Predictive performance of quick Sepsis-related Organ Failure Assessment for mortality and ICU admission in patients with infection at the ED

Wang, Junyu; Chen, Yun-Xia; Guo, Shubin; Xue, Mei; Yang, Peng

doi:10.1016/j.ajem.2016.06.015

Cited by 114 publications

(80 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…qSOFA scores expected to provide facilities associated with the complexity of the system. By minimizing the scoring system and use only the parameters that do not depend on the results of laboratory tests, the expected results of the assessment can be done more easily, quickly and interventions can be done early, so it can reduce the mortality rate in general [4]. This is supported by the results of studies that have been done before, that increased subvariable coagulation, renal, and hepatic did not provide significant correlation on mortality.…”

Section: Introductionsupporting

confidence: 74%

Comparative Validity Sequential Scoring System Organ Failure Assesment (SOFA) and Quick - Sequential Organ Failure Assesment (qSOFA) on Estimating Mortality for Patients Treated in the Intensive Care Unit of Sanglah General Hospital

Aryabiantara¹,

Wiryana²,

Sinardja³

et al. 2017

J Aging Sci

View full text Add to dashboard Cite

Objectives: The purpose of this study was to assess that qSOFA validity is equal with SOFA as the predictor of mortality, both in sepsis and nonsepsis patients.Design: Diagnostic test with a retrospective design. Setting:Intensive Care Unit in Sanglah General Hospital, Bali. Indonesia. Subjects:Patients admitted to the ICU Sanglah General Hospital, from July 2015 to December 2016 (n=192), that have complete data and able to be evaluated with SOFA score. Interventions: None Measurement and Main Results:With the total population sampling techniques, 192 patients have met the criteria as the samples. The descriptive statistical analysis were performed, and the area under the ROC curve (AuROC) were used. The cutoff points will also be determined and will conclude the sensitivity and specificity of each score. From the 192 patients, the cutoff point for the SOFA and qSOFA are 11 and 2. While the AuROC from SOFA and qSOFA are 0.9307 and 0.9241, with p=0.7037 (95% confidence interval). Conclusion:In this study, we conclude that the validity of qSOFA is equal to SOFA, both in sepsis and nonsepsis. So, for the reasons of efficiency and effectiveness, qSOFA can be used to replace SOFA score in predicting mortality in ICU.

show abstract

Section: Introductionsupporting

confidence: 74%

Comparative Validity Sequential Scoring System Organ Failure Assesment (SOFA) and Quick - Sequential Organ Failure Assesment (qSOFA) on Estimating Mortality for Patients Treated in the Intensive Care Unit of Sanglah General Hospital

Aryabiantara¹,

Wiryana²,

Sinardja³

et al. 2017

J Aging Sci

View full text Add to dashboard Cite

show abstract

“…Wang et al have shown that the AUC for qSOFA in predicting mortality was lower than those for APACHE II, SOFA, and MEDS scores, but only the difference between qSOFA and MEDS was statistically significant (14). In the present study, the AUCs of qSOFA and SOFA were significantly different; on the contrary, no difference was found between APACHE II and SIRS.…”

Section: Discussioncontrasting

confidence: 44%

A Study on Physicians Perspectives on Elder Abuse and Neglect

ERASLAN¹

2018

tjgeri

View full text Add to dashboard Cite

Introduction:In elderly patients with clinically diagnosed sepsis, we investigated the performance of quick sepsis-associated organ failure assessment in admission to the mortality and intensive care unit and compared its performance with acute physiology and chronic health assessment, assessing systemic inflammatory response syndrome, sepsis-related organ failure.Materials and Method: From February 2016 to February 2017, we retrospectively reviewed 92 elderly patients (≥65 years of age) who were clinically diagnosed with sepsis in the intensive care unit. We compared the performance of organ failure assessment associated with sepsis, acute physiology and chronic health assessment II, systemic inflammatory response syndrome, and quick sepsis related with organ failure assessment, foreseeing a 28-day mortality in the intensive care unit.Results: The scores of organ failure assessment associated with quick sepsis were 1 in 6.5% (n=6), 2 in 30.4% (n=28) and 3 in 63% (n=58) Mean sepsis-related organ failure rating score was 9.2±3.0, mean systemic inflammatory response syndrome score was 2.6±0.6, and acute physiology and chronic health assessment score II was 25.4±7.2. There was a statistically significant difference (p<0.001) between patients with mortality rates of> 7 and <7 and 81% and 31% respectively in patients with organ failure assessment score associated with sepsis.Conclusion: Quick sepsis related organ failure assessment may be a better alternative in determining mortality risk, since it can be easily applied when compared to sepsis related organ failure assessment in geriatric patients.Keywords: Organ dysfunction scores; Sepsis; Geriatrics; Critical careGiriş: Klinik olarak tanısı konmuş sepsis olan yaşlı hastalarda mortalite ve yoğun bakım ünitesine kabul etmede hızlı sepsis ile ilişkili organ yetmezliği değerlendirmesinin performansını araştırdık ve performansını sistemik inflamatuar yanıt sendromu, sepsis ile ilişkili organ yetmezliği değerlendirmesi ve akut fizyoloji ve kronik sağlık değerlendirmesi ile karşılaştırdık.Gereç ve Yöntem: Şubat 2016'dan Şubat 2017'ye kadar, yoğun bakım ünitesinde klinik olarak sepsis tanısı alan 92 yaşlı (≥65 yaş) hastayı retrospektif olarak inceledik. Yoğun bakım ünitesinde 28 günlük mortaliteyi öngörmede sepsis ile ilişkili organ yetmezliği değerlendirmesi, akut fizyoloji ve kronik sağlık değerlendirmesi II, sistemik inflamatuar yanıt sendromu ve hızlı sepsis ile ilişkili organ yetmezliği değerlendirmesinin performansını karşılaştırdık.Bulgular: Hızlı sepsis ile ilişkili organ yetmezliği değerlendirmesi skorları %6.5 (n=6) hastada 1, %30.4 (n=28) hastada 2 ve %63 (n=58) hastada 3 idi. Ortalama sepsis ile ilişkili organ yetmezliği değerlendirmesi skoru 9.2±3.0, ortalama sistemik inflamatuar yanıt sendromu skoru 2.6±0.6 ve akut fizyoloji ve kronik sağlık değerlendirmesi II skoru 25.4±7.2 idi. Ölüm oranları >7 and <7 sepsis ile ilişkili organ yetmezliği değerlendirmesi skoru olan hastalarda sırasıyla %81 ve %31 olup, aralarında istatistiksel olarak anlamlı bir fark bulunmu...

