pattern of brain perfusion that distinguished depressed from nondepressed PD patients. Hyperperfusion in the occipital areas and hypoperfusion in the fronto-temporo-limbic regions may be potential imaging biomarkers for depression in PD.

Cited by 24 publications

References 39 publications

Discriminative Pattern of Reduced Cerebral Blood Flow in Parkinson's Disease and Parkinsonism-Plus Syndrome: an ASL-MRI study

Discriminative Pattern of Reduced Cerebral Blood Flow in Parkinson's Disease and Parkinsonism-Plus Syndrome: an ASL-MRI study

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

Changed Resting-State Brain Signal in Parkinson's Patients With Mild Depression

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