Neuropathic pruritus as the p]resenting symptom of lupus transverse myelitis

González-Sánchez, Marta; Ayuso, Lucía Llorente; Morales, Juan Ruiz; Salio, Antonio Martínez

doi:10.1016/j.jns.2016.06.070

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Cutaneous Lupus Erythematosus (Cle)1

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“…Small fiber damage and decreased IENF density (IENFD) were found in patients with SLE [ 25 ]. Neuropathic itch as an initial presentation in a patient with lupus transverse myelitis has been reported [ 26 ]. This indicates that neuropathic itch might participate in the pathogenesis of CLE-related pruritus.…”

Section: Cutaneous Lupus Erythematosus (Cle)mentioning

confidence: 99%

Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms

Wong

Yen

2022

Diagnostics

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Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which affect their quality of life. However, it is rarely recognized both by patients and physicians. Meanwhile, pruritus is not only a symptom but is also related to the disease severity of some ACTDs. The pathophysiology of ACTD related pruritus is ambiguous. This review summarizes the features and possible mechanisms of ACTD-related pruritus, which might lead to proper diagnosis and treatment.

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Section: Cutaneous Lupus Erythematosus (Cle)mentioning

confidence: 99%