Aqueous Humor Cytokine Levels as Biomarkers of Disease Severity in Diabetic Macular Edema

Hillier, Roxane J.; Ojaimi, Elvis; Wong, David T.; Mak, Michael; Berger, Alan R.; Kohly, Radha P.; Kertes, Peter J.; Forooghian, Farzin; Boyd, Shelley; Eng, Kenneth T.; Altomare, Filiberto; Giavedoni, Louis R.; Nisenbaum, Rosane; Muni, Rajeev H.

doi:10.1097/iae.0000000000001210

Cited by 66 publications

(69 citation statements)

References 19 publications

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“…According to previous studies,20 21 aqueous levels of some cytokines correlate with disease severity in DME, and hypoxia caused by fall in perfusion pressure in the retinal capillaries may be playing an important role in the development of DME 22. Recent study indicated that the size of hypoxic retina correlated significantly with aqueous VEGF levels 23.…”

Section: Discussionmentioning

confidence: 95%

Aqueous cytokine and growth factor levels indicate response to ranibizumab for diabetic macular oedema

et al. 2017

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Section: Discussionmentioning

confidence: 95%

Aqueous cytokine and growth factor levels indicate response to ranibizumab for diabetic macular oedema

et al. 2017

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“…Some of the most prevalent eye diseases such as glaucoma (Agnifili et al, 2015; Goyal et al, 2014), neovascular AMD (Kang et al, 2014; Liu et al, 2016; Park et al, 2014), diabetes-induced eye diseases (Hillier et al, 2016; Vujosevic et al, 2015, 2016), and uveitis (Haasnoot et al, 2016; Kalinina Ayuso et al, 2013), to name a few, have been investigated for biomarker content in the AH. Although the vast majority of nucleic acid and lipid biomarkers, and some of the protein biomarkers identified in AH were most likely exosome-associated, very little attention has been directed to the exosome-specific biomarkers.…”

Section: Exosome Biomarkers For Eye Diseasesmentioning

confidence: 99%

Roles of exosomes in the normal and diseased eye

Klingeborn

Dismuke

Rickman

et al. 2017

Progress in Retinal and Eye Research

137

127

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Exosomes are nanometer-sized vesicles that are released by cells in a controlled fashion and mediate a plethora of extra- and intercellular activities. Some key functions of exosomes include cell-cell communication, immune modulation, extracellular matrix turnover, stem cell division/differentiation, neovascularization and cellular waste removal. While much is known about their role in cancer, exosome function in the many specialized tissues of the eye is just beginning to undergo rigorous study. Here we review current knowledge of exosome function in the visual system in the context of larger bodies of data from other fields, in both health and disease. Additionally, we discuss recent advances in the exosome field including use of exosomes as a therapeutic vehicle, exosomes as a source of biomarkers for disease, plus current standards for isolation and validation of exosome populations. Finally, we use this foundational information about exosomes in the eye as a platform to identify areas of opportunity for future research studies.

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“…Leukostasis in DR is mainly caused by endothelial activation and increased surface expression of intercellular adhesion molecules (ICAM-1) [107]. Hillier et al stated that increases in ICAM-1 correlate with the severity of DR in patients [108]. Our study on ICAM-1 showed an increase of ICAM-1 expression in PDR patients with more than 10 years of diabetes history [103].…”

Section: Intercellular Adhesion Molecule-1mentioning

confidence: 64%

Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

Victor¹,

Sitompul²

2018

Early Events in Diabetic Retinopathy and Intervention Strategies

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This chapter discusses about the effect of vitreous immune system and biomarkers on the progression of proliferative diabetic retinopathy. Immune system and biomarkers have been believed to have an important role in the progression of diabetic retinopathy (DR) severity. Hyperglycemic will influence immune cells resulting in chronic inflammation on the retina. This condition progressively disrupts the blood-retinal barrier in retina causing those inflammatory molecules and immune cells to transfer from circulation. The transfer of these molecules plays an important part in the progression of proliferative diabetic retinopathy. In addition, biomarkers are indicators for some complex processes happened in our body, and are measured to determine diagnosis and prognosis of some treatment. There are several biomarkers that have been identified in DR patients including biomarkers of oxidative stress, hypoxia-inducible factors, angiogenic factors, pro-inflammatory cytokines, chemokines, cell adhesion molecules, and soluble CD200. The value of these biomarkers will tell us their possible role in the progression of DR. By improving the knowledge of molecular pathway in DR pathophysiology, the advancement of selective therapy approaches could be discovered and the management of DR could be more efficient.

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Aqueous Humor Cytokine Levels as Biomarkers of Disease Severity in Diabetic Macular Edema

Cited by 66 publications

References 19 publications

Aqueous cytokine and growth factor levels indicate response to ranibizumab for diabetic macular oedema

Aqueous cytokine and growth factor levels indicate response to ranibizumab for diabetic macular oedema

Roles of exosomes in the normal and diseased eye

Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

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