Estimation of an image derived input function with MR-defined carotid arteries in FDG-PET human studies using a novel partial volume correction method

Erlandsson, Kjell; Law, Ian; Larsson, Henrik; Ourselin, Sébastien; Arridge, Simon; Atkinson, David; Hutton, Brian F.

doi:10.1177/0271678x16656197

Cited by 55 publications

(68 citation statements)

References 22 publications

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“…However in PET studies of the brain, calculation of the IDIF is challenged by two factors: PVE [231,232] due to the small size of the blood pools, and subject motion [232,233]. Various approaches have been proposed to extract an accurate IDIF that can be classified into PET-only based methods [232,[234][235][236][237][238][239][240][241][242][243][244], stand-alone PET and MR-based methods [228,245,246], and fully-integrated PET/MR-based methods [247][248][249]. Combined PET/MR can potentially allow researchers to address the aforementioned challenges (PVE and subject motion) in an automatic way [228,248,249], in addition to bearing a logistic advantage.…”

Section: Kinetic Modeling and Image Derived Input Function (Idif)mentioning

confidence: 99%

“…However, the TA varies significantly with the quality of the underlying image data, thus, limiting the reproducibility Here, C P represents the blood activity and C 1 , C 2 the activity concentration of each tissue over time t. K1, k2, etc., are the rate constants that define the rate of tracer movement between compartments. This figure was adapted from Sari et al [228], with permission of SAGE Publications, Ltd.…”

Section: Multi-parametric Imaging (Mpi)mentioning

confidence: 99%

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Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Kinetic Modeling and Image Derived Input Function (Idif)mentioning

confidence: 99%

Section: Multi-parametric Imaging (Mpi)mentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…To obviate the need for the arterial input function (AIF) in brain studies, several methodologies have been proposed to extract an image-derived input function (IDIF) directly from PET images (4)(5)(6)(7)(8)(9)(10)(11)(12). These studies demonstrated that the extraction of an IDIF from a dynamic PET dataset requires 3 main tasks: the accurate definition of a blood-pool region, the accurate correction for subject motion, and the exact correction of extracted time-activity curves for partial-volume effects because of the small diameter of the internal carotid arteries.…”

mentioning

confidence: 99%

“…In past implementations, an IDIF was extracted either from PET/CT data in conjunction with a separate MRI scan (4,6,10,12) or from a fully integrated PET/MRI protocol (7,8,11,13). In particular, taking advantage of methodologic advances provided by fully integrated PET/MRI allows the 3 challenges mentioned earlier to be addressed in a straightforward manner.…”

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confidence: 99%

Promise of Fully Integrated PET/MRI: Noninvasive Clinical Quantification of Cerebral Glucose Metabolism

et al. 2019

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We describe a fully automated processing pipeline to support the noninvasive absolute quantification of the cerebral metabolic rate for glucose (CMRGlc) in a clinical setting. This pipeline takes advantage of "anatometabolic" information associated with fully integrated PET/MRI. Methods: Ten healthy volunteers (5 men and /5 women; 27 ± 7 y old; 70 ± 10 kg) underwent a test-retest 18 F-FDG PET/MRI examination of the brain. The imaging protocol consisted of a 60-min PET list-mode acquisition with parallel MRI acquisitions, including 3-dimensional time-of-flight MR angiography, MRI navigators, and a T1-weighted MRI scan. State-of-the-art MRI-based attenuation correction was derived from T1-weighted MRI (pseudo-CT [pCT]). For validation purposes, a low-dose CT scan was also performed. Arterial blood samples were collected as the reference standard (arterial input function [AIF]). The developed pipeline allows the derivation of an image-derived input function (IDIF), which is subsequently used to create CMRGlc maps by means of a Patlak analysis. The pipeline also includes motion correction using the MRI navigator sequence as well as a novel partial-volume correction that accounts for background heterogeneity. Finally, CMRGlc maps are used to generate a normative database to facilitate the detection of metabolic abnormalities in future patient scans. To assess the performance of the developed pipeline, IDIFs extracted by both CT-based attenuation correction (CT-IDIF) and MRI-based attenuation correction (pCT-IDIF) were compared with the reference standard (AIF) using the absolute percentage difference between the areas under the curves as well as the absolute percentage difference in regional CMRGlc values. Results: The absolute percentage differences between the areas under the curves for CT-IDIF and pCT-IDIF were determined to be 1.4% ± 1.0% and 3.4% ± 2.6%, respectively. The absolute percentage difference in regional CMRGlc values based on CT-IDIF and pCT-IDIF differed by less than 6% from the reference values obtained from the AIF. Conclusion: By taking advantage of the capabilities of fully integrated PET/MRI, we developed a fully automated computational pipeline that allows the noninvasive determination of regional CMRGlc values in a clinical setting. This methodology might facilitate the proliferation of fully quantitative imaging into the clinical arena and, as a result, might contribute to improved diagnostic efficacy.

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“…With combined PET/MRI systems, it is possible to develop kinetic models that utilise both dynamic PET and dynamic MRI data for parameter estimation [105]. These systems can also be useful for non-invasive estimation of the input function, which is normally required for kinetic modelling [106].…”

Section: Accounting For Temporal Changesmentioning

confidence: 99%

Advances in clinical molecular imaging instrumentation

Hutton

Erlandsson

Thielemans

2018

Clin Transl Imaging

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In this article, we describe recent developments in the design of both single-photon emission computed tomography (SPECT) and positron emission tomography (PET) instrumentation that have led to the current range of superior performance instruments. The adoption of solid-state technology for either complete detectors [e.g., cadmium zinc telluride (CZT)] or read-out systems that replace photomultiplier tubes [avalanche photodiodes (APD) or silicon photomultipliers (SiPM)] provide the advantage of compact technology, enabling flexible system design. In SPECT, CZT is well suited to multi-radionuclide and kinetic studies. For PET, SiPM technology provides MR compatibility and superior time-of-flight resolution, resulting in improved signal-to-noise ratio. Similar SiPM technology has also been used in the construction of the first SPECT insert for clinical brain SPECT/MRI.

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Estimation of an image derived input function with MR-defined carotid arteries in FDG-PET human studies using a novel partial volume correction method

Cited by 55 publications

References 22 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

Promise of Fully Integrated PET/MRI: Noninvasive Clinical Quantification of Cerebral Glucose Metabolism

Advances in clinical molecular imaging instrumentation

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