In-vivo validation of a new clinical tool to quantify three-dimensional myocardial strain using ultrasound

Bouchez, Stefaan; Heyde, Brecht; Barbosa, Daniel; Vandenheuvel, Michaël; Houle, Hélène; Wang, Yan; D'hooge, Jan; Wouters, Patrick

doi:10.1007/s10554-016-0962-5

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…The impact of Dobutamine and Verapamil on the rest of the mechanic and hemodynamic parameters was comparable. In line with previous reproducibility studies [39][40][41][42], we showed that radial strain is a poorly reproducible and inaccurate measurement. In this study we did not show the interand intra-observer reproducibility because it was already assessed in a previous work from our group based on the same cohort [43].…”

Section: Relative Change Of Mechanics Under Various Inotropic Statessupporting

confidence: 90%

Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine

Faragli

Tanacli

Kolp

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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Background Cardiovascular magnetic resonance (CMR) strain imaging is an established technique to quantify myocardial deformation. However, to what extent left ventricular (LV) systolic strain, and therefore LV mechanics, reflects classical hemodynamic parameters under various inotropic states is still not completely clear. Therefore, the aim of this study was to investigate the correlation of LV global strain parameters measured via CMR feature tracking (CMR-FT, based on conventional cine balanced steady state free precession (bSSFP) images) with hemodynamic parameters such as cardiac index (CI), cardiac power output (CPO) and end-systolic elastance (Ees) under various inotropic states. Methods Ten anaesthetized, healthy Landrace swine were acutely instrumented closed-chest and transported to the CMR facility for measurements. After baseline measurements, two steps were performed: (1) dobutamine-stress (Dobutamine) and (2) verapamil-induced cardiovascular depression (Verapamil). During each protocol, CMR images were acquired in the short axisand apical 2Ch, 3Ch and 4Ch views. MEDIS software was utilized to analyze global longitudinal (GLS), global circumferential (GCS), and global radial strain (GRS). Results Dobutamine significantly increased heart rate, CI, CPO and Ees, while Verapamil decreased them. Absolute values of GLS, GCS and GRS accordingly increased during Dobutamine infusion, while GLS and GCS decreased during Verapamil. Linear regression analysis showed a moderate correlation between GLS, GCS and LV hemodynamic parameters, while GRS correlated poorly. Indexing global strain parameters for indirect measures of afterload, such as mean aortic pressure or wall stress, significantly improved these correlations, with GLS indexed for wall stress reflecting LV contractility as the clinically widespread LV ejection fraction. Conclusion GLS and GCS correlate accordingly with LV hemodynamics under various inotropic states in swine. Indexing strain parameters for indirect measures of afterload substantially improves this correlation, with GLS being as good as LV ejection fraction in reflecting LV contractility. CMR-FT-strain imaging may be a quick and promising tool to characterize LV hemodynamics in patients with varying degrees of LV dysfunction.

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Section: Relative Change Of Mechanics Under Various Inotropic Statessupporting

confidence: 90%

Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine

Faragli

Tanacli

Kolp

et al. 2020

Journal of Cardiovascular Magnetic Resonance

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“…Generally, while LS 2DSTE seems to perform well across studies, recent reports describe suboptimal correlation and larger bias for CS and RS by 2DSTE 56 . For 3DSTE, LS and CS are accurate compared to sonomicrometry, while RS has been shown to be less reliable 59 . To date, FT has not been tested in vivo .…”

Section: Practical Aspectsmentioning

confidence: 96%

Myocardial strain imaging: review of general principles, validation, and sources of discrepancies

