“…The use of substances during pregnancy may increase the risk of mortality, premature birth, low birth weight, nervous system damage or delayed mental development (Ali et al, 2016;Gunn et al, 2016;Oei et al, 2012;Wolfe et al, 2005). Previous small and cross-sectional research described 1.3-4.3 times elevated risks of infant mortality (Fang et al, 2018;Good et al, 2010;Saleh Gargari et al, 2012;Wolfe et al, 2005) and an up to sixfold increased risk of low birth weight, preterm birth or microcephaly (Kivisto et al, 2015;Minozzi et al, 2020;Noland et al, 2005;Sudekum et al, 2019) comparing substance (including methamphetamine, opioid, heroin, methadone or alcohol)exposed pregnant mothers to unexposed ones. Past studies on substance-related topics have mostly focused on characteristics or health risks among substance users (Hser et al, 2012).…”