Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer’s disease

He, Xi; Yang, Xiao Hong; Ou, Rui; Ouyang, Ying; Wang, Sheng Nan; Chen, Zi Wei; Wen, Shulin; Pi, Rong biao

doi:10.1080/14786419.2016.1219862

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…Additionally, mice treatment with caffeic acid and ferulic acid attenuated the effects of iron overload on the rat serum biochemical parameters [42][43][44]. Strikingly, ferulic and caffeic acid supplementation have shown positive effects toward prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model [45], multifunctional properties against Alzheimer's disease (AD) [46], and the anti-cancer activity has been demonstrated by their ability to mediate Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties DOI: http://dx.doi.org/10.5772/intechopen.1004522 cytotoxicity toward human breast cancer cell lines that in the future could be profitably applied for chemopreventive and/or chemotherapeutic purposes [47].…”

Section: Phenolic Acidsmentioning

confidence: 99%

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Požgajová,

Klongová,

Kovár

et al. 2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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Stress caused by challenging environmental conditions is often associated with the rapid production of reactive oxygen species (ROS) that dramatically alter cellular redox homeostasis. ROS generation is tightly connected with its utilization, as impaired equilibrium of these processes results in oxidative stress having profound consequences for cell physiology. The balanced action of both antioxidant enzymes and non-enzymatic antioxidants counterbalances the harmful effects of ROS. Despite the functional antioxidant system of the cell, excessive ROS leads to disruption of vital cellular processes which is associated with the development of various lifestyle diseases, mainly cardiovascular diseases, and cancer. Enhanced consumption of foodstuffs with high and balanced antioxidant bioactive compounds is linked with the positive effects of beneficial antioxidants impacting cellular protection resulting in health promotion. In this chapter, we present an outline of how bioactive compounds determine their health-promoting properties.

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Section: Phenolic Acidsmentioning

confidence: 99%

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Požgajová,

Klongová,

Kovár

et al. 2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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“…In addition to direct application, scholars synthesized a series of dimers from caffeic acid and ferulic acid, and found that they could effectively remove DPPH and strongly inhibit the self-induced aggregation of Aβ (1-42) (He et al, 2017). In contrast, the prepared crystalline caffeic acid also showed neuroprotective effect as well as biological effects on AD on R28 cell line with the addition amount less than 6 μg/mL (Khan et al, 2016).…”

Section: Caffeic Acidmentioning

confidence: 99%

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Rang

Liu

et al. 2023

Phytotherapy Research

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Alzheimer's disease (AD) is one of the major neurological disorders causing death in the elderly worldwide. As a neurodegenerative disease that is difficult to prevent and cure, the pathogenesis of AD is complex and there is no effective cure. A variety of natural products derived from plants have been reported to have promising anti‐AD activities, including flavonoids, terpenes, phenolic acids and alkaloids, which can effectively relieve the symptoms of AD in a variety of ways. This paper mainly reviews the pharmacological activity and mechanisms of natural products against AD. Although the clinical efficacy of these plants still needs to be determined by further high‐quality studies, it may also provide a basis for future researchers to study anti‐AD in depth.

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“…Moreover, compound 50 (Fig. 25 ) also showed potent protective effects against glutamate-induced cell death without significant cell toxicity in mouse hippocampal neuronal HT22 cells, whereas 51 effectively scavenged diphenyl-1-picrylhydrazyl (DPPH) free radicals assay [ 147 ].…”

Section: Curcumin Derivatives and Analoguesmentioning

confidence: 99%

Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

Viegas

Gontijo

Silva

et al. 2022

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: Nowadays, neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), represent a great challenge for different scientific fields, such as neuropharmacology, medicinal chemistry, molecular biology, and medicine, once all these pathologies remain incurable, with high socio-economic impacts and high costs for governmental health services. Due to their severity and multifactorial pathophysiological complexity, the available approved drugs for clinics have not yet shown adequate effectiveness in disease-modifying effects, with very restricting options in the therapeutic arsenal, which highlight the permanent need for continued drug discovery efforts in Academia and Industry. In this context, natural products, such as curcumin (1), resveratrol (2), and cannabidiol (CBD, 3) have been recognized as important sources of inspiration, promising chemical entities, prototype models, and starting materials for medicinal organic chemistry. Once their molecular architecture, multifunctional properties and single chemical diversity could address the discovery, optimization, and development of innovative drug candidates with improved pharmacodynamics and pharmacokinetics compared to the known drugs, there may be a real chance of discovering novel effective drugs to combat NDs. In this review, we report the most recent efforts of medicinal chemists worldwide, published in the scientific literature available in PubMed, SCOPUS, and Web of Sciences database, during the last 10 years of research devoted to the exploration of curcumin (1), resveratrol (2) and cannabidiol (CBD, 3) as starting materials or privileged scaffolds in the design of multi-target directed ligands (MTDLs) with potential therapeutic properties against NDs.

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Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer’s disease

Cited by 12 publications

References 13 publications

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Cell Protection by Oxidative Stress Mitigation Using Substances with Bioactive Properties

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents

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