Toxoplasmosis presenting with a subtle maculopapular eruption in a child post hematopoietic stem cell transplantation

Yang, Wei; Chen, Jiann Shiuh; Lee, Chaw Ning; Lee, Julia Yu Yun

doi:10.1016/j.jfma.2016.06.001

Cited by 5 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We used “ Toxoplasma gondii or Toxoplasmosis or Toxoplasma infection and children or pediatrics and hematopoietic stem cell transplantation” as the search term and retrieved the relevant literature from PubMed and summarized it, including 12 article s with 26 patients. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 European patients represented 46.2% (12/26) of the patients overall. Detailed information was provided in the literature for 18 patients aged 4–18 years.…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii infection in children after allogeneic hematopoietic stem cell transplantation: A case report and literature review

Luo

Shen

Chen

et al. 2021

Pediatric Investigation

View full text Add to dashboard Cite

Introduction Toxoplasmosis is a life‐threatening complication after hematopoietic stem cell transplantation (HSCT). However, for several reasons, clinicians know little about Toxoplasma infection. Case presentation We report a case of toxoplasmosis that was diagnosed by bone marrow smear and metagenomic next‐generation sequencing (mNGS) after HSCT in a boy. Additionally, we summarize the characteristics of toxoplasmosis after pediatric HSCT reported in the literature published in PubMed. Conclusion Clinicians should increase their awareness of toxoplasmosis in children after HSCT and implement pre‐transplant screening and post‐transplant monitoring and prevention in future according to the national conditions of our country.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii infection in children after allogeneic hematopoietic stem cell transplantation: A case report and literature review

Luo

Shen

Chen

et al. 2021

Pediatric Investigation

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…9 Toxoplasmosis after allo-and, to much less extent autologous, HCT and in patients with hematological malignancies has been described with variable manifestations including CNS infection characterized by multiple brain abscesses, but also presenting as meningoencophelitis and ventriculitis, pneumonia, cutaneous eruption, and disseminated infection. [10][11][12][13][14][15][16][17][18] In our institution, HLH following allo-HCT is relatively rare, with rates reported in the literature ranging 0.3-17%, with the highest incidence among CB recipients. 22,23 HLH is also associated with graft failure and poor outcomes including a mortality rate as high as 85%.…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis induced by Toxoplasma gondii infection diagnosed by a bone marrow biopsy and DNA next‐generation sequencing in an allogeneic hematopoietic stem cell transplant recipient

Obeid

Grzywacz

Ferrieri

et al. 2021

Transplant Infectious Dis

View full text Add to dashboard Cite

A 58-year-old female received a single umbilical cord blood (CB) unit transplantation with reduced intensity conditioning for FLT3+, NPM1+ AML in second complete remission. The preparative regimen consisted of cyclophosphamide, fludarabine, total body irradiation (TBI), and anti-thymocyte globulin (ATG). Tacrolimus and mycophenolate mofetil used for graft-versus-host disease prevention. Engraftment was achieved at day +20, as defined by an absolute neutrophil count >2.5 × 10 9 /L for 2 consecutive days. Standard antibacterial, antifungal, and antiviral prophylaxis included levofloxacin, micafungin during the conditioning period followed by voriconazole starting day +1, and high-dose acyclovir, respectively.Inhaled pentamidine starting on day +28 was substituted for trimethoprim/sulfamethoxazole (TMP/SMX) for Pneumocystis jirovecii pneumonia (PJP) prophylaxis to avoid myelosuppression.The hospital course (Figure 1) was complicated by febrile neutropenia on day +10 with findings of ground glass opacities on chest CT with non-revealing workup, which included negative blood and urine cultures, Aspergillus galactomannan (AG) and (1-3)β-d-glucan (BDG) and bronchoscopy with unremarkable bacterial and mycobacterial staining with no growth on bacterial-, fungal-, mycobacterial-,

show abstract

“…In humans, cutaneous toxoplasmosis is chiefly asymptomatic; yet, in acquired toxoplasmosis, lymphadenopathy might be present in association with papular rash, scattered prominent erythematous macules (3-4 mm), hard painful nodular lesions, or ulcers [123,124] . Lesions appear on the back, abdomen, shoulders, palms, and soles [125,126] . One study reported a case of toxoplasmosis in a febrile patient with skin manifestations [127] .…”

Section: Cutaneousmentioning

confidence: 99%

“…In a report, Yang et al [126] recommended early diagnosis and treatment of this fatal opportunistic parasite in order to improve prognosis. In another report, sulphadiazine and pyrimethamine failed to resolve the skin lesions and instead, the patient developed new lesions [125] .…”

Section: Cutaneousmentioning

confidence: 99%

Zoonotic parasites with significant importance for tropical dermatology

AO Elsaftawy,

Samanoudy,

M Wassef

et al. 2023

Parasitologists United Journal

View full text Add to dashboard Cite

Zoonotic arthropods Myiasis (myia, Greek word for "fly)The chief zoonotic potential occurs in humans through skin invasion by the developing larvae (maggots) of Diptera. Infested larvae feed on dead or living tissues of the skin [9] . The recorded prevalence of the disease relies only on published case reports. Myiasis is considered a differential diagnosis of skin diseases in tropical poor communities due to bad hygiene and poor housing conditions [10,11] . However, human myiasis may also occur in countries with enhanced hygiene, as reported from New York [12] , and in France [13] . Notably, in temperate countries, myiasis occurs in summer when fly breeding is at its maximum [14] . Predisposing factors involve skin cancers, diabetes, and vascular diseases [10,15] . Nosocomial infection with Sarcophaga larvae was recorded revealing the ability of maggots to reach to

show abstract

Toxoplasmosis presenting with a subtle maculopapular eruption in a child post hematopoietic stem cell transplantation

Cited by 5 publications

References 5 publications

Toxoplasma gondii infection in children after allogeneic hematopoietic stem cell transplantation: A case report and literature review

Toxoplasma gondii infection in children after allogeneic hematopoietic stem cell transplantation: A case report and literature review

Hemophagocytic lymphohistiocytosis induced by Toxoplasma gondii infection diagnosed by a bone marrow biopsy and DNA next‐generation sequencing in an allogeneic hematopoietic stem cell transplant recipient

Zoonotic parasites with significant importance for tropical dermatology

Contact Info

Product

Resources

About