Die Bedeutung neurologischer, psychiatrischer und Suchterkrankungen für den Schwangerschaftsausgang: Fall-Kontroll-Studie der Geburtsjahrgänge 2010–2012

Grünwald, Leonard; Jorch, Gerhard; Kropf, Siegfried; Seeger, S; Seliger, G; Rißmann, Anke

doi:10.1055/s-0042-101870

Cited by 2 publications

(8 citation statements)

References 22 publications

(25 reference statements)

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“…The prevalence of epilepsy in the study collective (0.8%) was similar to that in a German study from 2016 11 . An American study also showed similar epilepsy prevalence (0.3 – 0.5%) 15 .…”

Section: Discussionsupporting

confidence: 85%

“…The meta-analysis by Ross et al provides contrasting results: children whose mothers had depression were significantly lighter and had lower Apgar scores than children of mothers without medically treated neuropsychiatric illness 27 . Other studies have also shown that newborns of women with neuropsychiatric illness are at increased risk of low birth weight 11 , 34 . This difference can also be explained by the greater proportion of control group women in this study without medication than with medication, since according to study data neuropsychiatric medication in particular can result in low birth weight 35 , 36 .…”

Section: Discussionmentioning

confidence: 97%

“…According to data from the American “National Survey on Drug Use and Health (NSDUH)” from 2012 the prevalence of illegal drug use during pregnancy was 5.9% among American women 6 . Data from central Germany show a prevalence of substance abuse among pregnant women of only 0.7% 11 . In our single-centre cohort the prevalence of substance abuse was comparable at 0.5%.…”

Section: Discussionmentioning

confidence: 99%

“…However, apart from one study by Grunwald et al there are no valid data available on pregnancy outcomes among mentally ill women in Germany 11 . The aim of this study was to describe the differences in pregnancy outcomes between women with neuropsychiatric illness or substance addiction (with and without medication) compared to mentally healthy women in a cohort from central Germany, and to define possible consequences for routine clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…Bisher gibt es jedoch, abgesehen von einer Studie von Grunwald et al, keine validen Daten über den Schwangerschaftsausgang mental erkrankter Frauen in Deutschland 11 . Ziel dieser Studie ist es, Unterschiede im Schwangerschaftsausgang bei von neuropsychiatrischer Erkrankung oder stoffgebundener Suchterkrankung betroffener Frauen (mit und ohne Medikation) im Vergleich zu psychisch gesunden Frauen in einer mitteldeutschen Kohorte aufzuzeigen und mögliche Konsequenzen für den klinischen Alltag darzulegen.…”

Section: Introductionunclassified

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Pregnancy Outcomes in Maternal Neuropsychiatric Illness and Substance Abuse

Bartel

Costa

Kropf

et al. 2017

Geburtshilfe Frauenheilkd

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Introduction Worldwide the prevalence of neuropsychiatric illness among women of reproductive age is higher than ever before. This study investigates the influences of maternal substance abuse/dependence and neuropsychiatric illness on pregnancy and neonatal outcomes. Patients and Methods Using a retrospective study design 185 pregnancies in women with neuropsychiatric illnesses or substance abuse were identified at a single centre over a period of 3.25 years and compared to 4907 pregnancies in healthy women without mental illness. Differences in pre-, peri- and postnatal pregnancy parameters were studied. Results Numbers of previous abortions on obstetric history were significantly higher in cases compared to controls, women with depression being especially affected. The number of antenatal visits was also higher among cases, especially in women with depression. The caesarean section rate was significantly higher in cases compared to controls. Children of women with neuropsychiatric illness were born at lower gestational ages than those of healthy control mothers, however there were no significant differences between case and control groups for birth weight, head circumference or Apgar scores. Some isolated differences were found for disease-specific case subgroups compared to controls. Conclusion The study shows a relationship between maternal neuropsychiatric illness and pregnancy outcomes independent of medication use. Rates of spontaneous abortion were higher. Children were born earlier, yet the neonatal outcomes birth weight, head circumference and Apgar score were not worse than children of mentally healthy women.

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Section: Discussionsupporting

confidence: 85%