Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine

Faragli, Alessandro; Tanacli, Radu; Kolp, C.; Abawi, Dawud; Lapinskas, Tomas; Stehning, Christian; Schnackenburg, Bernhard; Muzio, Francesco Paolo Lo; Fassina, Lorenzo; Pieske, Burkert; Nagel, Eike; Post, Heiner; Kelle, Sebastian; Alogna, Alessio

doi:10.1186/s12968-020-00679-z

Cited by 8 publications

(12 citation statements)

References 46 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hemodynamic and the CMR-based geometrical and functional parameters of the pigs at rest, under dobutamine and under verapamil, are reported in Table 1. The following hemodynamic data have been previously published (17), where a significant increase of HR, mean aortic pressure, and CPO under Dob and a respective significant decrease during Ver were observed; stroke volume and LVEF did not decrease significantly under Dob but decreased significantly instead during Ver.…”

Section: Resultsmentioning

confidence: 56%

“…Data from n = 10 (51 ± 10 kg) Landrace pigs were selected from an already published study cohort from our group (16,17), where dobutamine stress testing and verapamil ischemia induction were performed. Female Landrace swine were fasted overnight with free access to water and then sedated and intubated on the day of the experiment.…”

Section: Methodsmentioning

confidence: 99%

“…The experimental protocol has been already described in two published papers from our group (16,17). Briefly, female Landrace pigs (n = 10, weight = 51 ± 10 kg) were acutely instrumented, and the animals were transported to the MRI facility for measurements.…”

Section: Experimental Protocolmentioning

confidence: 99%

“…The experimental protocols were approved by the local bioethics committee of Berlin, Germany (G0138/ 17)…”

Section: Data Availability Statementmentioning

confidence: 99%

“…Internal myocardial power [baseline: 5.9 (4.6-8.5) W/m 2 ] was not affected by dobutamine [7.5 (6.9-9.0) W/m 2 , p = 0.241] nor verapamil [5.8 (4.7-8.8) W/m 2 , p = 0.878]. Myocardial efficiency did not change from baseline to dobutamine [21% (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) vs. 31% , p = 0.059] but decreased significantly during verapamil-induced ischemia [10% (8)(9)(10)(11)(12)(13), p = 0.005].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

Faragli

Alogna

Lee

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Myocardial efficiency should be maintained stable under light-to-moderate stress conditions, but ischemia puts the myocardium at risk for impaired functionality. Additionally, the measurement of such efficiency typically requires invasive heart catheterization and exposure to ionizing radiation. In this work, we aimed to non-invasively assess myocardial power and the resulting efficiency during pharmacological stress testing and ischemia induction.Methods: In a cohort of n = 10 healthy Landrace pigs, dobutamine stress testing was performed, followed by verapamil-induced ischemia alongside cardiac magnetic resonance (CMR) imaging. External myocardial power, internal myocardial power, and myocardial efficiency were assessed non-invasively using geometrical and functional parameters from CMR volumetric as well as blood flow and pressure measurements.Results: External myocardial power significantly increased under dobutamine stress [2.3 (1.6–3.1) W/m2 vs. 1.3 (1.1–1.6) W/m2, p = 0.005] and significantly decreased under verapamil-induced ischemia [0.8 (0.5–0.9) W/m2, p = 0.005]. Internal myocardial power [baseline: 5.9 (4.6–8.5) W/m2] was not affected by dobutamine [7.5 (6.9–9.0) W/m2, p = 0.241] nor verapamil [5.8 (4.7–8.8) W/m2, p = 0.878]. Myocardial efficiency did not change from baseline to dobutamine [21% (15–27) vs. 31% (20–44), p = 0.059] but decreased significantly during verapamil-induced ischemia [10% (8–13), p = 0.005].Conclusion: In healthy Landrace pigs, dobutamine stress increased external myocardial power, whereas myocardial efficiency was maintained stable. On the contrary, verapamil-induced ischemia substantially decreased external myocardial power and myocardial efficiency. Non-invasive CMR was able to quantify these efficiency losses and might be useful for future clinical studies evaluating the effects of therapeutic interventions on myocardial energetics.

