Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

Tomo, Sojit; Banerjee, Mithu; Sharma, Praveen; Garg, Mahendra Kumar

doi:10.2478/enr-2021-0019

Cited by 10 publications

(9 citation statements)

References 74 publications

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“…However, few human studies have explored the effects of DHEA supplementation in sepsis. The decrease in DHEAS in COVID-19 patients opens up the possibility of exploring DHEA as adjuvant therapy in COVID-19, as previously illustrated by the authors [ 12 ].…”

Section: Discussionmentioning

confidence: 65%

Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study

et al. 2022

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Purpose Dehydroepiandrosterone sulfate (DHEAS) is observed to be decreased in sepsis and inflammatory conditions. In the present study, we assessed the levels of DHEAS and cortisol and the DHEAS/cortisol ratio and their association with inflammatory markers in patients with COVID-19. Methods The study recruited 76 RT-PCR-positive COVID-19-positive patients and 79 healthy controls. The blood samples were collected and were analyzed for cortisol and DHEAS. Results We observed decreased levels of DHEAS and DHEAS/cortisol ratio and increased levels of cortisol in cases when compared with controls. DHEAS and DHEAS/cortisol ratio showed a decreasing trend with the increase in disease severity. Conclusion The present study is the first of its kind comparing DHEAS levels and DHEAS/cortisol ratio in COVID-19 patients and control subjects. DHEAS, with its inhibitory effect on IL6 and activation of Tregs, may play a crucial role in immune defense mechanisms against COVID-19. Supplementary Information The online version contains supplementary material available at 10.1007/s42000-022-00382-x.

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Section: Discussionmentioning

confidence: 65%

Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study

et al. 2022

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“…DHEAS has an immunostimulatory effect. DHEA is more sensitive to HPA axis stimulation than cortisol [ 20 , 21 ]. However, its relationship with the severity of COVID-19 has not been evaluated.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity

et al. 2022

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Purpose This study aims to evaluate the correlations between the severity of the disease and serum steroid levels by analyzing the serum steroid levels in COVID-19 patients with different levels of disease progression and the control group. Methods Morning serum Aldosterone, 11-deoxycortisol, Androstenedione, 17-hydroxyprogesterone, Dihydrotestosterone (DHT), Dehydroepiandrosterone (DHEA), Corticosterone, Dehydroepiandrosterone sulfate (DHEAS), Estrone, Estradiol, Progesterone, 11-deoxycorticosterone, Cortisol, Corticosterone, Androsterone, Pregnenolone, 17-hydroxypregnenolone and 21-deoxycortisol levels were measured in 153 consecutive patients were grouped as mild, moderate, and severe based on the WHO COVID-19 disease severity classification and the control group. Steroid hormone levels were analyzed at once with a liquid chromatography-tandem mass spectrometric method (LC-MS/MS). Results In our study, nearly all steroids were statistically significantly higher in the patients’ group than in the control group ( p < 0.001). Also, DHEA was an independent indicator of the disease severity with COVID-19 Conclusions Our study reveals that the alteration in steroid hormone levels was correlated with disease severity. Also, steroid hormone levels should be followed up during COVID-19 disease management.

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“…So, adjust the gabapentin dose based on renal function. 116 As information from the previous study, DHEA sulfate has a function in COVID-19 prognosis, and therapy 117 and DHEA is used to treat ARDS in COVID-19 sufferers. 118 signs of COVID-19 that are severe seem to be more likely in people with higher levels of circulating androgens.…”

Section: Discussionmentioning

confidence: 97%

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Rahman

Amin

Yeasmin

et al. 2023

Bioinform Biol Insights

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The COVID-19 coronavirus, which primarily affects the lungs, is the source of the disease known as SARS-CoV-2. According to “Smoking and COVID-19: a scoping review,” about 32% of smokers had a severe case of COVID-19 pneumonia at their admission time and 15% of non-smokers had this case of COVID-19 pneumonia. We were able to determine which genes were expressed differently in each group by comparing the expression of gene transcriptomic datasets of COVID-19 patients, smokers, and healthy controls. In all, 37 dysregulated genes are common in COVID-19 patients and smokers, according to our analysis. We have applied all important methods namely protein-protein interaction, hub-protein interaction, drug-protein interaction, tf-gene interaction, and gene-MiRNA interaction of bioinformatics to analyze to understand deeply the connection between both smoking and COVID-19 severity. We have also analyzed Pathways and Gene Ontology where 5 significant signaling pathways were validated with previous literature. Also, we verified 7 hub-proteins, and finally, we validated a total of 7 drugs with the previous study.

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Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?

Cited by 10 publications

References 74 publications

Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study

Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study

COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

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