Influence of piperine and quercetin on antidiabetic potential of curcumin

Kaur, Ginpreet; Invally, Mihir; Chintamaneni, Meena

doi:10.1515/jcim-2016-0016

Cited by 27 publications

(12 citation statements)

References 20 publications

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“…The co-administration of curcumin with a bioenhancer (piperine), to increase curcumin bioavailability, did not make curcumin any more efficient in regards to its antidiabetic and antioxidant effects [30]. Adding quercetin to orally administered curcumin can have a better effect on improving the glycemia and lipid profile in STZ-induced diabetes in rats [88]. TAC has shown no significant differences between study groups (with curcumin pre-treatment, Table 1, Figure 2), probably due to a different anti-oxidant system, as components of anti-oxidative status, that remained unchanged after these doses of i.p.…”

Section: Discussionmentioning

confidence: 99%

Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus

et al. 2019

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Curcumin (CC) is known to have anti-inflammatory and anti-oxidative properties and has already been tested for its efficiency in different diseases including diabetes mellitus (DM). New formulations and route administration were designed to obtain products with higher bioavailability. Our study aimed to test the effect of intraperitoneal (i.p.) administration of liposomal curcumin (lCC) as pre-treatment in streptozotocin(STZ)-induced DM in rats on oxidative stress, liver, and pancreatic functional parameters. Forty-two Wistar-Bratislava rats were randomly divided into six groups (seven animals/group): control (no diabetes), control-STZ (STZ-induced DM —60 mg/100g body weight a single dose intraperitoneal administration, and no CC pre-treatment), two groups with DM and CC pre-treatment (1mg/100g bw—STZ + CC1, 2 mg/100g bw—STZ + CC2), and two groups with DM and lCC pre-treatment (1 mg/100g bw—STZ + lCC1, 2 mg/100g bw—STZ + lCC1). Intraperitoneal administration of Curcumin in diabetic rats showed a significant reduction of nitric oxide, malondialdehyde, total oxidative stress, and catalase for both evaluated formulations (CC and lCC) compared to control group (p < 0.005), with higher efficacy of lCC formulation compared to CC solution (p < 0.002, excepting catalase for STZ + CC2vs. STZ + lCC1when p = 0.0845). The CC and lCC showed hepatoprotective and hypoglycemic effects, a decrease in oxidative stress and improvement in anti-oxidative capacity status against STZ-induced DM in rats (p < 0.002). The lCC also proved better efficacy on MMP-2, and -9 plasma levels as compared to CC (p < 0.003, excepting STZ + CC2 vs. STZ + lCC1 comparison with p = 0.0553). The lCC demonstrated significantly better efficacy as compared to curcumin solution on all serum levels of the investigated markers, sustaining its possible use as adjuvant therapy in DM.

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Section: Discussionmentioning

confidence: 99%

Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus

et al. 2019

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“…In this context, piperine promotes glucose uptake in skeletal muscles via ROS‐dependent activation of CAMMK/AMPK signaling pathway (Maeda et al, 2018). Treatment of diabetic rats with piperine caused a significant decrease in the concentration of blood sugar and increased insulin secretion (Kaur et al, 2016). It has also been reported that piperine and curcuminoids control the energy metabolism via modulation of adipokines in type 2 diabetes mellitus (Panahi et al, 2017).…”

Section: Health Perspectivesmentioning

confidence: 99%

Piperine: A review of its biological effects

Haq

Imran

Nadeem

et al. 2020

Phytotherapy Research

203

106

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Medicinal plants have been used for years as a source of food, spices, and, in traditional medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family Piperaceae is one of the most widely used spices all over the world. It has a distinct sharp flavor attributed to the presence of the phytochemical, piperine. Apart from its use as a spice, P. nigrum is frequently used for medicinal, preservation, and perfumery purposes. Black pepper contains 2–7.4% of piperine, varying in content is associated with the pepper plant. Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti‐obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials. Furthermore, piperine has also been documented for its hepatoprotective, anti‐allergic, anti‐inflammatory, and neuroprotective properties. This review highlights and discusses the medicinal and health‐promoting effects of piperine, along with possible mechanisms of its action in health promotion and disease prevention. In addition, the present review summarizes the recent literature related to piperine as a therapeutic agent against several diseases.

