Maternal Prenatal Nutrition and Birth Outcomes on Malnutrition among 7- to 10-Year-Old Children: A 10-Year Follow-Up

Zhou, Jing; Zeng, Lingxia; Dang, Shaonong; Pei, Leilei; Gao, Wenlong; Li, Chao; Yan, Hong

doi:10.1016/j.jpeds.2016.06.017

Cited by 11 publications

(6 citation statements)

References 24 publications

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“…Previous studies identified age of children, sex of children, gestational weeks, economic status, prenatal micronutrients supplementation, birthweight and other social backgrounds as detrimentally affecting cognitive development of children 22 , 28 , 33 , 34 . In addition, the majority of variables mentioned above were also reported as being associated with physical growth of children in previous studies 35 – 37 . Therefore, we considered the following variables as potential confounders in the multivariate adjusted analysis: age of children, age of parents, sex of children, gestational weeks at birth, type of micronutrient supplement, household wealth index, older siblings of children, birthweight, educational level of parents, father’s occupation of parents, child school level.…”

Section: Measurementsmentioning

confidence: 76%

Effect of maternal pre-pregnancy underweight and average gestational weight gain on physical growth and intellectual development of early school-aged children

Zhu²,

Zeng

et al. 2018

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The aim of this study was to assess the effect of low maternal weight at pre-pregnancy and the average gestational weight gain on undernourished children and their intellectual development. From October 2012 to September 2013, we followed 1744 offspring of women who participated in a trial conducted from 2002 to 2006. Pregnant women recruited in the original trial could receive three prenatal health checks for free, at which maternal weight and height were measured. WISC-IV was used to estimate the intellectual development of children. Weight and height of both pregnant women and children were measured by trained anthropometrists using standard procedures. Having low maternal weight at pre-pregnancy was associated with an increased risk of undernutrition amongst children (underweight: OR = 2.02, 95%CI: 1.14–3.56, thinness: OR = 2.79, 95%CI: 1.50–5.17) and a decrease in verbal comprehension index (−2.70 points, 95%CI: −4.95–0.44) of children. The effect of average gestational weight gain on occurrences of underweight children (OR = 0.08, 95%CI: 0.01–0.55) was also found. We identified the effect of maternal pre-pregnancy underweight on impairment of the separate intellectual domains (verbal comprehension index) and increasing occurrence of undernourished children. Average gestational weight gain was positively associated with a decreased prevalence of underweight children but not with the intellectual development of children in rural China.

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Section: Measurementsmentioning

confidence: 76%

Effect of maternal pre-pregnancy underweight and average gestational weight gain on physical growth and intellectual development of early school-aged children

Zhu²,

Zeng

et al. 2018

Sci Rep

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“…Hb reduction during pregnancy is associated with small for gestational age (SGA) births, placental weight and placental ratio (10)(11)(12) . LBW babies are at higher risks of morbidity and mortality, and of adverse physical development in childhood, compared with normal birth weight babies (13,14) . Anaemia during pregnancy might have long-term adverse effects on younger children, and a study indicated that Fe-deficiency anaemia in the third trimester was associated with worse mental development of rural Chinese young children (15) .…”

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confidence: 99%

Multi-micronutrient supplementation during pregnancy for prevention of maternal anaemia and adverse birth outcomes in a high-altitude area: a prospective cohort study in rural Tibet of China

et al. 2017

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Anaemia during pregnancy, characterised by Hb <110 g/l, is a specific risk factor for adverse maternal and perinatal outcomes in developing countries. The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN) compared with folic acid (FA) on the occurrence of anaemia among pregnant women and their infants' health in a high-altitude area. A prospective cohort study was carried out in two rural counties in Tibet from 2007 to 2012. A total of 1149 eligible pregnant women were allocated daily supplementation with FA in one county and MMN containing a recommended allowance of twenty-three vitamins and minerals in another county starting ≤24 weeks of gestation and continuing until delivery. Compared with the FA group, prenatal supplementation with MMN was significantly associated with reduced odds of anaemia in the third trimester. This was demonstrated in the primary outcome, with an adjusted OR (AOR) of 0·63; 95 % CI 0·45, 0·88 and P=0·007 and also reduced odds of preterm delivery (AOR: 0·31; 95 % CI 0·15, 0·61; P=0·001). There was no difference between MMN and FA groups in mean birth weight (adjusted mean difference: 36·78; 95 % CI -19·42, 92·98 g; P=0·200), whereas MMN supplementation significantly reduced the odds of low-birth weight (LBW) babies (AOR: 0·58; 95 % CI 0·36, 0·91; P=0·019). In conclusion, the antenatal MMN supplementation in rural Tibet is associated with a reduction of maternal anaemia in the third trimester, and may potentially decrease the risk of preterm delivery and LBW babies.

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“…As early as the 1950s, protein malnutrition was identified as a key factor in global suffering [2], and-although focus on protein-specific malnutrition has waxed and waned over the following decades-recent studies show that protein-specific malnutrition continues to negatively impact human growth and development [3]. In pregnancy, maternal malnutrition has been associated with pre-term delivery, fetal growth restriction, and lifetime cardiac and endocrinologic consequences for the offspring [4][5][6]. With a high prevalence of protein-malnutrition in the developing world, important knowledge could be gained by understanding its effects on perinatal outcomes.…”

Section: Introductionmentioning

confidence: 99%

Micro-anatomic alterations of the placenta in a non-human primate model of gestational protein-restriction

et al. 2020

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Objectives Maternal protein malnutrition is associated with impaired fetal growth, and lifetime consequences for the offspring. Our group has previously developed a model of protein-restriction in the non-human primate, which was associated with fetal growth restriction, stillbirth, decreased placental perfusion, and evidence of fetal hypoxia, suggesting perturbed vascular development. Our objective was to histologically characterize the micro-anatomic alterations associated with adverse pregnancy outcomes taking an approach that permits investigation of the 3D vascular structure and surrounding histology without the requirement for 3D vascular casting or relying on 2D stereology which both have methodological limitations. Methods Rhesus macaques were assigned in the pre-gestational period to a control diet that contained 26% protein, or study diet containing 13% protein (50% PR diet). Placental tissue was collected at delivery and processed using a clarification, immunohistochemistry, and confocal microscopy protocol published previously by our group. Three dimensional reconstructions and quantitative assessment of the vascular micro-anatomy was performed using analysis software (Imaris ®) and statistical analysis accounted for maternal and fetal confounders. Results In unadjusted analysis, when comparing those pregnancies on a 50% PR diet (n = 4) with those on a control diet (n = 4), protein-restriction diet was associated with decreased maternal pre-pregnancy weight (difference of-1.975kg, 95% CI-3.267 to-0.6826). When controlling for maternal pre-pregnancy weight, fetal sex, and latency from tissue collection to

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Maternal Prenatal Nutrition and Birth Outcomes on Malnutrition among 7- to 10-Year-Old Children: A 10-Year Follow-Up

Cited by 11 publications

References 24 publications

Effect of maternal pre-pregnancy underweight and average gestational weight gain on physical growth and intellectual development of early school-aged children

Effect of maternal pre-pregnancy underweight and average gestational weight gain on physical growth and intellectual development of early school-aged children

Multi-micronutrient supplementation during pregnancy for prevention of maternal anaemia and adverse birth outcomes in a high-altitude area: a prospective cohort study in rural Tibet of China

Micro-anatomic alterations of the placenta in a non-human primate model of gestational protein-restriction

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