Autoimmune Connective Tissue Diseases-Related Pruritus: Proper Diagnosis and Possible Mechanisms

Abstract

Pruritus is a well-known bothersome symptom among skin disorders, especially inflammatory skin disorders. Lately, a high prevalence of pruritus in patients with autoimmune connective tissue diseases (ACTDs) has been revealed. Patients with ACTDs may suffer from varying degrees of pruritus, which affect their quality of life. However, it is rarely recognized both by patients and physicians. Meanwhile, pruritus is not only a symptom but is also related to the disease severity of some ACTDs. The pathophysiology of ACTD related pruritus is ambiguous. This review summarizes the features and possible mechanisms of ACTD-related pruritus, which might lead to proper diagnosis and treatment.

Recalcitrant pruritus: A heralding sign of primary Sjogren's syndrome

“…3 Paraneoplastic pruritus may be another rational explanation for SS associated with neoplasm. 7 The lack of response of SSrelated pruritus to immunosuppressives indicates that SS-related damage instead of inflammation causes pruritus. 8…”