The inhibitory effect of dehydroepiandrosterone and its derivatives against influenza A virus in vitro and in vivo

Yang, Qingyu; Mao, Qinghe; Liu, Manli; Wang, Kaimei; Wu, Zhimin; Fang, Wei; Yang, Ziwen; Luo, Pengchen; Ke, Shaoyong; Shi, Liqiao

doi:10.1007/s00705-016-2993-6

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…We predict that TCM can treat diseases through metabolism. DHEA is a key metabolite of cholesterol and affects the inflammatory response of animals (Zhao et al, 2020 ), and has been shown to affect immune function (Yang et al, 2016 ). DHEA appears to treat E. coli ‐induced enteritis in mice through reducing the expression of pro‐inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Wang

et al. 2022

Microbial Biotechnology

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Endometritis is persistent inflammation caused by bacteria, which can lead to infertility. Although traditional Chinese medicine (TCM) has been used to treat endometritis, the underlying mechanism is still unclear. Here, Baogong Decoction (BGD), a TCM compound, was used to treat mouse endometritis induced by Escherichia coli (E. coli), and then 16S rRNA sequencing and non-targeted metabolomics were used to investigate the change of uterine microbiota and metabolomes in serum and uterine after BGD treatment.Finally, the therapeutic effect of potential metabolites for treating mouse endometritis screened by combined omics analyses was verified using pathological model. The results showed that BGD treatment could effectively treat endometritis associated with the increasing relative abundance of Firmicutes, Bacteroides, Lactobacillus and Lactococcus, and the decreasing relative abundance of Cupriavidus and Proteobacteria. 133 and 130 metabolites were found to be potential biomarkers in serum and uterine tissue respectively.In serum and tissues, dehydroepiandrosterone (DHEA) and catechol were significantly increased in the BGD treatment versus the inflammation group.Results of combined omics analyses demonstrated that DHEA was positively correlated with changes in microbiota. Results of pathological model demonstrated that DHEA could cure endometritis effectively associated with the decreasing infiltration of inflammatory cells and expression of inflammatory factors in the uterus. In summary, our results demonstrated that BGD could cure endometritis in mice by modulating the structure of the uterine microbiota and its metabolites, in which DHEA may be one of the main components of the therapeutic effect of BGD.

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Section: Discussionmentioning

confidence: 99%

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Wang

et al. 2022

Microbial Biotechnology

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“…The antiviral properties of steroidal bioconjugates have also been explored and reported. Qingyu Yang et al developed some dehydroepiandrosterone (DHEA) based bioconjugates having potent efficacy against DNA and RNA viruses . Among the several synthesized compounds, DHEA-conjugate 110 bearing a 2-OH-Ph moiety (Figure ) exhibited the best inhibitory effects against H1N1 and H3N2 influenza virus type A (IAV) in a dose-dependent manner.…”

Section: Therapeutic Potential Of Steroidal Bioconjugatesmentioning

confidence: 99%

“…Qingyu Yang et al developed some dehydroepiandrosterone (DHEA) based bioconjugates having potent efficacy against DNA and RNA viruses. 217 Among the several synthesized compounds, DHEA-conjugate 110 bearing a 2-OH-Ph moiety ( Figure 24 ) exhibited the best inhibitory effects against H1N1 and H3N2 influenza virus type A (IAV) in a dose-dependent manner. Treatment with conjugate 110 decreased progeny virus yield, viral RNA synthesis, and protein expression.…”

Section: Therapeutic Potential Of Steroidal Bioconjugatesmentioning

confidence: 99%

A Comprehensive Review on Steroidal Bioconjugates as Promising Leads in Drug Discovery

Bansal

Suryan

2022

ACS Bio Med Chem Au

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Ever increasing unmet medical requirements of the human race and the continuous fight for survival against variety of diseases give birth to novel molecules through research. As diseases evolve, different strategies are employed to counter the new challenges and to discover safer, more effective, and target-specific therapeutic agents. Among several novel approaches, bioconjugation, in which two chemical moieties are joined together to achieve noticeable results, has emerged as a simple and convenient technique for a medicinal chemist to obtain potent molecules. The steroid system has been extensively used as a privileged scaffold gifted with significantly diversified medicinal properties in the drug discovery and development process. Steroidal molecules are preferred for their rigidness and good ability to penetrate biological membranes. Slight alteration in the basic ring structure results in the formation of steroidal derivatives with a wide range of therapeutic activities. Steroids are not only active as such, conjugating them with various biologically active moieties results in increased lipophilicity, stability, and target specificity with decreased adverse effects. Thus, the steroid nucleus prominently behaves as a biological carrier for small molecules. The steroid bioconjugates offer several advantages such as synergistic activity with fewer side effects due to reduced dose and selective therapy. The steroidal bioconjugates have been widely explored for their usefulness against various disorders and have shown significant utility as anticancer, anti-inflammatory, anticoagulant, antimicrobial, insecticidal/pesticidal, antioxidant, and antiviral agents along with several other miscellaneous activities. This work provides a comprehensive review on the therapeutic progression of steroidal bioconjugates as medicinally active molecules. The review covers potential biological applications of steroidal bioconjugates and would benefit the wider scientific community in their drug discovery endeavors.

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“…Oral DHEA replacement in Addison's disease leads to restoration of levels of regulatory T cells and the decrease in the NK cells (Coles et al 2005). The inhibitory effect of DHEA analogs in viral multiplication has been demonstrated in influenza A virus infection where it inhibited the viral infection in the post-attachment stage (Yang et al 2016).…”

Section: Dhea Supplementationmentioning

confidence: 99%

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

Tomo

Banerjee

Sharma

et al. 2021

Endocrine Regulations

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The pathophysiology of COVID comprises an exaggerated pro-inflammatory response. Hypothalamic-pituitary-adrenal (HPA) axis has a crucial role in various inflammatory conditions and modulated immunological response. Limited evidence is available regarding the incidence and the effect of HPA dysfunction in COVID-19. Although the cortisol levels have only been estimated in a few studies, the dehydroepiandrosterone sulfate (DHEAS) release from the adrenal gland has not been explored yet. In this mini review, the authors discuss the role of dehydroepiandrosterone (DHEA) and DHEAS in the acute stress response and immunological modulation. Various effects of DHEAS have been demonstrated in different diseases. The specific inhibitory effect of DHEA on interleukin 6 (IL-6) could be of paramount importance in COVID-19. Further, DHEA supplementation has already been proposed in inflammatory conditions, like rheumatoid arthritis. DHEAS levels in COVID-19 may help to understand the HPA axis dysfunction as well as the possibility of repurposing DHEA as a drug for mitigating the pro-inflammatory COVID-19.

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The inhibitory effect of dehydroepiandrosterone and its derivatives against influenza A virus in vitro and in vivo

Cited by 13 publications

References 27 publications

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites

A Comprehensive Review on Steroidal Bioconjugates as Promising Leads in Drug Discovery

Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

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