Loss of microRNA Expression is Involved in the Development and Prognosis of Breast Cancer Complicated by Type 2 Diabetes Mellitus

Liu, Huan-Tao; Xu, Yuliang; Li, Huiying; Zhao, Jia; Zhai, Hao‐Ran; Chen, You

doi:10.5301/jbm.5000220

Cited by 10 publications

(7 citation statements)

References 26 publications

(26 reference statements)

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“…However, the pancreatic β-cell dysfunction usually progresses and results in insulin resistance and/or relative insulin insufficiency in key metabolic organs, such as skeletal muscle, liver and adipose tissues [3]. Long-term de-regulation of energy metabolism in T2DM leads to systemic complications, such as CAD (coronary artery disease), stroke, peripheral arterial disease [4], CKD (chronic kidney disease) [5], microvascular diseases (retinopathy) [6] and various other conditions, such as cancers [7,8,9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

Ding

Liang

et al. 2017

IJMS

107

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MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases. From 59 independent studies that met the inclusion criteria, we identified 158 dysregulated miRNAs in seven different major sample types. To understand the functional impact of these deregulated miRNAs, we performed targets prediction and pathway enrichment analysis. Results from our analysis suggested that the altered miRNAs are involved in the core processes associated with T2DM, such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This systematic survey of dysregulated miRNAs provides molecular insights on the effect of deregulated miRNAs in different tissues during the development of diabetes. Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM.

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Section: Introductionmentioning

confidence: 99%

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

Ding

Liang

et al. 2017

IJMS

107

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“…Recent studies have shown that tumor-derived micro RNAs can be detected in blood or serum [10] , thus opening a new biomarker discovery pathway. Therefore, miR-145 can be used as a novel biomarker because it can be easily detected in real-time quantitative RT-PCR [11] .…”

Section: Discussionmentioning

confidence: 99%

Microrna -145 Expression Inhibits Invasion and Metastasis of Cervical Cancer Cells

Zhou¹,

Liu²,

Lin³

2017

Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

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Abstract. [Purposes] To investigate the expression of microRNA-145 on invasion and metastasis of cervical cancer cells.[Methods] Analysis of the relationship between high expression of microRNA-145 on invasion and metastasis of cervical cancer cells by Transwell invasion assay and Wound scratch assay. [Results] There is a certain correlation between inhibit the invasion and metastasis and microRNA-145 high expression in cervical cancer cells (P<0.05).[Conclusions] MicroRNA-145 inhibiting cervical cancer invasion and metastasis in the occurrence and development of cervical cancer. Can be used for targeted therapy of cervical cancer and prognosis judgement index.

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“…Of the 15 articles, 4 animal experiment studies and 3 with incomplete data or incalculable data after contacting the authors to try get original data were excluded. Therefore, eight articles [7,[13][14][15][16][17][18][19] satisfying the inclusion criteria were presented in this meta-analysis. The specific retrieval process is shown in Figure 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The specific retrieval process is shown in Figure 1. Among the eight articles included in the present study, seven articles [7,[13][14][15][16][17][18] compared the expression of miR-145 in breast cancer tissue with that in paracancerous tissue or normal breast tissue, three articles [7,18,19] analyzed the relationship between miR-145 expression and histopathology, and two articles [13,19] discussed the relationship between miR-145 expression and clinical prognosis. The characteristics of the literature included in this meta-analysis are shown in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Heterogeneity detection, calculation model and pooled SMD of subgroup analysis are shown in Table 2. In addition, Liu et al and Thakur et al analyzed the relationship between the expression level of miR-145 in tumor tissues and tumor tissue grade [16,19]. Both studies suggested that a negative correlation between miR-145 expression and histological tumor grade.…”

Section: Figure 2 Random-effects Smd For the Association Of Mir-145 mentioning

confidence: 99%

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Meta-analysis of the clinicopathological significance of miRNA-145 in breast cancer

Zhang

Hou

et al. 2020

Bioscience Reports

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Low expression of tumor suppressor miRNA and high expression of carcinogenic miRNA promote the occurrence and progression of human cancer. Most studies show that miR-145 is a tumor suppressor miRNA, and is closely related to the clinicopathology of breast cancer. However, the results are still inconsistent. Therefore, we conducted a meta-analysis on the basis of eligible studies to summarize the possible correlation between miR-145 and the clinicopathology and prognosis of breast cancer. Using PubMed, EMBASE, Web of Science, WANFANG and CNKI, we searched all published papers written in either English or Chinese on miR-145 expression in breast cancer from 1990 to November 2019 for meta-analysis. We used standardized mean (SMD) to evaluate the differential expression of miR-145 in breast cancer tissues and adjacent normal tissues or normal breast tissues. We found that miR-145 expression was significantly lower in breast cancer tissues than that in adjacent normal tissues (SMD = -2.93, P<0.0001), and in healthy women (SMD = -0.52, P= 0.009). miR-145 expression was lower in breast cancer patients with ER-positive (SMD=0.65, P<0.001), HER-2-positive (SMD=-1.04, P<0.001), compared to their counterparts, respectively. In addition, breast cancer patients with low expression of miR-145 had larger tumor diameters (SMD=-1.97, P<0.001) and lymph node metastasis(SMD=-1.75, P<0.001) that are unfavorable prognostic factors. Conclusion: Low miR-145 is observed in breast cancer, which is closely related to molecular subtypes and unfavorable factors of breast cancer. The findings indicate that miR-145 is tumor suppressor miRNA, and may be a potential diagnostic and prognostic marker in breast cancer.

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Loss of microRNA Expression is Involved in the Development and Prognosis of Breast Cancer Complicated by Type 2 Diabetes Mellitus

Abstract: Loss of miR-145 expression is related to the development of breast cancer complicated by T2DM, and low miR-145 expression might be an adverse prognostic factor in patients with this disease.

Cited by 10 publications

References 26 publications

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus

Microrna -145 Expression Inhibits Invasion and Metastasis of Cervical Cancer Cells

Meta-analysis of the clinicopathological significance of miRNA-145 in breast cancer

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