Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Kasuga, Jun Ichi; Kawahara, Takashi; Takamoto, Daiji; Fukui, Sachi; Tokita, Takashi; Tadenuma, Tomoyuki; Narahara, Masaki; Fusayasu, Syusei; Terao, Hideyuki; Izumi, Kiyotaka; Ito, Hiroki; Hattori, Yusuke; Teranishi, Jun Ichi; Sasaki, Takeshi; Makiyama, Kazuhide; Miyoshi, Yasuhide; Yao, Masahiro; Yumura, Yasushi; Miyamoto, Hiroshi; Uemura, Hiroji

doi:10.1186/s12885-016-2443-6

Cited by 25 publications

(26 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, an elevated ratio of peripheral neutrophils-to-lymphocytes (NLR) has been recognized as a poor prognostic indicator in penile cancer, Patients with a high NLR had signi cantly worse CSS [17,18] and OS [16];Patients with a low LMR had signi cantly worse RFS and CSS than those with a high LMR [18].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Chen¹,

Li²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries. The major prognostic factors in PSCC are pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, which are hard to obtain precisely before the operation. Besides, micro-metastases will be detected in about 30% of intermediate-risk patients with clinically non-palpable inguinal lymph nodes after i nguinal lymph node dissection( ILND ) . It means approximately 70% of patients are unable to benefit from ILND who might suffered from the complications of surgery. We hope some biomarkers could be found which are able to predict the outcome before surgery and reflect the inguinal lymph nodes metastasis. Methods: A total of 349 consecutive patients of penile cancer in Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. The association between NLR,LMR,PLR,LDH and Overall survival(OS),progression free survival(PFS) , inguinal lymph node (N stage) was analyzed with K-M analysis, univariable, multivariable logistic regression and Kendall’s tau-b correlation coefficient. Results: Multivariate analysis reveal that only PLR was significant independent factor which is associated with inferior OS and PFS; Age and LDH was associated with inferior OS; Lymph node and metastatic status remained significant for OS and PFS as NCCN and EAU Guidelines indicated; the ages, tumor type, initial treatment and NLR LMR were not significant in predicting both OS and PFS. NLR, LMR and PLR were corresponded to N stage, while LDH was not associated with the N stage based on logistic regression model analysis. NLR, LMR and PLR were found weakly related to N stage through an application of Kendall’s tau-b correlation coefficient. Conclusions: PLR was significant independent factors for OS and PFS, Age and LDH was significant independent factors for OS. NLR, LMR, PLR was corresponded to N stage.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Chen¹,

Li²,

Zhang³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Recently, an elevated ratio of peripheral neutrophils-to-lymphocytes (NLR) has been recognized as a poor prognostic indicator in penile cancer, Patients with a high NLR had significantly worse CSS [17,18] and OS [16];Patients with a low LMR had significantly worse RFS and CSS than those with a high LMR [18].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of systemic inflammatory factors(NLR,LMR,PLR) and LDH in penile cancer

hu¹,

Li²,

Zhang³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Penile squamous cell carcinoma (PSCC)represents an important public health problem for developing countries, the major prognostic factors in PSCC are Pathological subtype, perineural invasion, lymphovascular invasion, depth of invasion and grade, these factors are hard to precisely obtain before the operation. Besides, intermediate-risk patients with clinically non-palpable inguinal lymph nodes , only about 30% of them are able to detect micro-metastases after ILND. That means the rest of patients approximately 70% have no benefit from ILND and suffered from the complications of surgery, so we hope to find some biomarkers that help us to predict the outcome before surgery and reflect the inguinal lymph nodes metastatic. Methods: A total of 349 consecutive patients of penile cancer at Yunnan cancer hospital in China between October 2002 and December2017. 225 was succeed to follow-up. According to the (AUROC) curve, we get the cut-off point, K-M analysis and multivariate logistic regression models and Bivariate correlations were used to detect the results. Results: Multivariate analysis reveal NLR, LMR, PLR was significant independent factors was associated with inferior OS; Only PLR was associated with inferior PFS; LDH was not associated with inferior OS and PFS. Anatomic stage and lymph node status remained significant for OS and PFS as NCCN and EAU Guidelines indicated；The tumor type and primary treatment was not significant for OS and PFS. In logistic regression analyses NLR, LMR, PLR was corresponded to N stage which divided into the Node-negative group and Node-positive groups, however the LDH was not associated with the N stage. However Kendall’s tau-b evaluated the correlations, NLR, LMR, PLR were weakly correlated to the N stage. Conclusions: NLR and LMR was significant independent factors for OS, PLR was significant independent factors both for OS and PFS. NLR, LMR, PLR was significant corresponded to N stage.