Amzulescu

Craene

Langet

et al. 2019

European Heart Journal - Cardiovascular Imaging

351

309

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Myocardial tissue tracking imaging techniques have been developed for a more accurate evaluation of myocardial deformation (i.e. strain), with the potential to overcome the limitations of ejection fraction (EF) and to contribute, incremental to EF, to the diagnosis and prognosis in cardiac diseases. While most of the deformation imaging techniques are based on the similar principles of detecting and tracking specific patterns within an image, there are intra- and inter-imaging modality inconsistencies limiting the wide clinical applicability of strain. In this review, we aimed to describe the particularities of the echocardiographic and cardiac magnetic resonance deformation techniques, in order to understand the discrepancies in strain measurement, focusing on the potential sources of variation: related to the software used to analyse the data, to the different physics of image acquisition and the different principles of 2D vs. 3D approaches. As strain measurements are not interchangeable, it is highly desirable to work with validated strain assessment tools, in order to derive information from evidence-based data. There is, however, a lack of solid validation of the current tissue tracking techniques, as only a few of the commercial deformation imaging softwares have been properly investigated. We have, therefore, addressed in this review the neglected issue of suboptimal validation of tissue tracking techniques, in order to advocate for this matter.

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“…3D strain analysis was done offline by a single viewer blinded to the clinical, laboratory, and conventional echocardiography study interpretation. All the 3D datasets were processed using a software package for automated volumetric strain analysis -EchobuildR 3D Volume Analysis prototype software, v3.0 2019, SMS [14][15][16]. The software generated 3D endocardial LV, RV, LA, and RA volumes (Fig.…”

Section: Methodsmentioning

confidence: 99%

Unmasking Myocardial Dysfunction in Patients Hospitalized for Community-Acquired Pneumonia Using a 4-Chamber 3-Dimensional Volume/Strain Analysis

et al. 2022

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Lower respiratory infection was reported as the most common fatal infectious disease. Community-acquired pneumonia (CAP) and myocardial injury are associated; yet, true prevalence of myocardial injury is probably underestimated. We assessed the rate and severity of myocardial dysfunction in patients with CAP. Admitted patients diagnosed with CAP were prospectively recruited. All the patients had C-reactive protein (CRP), brain natriuretic peptide (BNP), and high-sensitivity cardiac troponin (hs-cTnl) tests added to their routine workup. 2D/3D Doppler echocardiography was done on a Siemens Acuson SC2000 machine ≤ 24 h of diagnosis. 3D datasets were blindly analyzed for 4-chamber volumes/strains using EchobuildR 3D-Volume Analysis prototype software, v3.0 2019, Siemens-Medical Solutions. Volume/strain parameters were correlated with admission clinical and laboratory findings. The cohort included 34 patients, median age 60 years (95% CI 55-72). The cohort included 18 (53%) patients had hypertension, 9 (25%) had diabetes mellitus, 7 (21%) were smokers, 7 (21%) had previous myocardial infarction, 4 (12%) had chronic renal failure, and 1 (3%) was on hemodialysis treatment. 2D/Doppler echocardiography findings showed normal ventricular size/function (LVEF 63 ± 9%), mild LV hypertrophy (104 ± 36 g/m 2 ), and LA enlargement (41 ± 6 mm). 3D volumes/strains suggested bi-atrial and right ventricular dysfunction (global longitudinal strain RVGLS = − 8 ± 4%). Left ventricular strain was normal (LVGLS = − 18 ± 5%) and correlated with BNP (r = 0.40, p = 0.024). The patients with LVGLS > − 17% had higher admission blood pressure and lower SaO 2 (144 ± 33 vs. 121 ± 20, systolic, mmHg, p = 0.02, and 89 ± 4 vs. 94 ± 4%, p = 0.006, respectively). hs-cTnl and CRP were not different. Using novel 3D volume/strain software in CAP patients, we demonstrated diffuse global myocardial dysfunction involving several chambers. The patients with worse LV GLS had lower SaO 2 and higher blood pressure at presentation. LV GLS correlated with maximal BNP level and did not correlate with inflammation or myocardial damage markers.

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In-vivo validation of a new clinical tool to quantify three-dimensional myocardial strain using ultrasound

Cited by 6 publications

References 33 publications

Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine

Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine

Myocardial strain imaging: review of general principles, validation, and sources of discrepancies

Unmasking Myocardial Dysfunction in Patients Hospitalized for Community-Acquired Pneumonia Using a 4-Chamber 3-Dimensional Volume/Strain Analysis

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