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“…From this observation, it can be stated that subeffective NF doses of bioactive compounds had no apparent effect on the antidiabetic parameters studied, while combined NF doses exhibited significant antidiabetic effects, possibly due to enhanced absorption of NFs in the circulation. Another reason for improved antidiabetic activity is the synergistic effect of two NFs, which ultimately enhanced pharmacological activity, as supported by the literature 9,10…”

Section: Discussionmentioning

confidence: 81%

“…A combination therapy of rutin and silymarin in streptozotocin (STZ)-induced diabetic rats for 6 weeks reduced plasma-glucose levels and significantly increased antioxidant activity in diabetic rats 9. Kaur et al10 reported the influence of piperine and quercetin on the antidiabetic potential of curcumin, and found that a combination of the three had significant therapeutic potential when compared with curcumin alone. Therefore, the combinational intake of these with foods or synergistic efficacy of these bioactive compounds will be a future research area in diabetic disease management.…”

Section: Introductionmentioning

confidence: 99%

<p>Antidiabetic activity enhancement in streptozotocin + nicotinamide–induced diabetic rats through combinational polymeric nanoformulation</p>

Rani

Dahiya

Dhingra

et al. 2019

IJN

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Background: The bioactive compounds glycyrrhizin (GL) and thymoquinone (TQ) have been reported for antidiabetic activity in pure and nanoformulation (NF) form. However, the antidiabetic effect of a combined nanoformulation of these two has not been reported in the literature. Here, a combinational nanomedicine approach was investigated to enhance the antidiabetic effects of the two bioactive compounds of GL and TQ (GT), in type 2 diabetic rats in reference to metformin. Methods: Two separately prepared NFs of GL (using polymeric nanoparticles) and TQ (using polymeric nanocapsules) were mixed to obtain a therapeutic cargo of nanomedicine and then characterized with respect to particle size, stability, morphology, chemical interaction, and in vivo behavior. Additionally, NFs were evaluated for their cytotoxic effect on Vero cell lines compared to the pure form. This nanomedicine was administered orally, both independently and in combination (pure form or NF) for 21 successive days to type 2 diabetic rats and the effect assessed in term of body weight, fasting blood-glucose level, and various biochemical parameters (such as lipid-profile parameters and HbA 1c ). Results: When these nanomedicines were applied in combined rather than individual forms, significant decreases in blood glucose and HbA 1c and significant improvements in body weight and lipid profile were observed, despite them containing lower amounts than the pure forms. The treatment of diabetic rats with GL and TQ, when administered independently in either pure or NF forms, did not lead to favorable trends in any studied parameters. Conclusion: The administration of combined GT NFs exhibited significant improvement in studied parameters. Improvements in antidiabetic activity could have been due to a synergistic effect of combined NFs, leading to enhanced absorption of NFs and lesser cytotoxic effects compared to pure bioactive compounds. Therefore, GT NFs demonstrated potential as a new medicinal agent for the management of diabetes.

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Influence of piperine and quercetin on antidiabetic potential of curcumin

Abstract: Treatment with combinatorial extract of curcumin presented a significantly better therapeutic potential when compared with curcumin alone, which reveals that CPQ, with reduced dose of curcumin may serve as a therapeutic agent in the treatment of type 2 diabetes mellitus.

Cited by 27 publications

References 20 publications

Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus

Liposomal Curcumin is Better than Curcumin to Alleviate Complications in Experimental Diabetic Mellitus

Piperine: A review of its biological effects

<p>Antidiabetic activity enhancement in streptozotocin + nicotinamide–induced diabetic rats through combinational polymeric nanoformulation</p>

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