Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients

Bonfigli, Anna Rita; Boemi, Massimo; Festa, Roberto; Bonazzi, Patrizia; Brandoni, Gabriele; Spazzafumo, Liana; Olivieri, Fabiola; Ceriello, Antonio; Genovese, Stefano; Testa, Roberto

doi:10.1016/j.numecd.2016.06.012

Cited by 29 publications

(34 citation statements)

References 36 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association between H pylori and gestational diabetes mellitus was found in this study. A recent publication demonstrated that the elimination of H pylori infection improved glucose metabolism in patients with type 2 diabetes . The association could be explained by some biological mechanisms.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Zhan

et al. 2019

Helicobacter

View full text Add to dashboard Cite

Objective To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes. Materials and Methods A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Subgroup analysis and sensitivity analysis were performed. Results Thirty‐one studies with a total of 22 845 participants were identified. There was significant association of H pylori infection with preeclampsia (OR: 2.51; 95% CI: 1.88‐3.34; P < 0.001), fetal growth restriction (OR: 2.28; 95% CI: 1.21‐4.32; P = 0.01), gestational diabetes mellitus (OR: 2.03; 95% CI: 1.56‐2.64; P < 0.001), spontaneous abortion (OR: 1.50; 95% CI: 1.05‐2.14; P = 0.024), and birth defect (OR: 1.63; 95% CI: 1.05‐2.54; P = 0.03). Sensitivity analysis showed the significant association between H pylori infection and low birthweight (OR: 1.59; 95% CI: 1.05‐2.40; P = 0.03). Conclusion The present meta‐analysis offers proof to support that H pylori infection during pregnancy can increase the risk on adverse pregnancy outcomes. Screening and treating for H pylori infection before pregnancy should be taken into account.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A recent publication demonstrated that the elimination of H pylori infection improved glucose metabolism in patients with type 2 diabetes. 56 The association could be explained by some biological mechanisms. First, changes in glucose metabolism might lead to chemical alterations in the gastric mucosa that P < 0.0001).…”

Section: Discussionmentioning

confidence: 99%

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Zhan

et al. 2019

Helicobacter

View full text Add to dashboard Cite

show abstract

“…It was reported that H. pylori eradication improved the mean glycated hemoglobin in patients with type 2 diabetes, however, whether H. pylori eradication improves glycemic control is also controversial. Recent randomized trial showed that H. pylori eradication improves glucose homeostasis in patients with type 2 diabetes through a decrease in pro‐inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Kato

Toda

Yamamoto‐Honda

et al. 2019

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction It is suspected that Helicobacter pylori is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between H. pylori and diabetes, and the results were conflicting. The aim of the present study was to examine the association between H. pylori infection, eradication and diabetes. Materials and Methods The present cross‐sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of H. pylori infection, determined by serum antibodies and history of eradication, was categorized into three groups as “never,” “current” and “past.” The association between H. pylori infection and diabetes was examined using logistic regression. Results Of 21,634 participants, 6,530 (30.2%) had a current or past history of H. pylori infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the “never” group were 1.36 (95% confidence interval 1.10–1.67) for the “current” group and 0.92 (95% confidence interval 0.79–1.07) for the “past” group. The association between H. pylori infection and diabetes was also observed among participants without a history of eradication. Conclusions We found that current H. pylori infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that H. pylori infection increases the risk of diabetes. Further studies are necessary to validate the present results.

show abstract

“…Moreover, a recent randomized double-blind placebo-controlled trial demonstrated that H. pylori eradication improves glucose homeostasis in patients with type 2 diabetes by decreasing HOMA-IR and fasting insulin levels (Bonfigli et al, 2016). In a previous study, we also found in Mongolian gerbils that long-term H. pylori infection induced increased levels of HbA1c, but its effect on glucose tolerance and the underlying mechanism remains unclear (Yang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice

Yang

Cheng

et al. 2016

EBioMedicine

View full text Add to dashboard Cite

Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR. Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD. There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.

show abstract

Randomized, double-blind, placebo-controlled trial to evaluate the effect of Helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients

Cited by 29 publications

References 36 publications

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

The risk ofHelicobacter pyloriinfection for adverse pregnancy outcomes: A systematic review and meta‐analysis

Association between Helicobacter pylori infection, eradication and diabetes mellitus

Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice

Contact Info

Product

Resources

About