Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke

Tae, Barbara; Oliveira, Kelen Carneiro; Conceição, Rodrigo Rodrigues da; Valenti, Vítor Engrácia; Souza, Janaína Sena de; Laureano‐Melo, Roberto; Sato, Mônica Akemi; Maciel, Rui M. B.; Giannocco, Gisele

doi:10.1002/tox.22321

Cited by 11 publications

(5 citation statements)

References 69 publications

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“…Cygb has been implicated in oxygen transport, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation (Ou et al, 2018;Yassin et al, 2018). Consistent with its described functions, the expression of Cygb is upregulated in conditions associated with hypoxia, oxidative stress and inflammation (Guo et al, 2007;Tae et al, 2017;Yassin et al, 2018).…”

Section: Introductionmentioning

confidence: 79%

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Gomes

Sousa

Ott

et al. 2019

Front. Mol. Neurosci.

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Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation. This protein is expressed in brain areas including the preoptic area (POA) of the anterior hypothalamus, the region responsible for the regulation of body temperature. In this study, we show that Cygb is upregulated in the rat hypothalamus 2.5 h and 5 h after intravenous administration of lipopolysaccharide (LPS). We investigated the effect of treatment with Cygb in POA primary cultures stimulated with LPS for 4 h. The levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were measured and the results showed that Cygb reduced the concentrations of both cytokines. We further observed a decrease in immunoreactivity of the inflammatory transcription factor nuclear factor-κB (NF-κB), but not NF-IL6 and STAT3, in the nucleus of Cygb-treated POA cells. These findings suggest that Cygb attenuates the secretion of IL-6 and TNF-α in LPS-stimulated POA primary cultures via inhibition of the NF-κB signaling pathway, indicating that this protein might play an important role in the control of neuroinflammation and fever.

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Section: Introductionmentioning

confidence: 79%

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Gomes

Sousa

Ott

et al. 2019

Front. Mol. Neurosci.

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“…Passive smoking was significantly associated with wheezing, exercise wheezing, and asthma ever in the present study. The side stream of tobacco smoke, which comprises the main portion of passive smoking, is harmful to upper airway function and aggravates asthma by several mechanisms such as modulating antioxidant functions 19 . Passive smoking causes poor responses to steroids in asthma patients by increasing the leukotriene level and oxidative stress-related mechanisms, such as histone deacetylase-2 function via activation of the phosphoinositide-3-kinase/Akt pathway 20 , 21 .…”

Section: Discussionmentioning

confidence: 99%

Active and passive smoking impacts on asthma with quantitative and temporal relations: A Korean Community Health Survey

Kim

Sim

Choi

2018

Sci Rep

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This study aimed to evaluate the relations of smoking with asthma and asthma-related symptoms, considering quantitative and temporal influences. The 820,710 Korean adults in the Korean Community Health Survey in 2009, 2010, 2011, and 2013 were included and classified as non-smoker, past smoker or current smoker. Total smoking years, total pack-years, and age at smoking onset were assessed. Information on wheezing, exercise wheezing, and aggravation of asthma in the past 12 months and asthma diagnosis history and current treatment was collected. Multiple logistic regression analysis with complex sampling was used. Current and former smokers showed significant positive relations with wheezing, exercise wheezing, asthma ever, current asthma, and asthma aggravation. Current smokers demonstrated higher adjusted odd ratios (AORs) for wheezing, exercise wheezing, and asthma aggravation than former smokers. Former smokers showed higher AORs than current smokers for current asthma treatment. Longer passive smoking was related to wheezing and exercise wheezing. Greater age at smoking onset and duration since cessation were negatively related to wheezing, exercise wheezing, and current asthma; total pack-years demonstrated proportional associations with these symptoms. Former, current, and passive smoking was positively correlated with wheezing and exercise wheezing. Total pack-years and early initiation were increasingly related to asthma.

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“…The plausible pathophysiologic mechanisms of the effect of passive smoking on asthma might be comparable to those of active smoking. Although both active and passive smoking exposures are composed of comparable chemicals, side strem of cigarrete smoking is largely responsible for more hazardous side-effects of tobacco smoking 18 . The effects of passive smoking on asthma have been suggested to be additive to those of active smoking 10 .…”

Section: Discussionmentioning

confidence: 99%

Active, passive, and electronic cigarette smoking is associated with asthma in adolescents

Kim

Sim

Choi

2017

Sci Rep

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The present study investigated the associations of active, passive, and electronic cigarette (E-cigarette) smoking with asthma in Korean adolescents. We used the cross-sectional study of Korea Youth Risk Behavior Web-based Survey conducted in 2011, 2012 and 2013. Active smoking was classified into 4 groups (0 days, 1–5 days, 6–19 days, and ≥20 days a month). Passive smoking was also categorized into 4 groups (0 days, 1–2 days, 3–4 days, and ≥5 days a week). E-cigarette was defined as yes or no in the last 30 days. Age, sex, obesity, region of residence, economic level, and parental educational level were adjusted for as confounders. Smoking variables were adjusted for one another. Adjusted odd ratios (AORs) and 95% confidence intervals (CIs) were calculated using multiple logistic regression analysis with complex sampling. In total, 2.3% (4,890/216,056) of participants reported asthma in the past 12 months. Active smoking was significantly associated with asthma (AOR [95% CI] of smoking ≥20 days/month = 1.57 [1.38–1.77], P < 0.001). Passive smoking was also related with asthma (AOR [95% CI] of smoking ≥5 days/week = 1.40 [1.28–1.53], P < 0.001). E-cigarette showed positive relation with asthma, although the effects of past smoking history could not be excluded (AOR [95% CI] = 1.12 [1.01–1.26], P = 0.027).

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Evaluation of globins expression in brain, heart, and lung in rats exposed to side stream cigarette smoke

Cited by 11 publications

References 69 publications

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Active and passive smoking impacts on asthma with quantitative and temporal relations: A Korean Community Health Survey

Active, passive, and electronic cigarette smoking is associated with asthma in adolescents

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