show abstract

Section: Resultsmentioning

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Experimental Protocolmentioning

confidence: 99%

“…The experimental protocols were approved by the local bioethics committee of Berlin, Germany (G0138/ 17)…”

Section: Data Availability Statementmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

Faragli

Alogna

Lee

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

Pulmonary 4D-flow MRI imaging in landrace pigs under rest and stress

Faragli,

Hüllebrand,

Berendsen

et al. 2024

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

Abstract4D-flow MRI is a promising technique for assessing vessel hemodynamics. However, its utilization is currently limited by the lack of reference values, particularly for pulmonary vessels. In this work, we have analysed flow and velocity in the pulmonary trunk (PT), left and right pulmonary arteries (LPA and RPA, respectively) in Landrace pigs at both rest and stress through the software MEVISFlow. Nine healthy Landrace pigs were acutely instrumented closed-chest and transported to the CMR facility for evaluation. After rest measurements, dobutamine was administered to achieve a 25% increase in heart rate compared to rest. 4D-flow MRI images have been analysed through MEVISFlow by two independent observers. Inter- and intra-observer reproducibility was quantified using intraclass correlation coefficient. A significant difference between rest and stress regarding flow and velocity in all the pulmonary vessels was observed. Mean flow increased 55% in PT, 75% in LPA and 40% in RPA. Mean peak velocity increased 55% in PT, 75% in LPA and 66% in RPA. A good-to-excellent reproducibility was observed in rest and stress for flow measurements in all three arteries. An excellent reproducibility for velocity was found in PT at rest and stress, a good one for LPA and RPA at rest, while poor reproducibility was found at stress. The current study showed that pulmonary flow and velocity assessed through 4D-flow MRI follow the physiological alterations during cardiac cycle and after stress induced by dobutamine. A clinical translation to assess pulmonary diseases with 4D-flow MRI under stress conditions needs investigation.

show abstract

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

Zinno,

Agnesi,

D'Alesio

et al. 2024

APL Bioengineering

View full text Add to dashboard Cite

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive measurements even if, in the latest years, invasive microelectromechanical systems (MEMS) sensors have emerged as a valuable approach for precise and continuous monitoring of cardiac activity. The main challenges in designing cardiac MEMS sensors are represented by miniaturization, biocompatibility, and long-term stability. Here, we present a MEMS piezoresistive cardiac sensor capable of continuous monitoring of LV activity over time following epicardial implantation with a pericardial patch graft in adult minipigs. In acute and chronic scenarios, the sensor was able to compute heart rate with a root mean square error lower than 2 BPM. Early after up to 1 month of implantation, the device was able to record the heart activity during the most important phases of the cardiac cycle (systole and diastole peaks). The sensor signal waveform, in addition, closely reflected the typical waveforms of pressure signal obtained via intraventricular catheters, offering a safer alternative to heart catheterization. Furthermore, histological analysis of the LV implantation site following sensor retrieval revealed no evidence of myocardial fibrosis. Our results suggest that the epicardial LV implantation of an MEMS sensor is a suitable and reliable approach for direct continuous monitoring of cardiac activity. This work envisions the use of this sensor as a cardiac sensing device in closed-loop applications for patients undergoing heart surgery.

show abstract

Cardiovascular magnetic resonance-derived left ventricular mechanics—strain, cardiac power and end-systolic elastance under various inotropic states in swine

Cited by 8 publications

References 46 publications

Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

Non-invasive CMR-Based Quantification of Myocardial Power and Efficiency Under Stress and Ischemic Conditions in Landrace Pigs

Pulmonary 4D-flow MRI imaging in landrace pigs under rest and stress

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

Contact Info

Product

Resources

About