show abstract

“…Kasuga et al (2016) found that a higher baseline neutrophil to lymphocyte ratio was associated with increased disease specific mortality in patients with penile cancer. Interestingly, increased lymphocyte baseline count was associated with improved prognosis in multiple malignancies, including melanoma patients treated with pembrolizumab, an anti-programmed death (PD)-1 immunotherapeutic agent (Weide et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Prognostic and Predictive Factors in Patients with Advanced Penile Cancer Receiving Salvage (2nd or Later Line) Systemic Treatment: A Retrospective, Multi-Center Study

et al. 2016

View full text Add to dashboard Cite

Introduction and objectives: Metastatic penile squamous cell carcinoma (PSCC) is associated with dismal outcomes with median overall survival (OS) of 6–12 months in the first-line and <6 months in the salvage setting. Given the rarity of this disease, randomized trials are difficult. Prognostic risk models may assist in rational drug development by comparing observed outcomes in nonrandomized phase II studies and retrospective data vs. predicted outcomes based on baseline prognostic factors in the context of historically used agents. In this retrospective study, we constructed a prognostic model in the salvage setting of PSCC patients receiving second or later line systemic treatment, and also explored differences in outcomes based on type of treatment.Materials and methods: We performed a chart review to identify patients with locally advanced unresectable or metastatic PSCC who received second or later line systemic treatment in centers from North America and Europe. The primary outcome was OS from initiation of treatment, with secondary outcomes being progression-free survival (PFS) and response rate (RR). OS was estimated using the Kaplan-Meier method. Cox proportional hazards regression was used to identify prognostic factors for outcomes using univariable and multivariable models.Results: Sixty-five patients were eligible. Seventeen of 63 evaluable patients had a response (27.0%, 95% confidence interval [CI] = 16.6–39.7%) and median OS and PFS were 20 (95% CI = 20–21) and 12 (95% CI = 12, 16) weeks, respectively. Visceral metastasis (VM) and hemoglobin (Hb) ≤ 10 gm/dl were consistently significant poor prognostic factors for both OS and PFS, and Hb was also prognostic for response. The 28 patients with neither risk factor had a median OS (95% CI) of 24 (20–40) weeks and 1-year (95% CI) OS of 13.7% (4.4–42.7%), while the 37 patients with 1 or 2 risk factors had median OS (95% CI) of 20 (16–20) weeks and 1-year (95% CI) OS of 6.7% (1.8–24.9%). Cetuximab-including regimens were associated with a trend for improved RR compared to other agents (Odds ratio = 5.05, 95% CI = 0.84–30.37, p = 0.077). Taxanes vs. non-taxane, and combination vs. single agent therapy was not associated with improved outcomes. The study is limited by its modest sample size.Conclusion: This is the first prognostic classification proposed for patients receiving salvage systemic therapy for advanced PSCC. The presence of VM and Hb ≤ 10 gm/dl was associated with poor OS and PFS. Cetuximab appeared to be associated with better RR. This prognostic model may assist in salvage therapy drug development for this orphan disease by improving interpretation of outcomes seen in nonrandomized data.

show abstract

Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer

Cited by 25 publications

References 32 publications

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer

Prognostic Value of systemic inflammatory factors(NLR,LMR,PLR) and LDH in penile cancer

Prognostic and Predictive Factors in Patients with Advanced Penile Cancer Receiving Salvage (2nd or Later Line) Systemic Treatment: A Retrospective, Multi-Center Study

Contact Info

Product

Resources

About