show abstract

“…Discrimination of mortality using qSOFA was also lower than the Mortality in Emergency Department Sepsis (MEDS) score according to another retrospective study [18]. The latter study by Wang and colleagues did not compare qSOFA with SIRS score [18]. Thus, our report may contribute to the accumulating evidence on the potential clinical usefulness of qSOFA.…”

Section: Discussionmentioning

confidence: 60%

“…However, accuracy of qSOFA was worse than that of general early warning scores, such as the Modified Early Warning Score and the National Warning Score [17]. Discrimination of mortality using qSOFA was also lower than the Mortality in Emergency Department Sepsis (MEDS) score according to another retrospective study [18]. The latter study by Wang and colleagues did not compare qSOFA with SIRS score [18].…”

Section: Discussionmentioning

confidence: 99%

Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

et al. 2017

View full text Add to dashboard Cite

BackgroundThe Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) for identification of patients at risk of sepsis outside the intensive care unit (ICU). We attempted to compare the discriminatory capacity of the qSOFA versus the Systemic Inflammatory Response Syndrome (SIRS) score for predicting mortality, ICU-free days, and organ dysfunction-free days in patients with suspicion of infection outside the ICU.MethodsThe Weill Cornell Medicine Registry and Biobank of Critically Ill Patients is an ongoing cohort of critically ill patients, for whom biological samples and clinical information (including vital signs before and during ICU hospitalization) are prospectively collected. Using such information, qSOFA and SIRS scores outside the ICU (specifically, within 8 hours before ICU admission) were calculated. This study population was therefore comprised of patients in the emergency department or the hospital wards who had suspected infection, were subsequently admitted to the medical ICU and were included in the Registry and Biobank.ResultsOne hundred fifty-two patients (67% from the emergency department) were included in this study. Sixty-seven percent had positive cultures and 19% died in the hospital. Discrimination of in-hospital mortality using qSOFA [area under the receiver operating characteristic curve (AUC), 0.74; 95% confidence intervals (CI), 0.66–0.81] was significantly greater compared with SIRS criteria (AUC, 0.59; 95% CI, 0.51–0.67; p = 0.03). The qSOFA performed better than SIRS regarding discrimination for ICU-free days (p = 0.04), but not for ventilator-free days (p = 0.19), any organ dysfunction-free days (p = 0.13), or renal dysfunction-free days (p = 0.17).ConclusionsIn patients with suspected infection who eventually required admission to the ICU, qSOFA calculated before their ICU admission had greater accuracy than SIRS for predicting mortality and ICU-free days. However, it may be less clear whether qSOFA is also better than SIRS criteria for predicting ventilator free-days and organ dysfunction-free days. These findings may help clinicians gain further insight into the usefulness of qSOFA.Electronic supplementary materialThe online version of this article (doi:10.1186/s13054-017-1658-5) contains supplementary material, which is available to authorized users.

show abstract

Predictive performance of quick Sepsis-related Organ Failure Assessment for mortality and ICU admission in patients with infection at the ED

Cited by 114 publications

References 12 publications

Comparative Validity Sequential Scoring System Organ Failure Assesment (SOFA) and Quick - Sequential Organ Failure Assesment (qSOFA) on Estimating Mortality for Patients Treated in the Intensive Care Unit of Sanglah General Hospital

Comparative Validity Sequential Scoring System Organ Failure Assesment (SOFA) and Quick - Sequential Organ Failure Assesment (qSOFA) on Estimating Mortality for Patients Treated in the Intensive Care Unit of Sanglah General Hospital

A Study on Physicians Perspectives on Elder Abuse and Neglect

Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

Contact Info

Product

Resources

About