Primary Poorly Differentiated Squamous Cell Carcinoma of the Extrahepatic Bile Duct

Abstract

Squamous cell carcinoma of the extrahepatic bile duct is quite rare. A 77-year-old woman with jaundice and general fatigue was referred to our hospital. Multiphase contrast-enhanced computed tomography visualized a 17-mm solid mass in the junction of the cystic and common bile ducts. The patient underwent pylorus-preserving pancreaticoduodenectomy. The pathological findings demonstrated keratin-positive poorly differentiated squamous cell carcinoma of the extrahepatic bile duct (T3N0M0, stage IIIA). Although adjuvant chemotherapy with gemcitabine was administered, the patient exhibited local recurrence at the site of anastomosis of biliojejunostomy 20 months after resection and died 32 months after resection.

Primary Squamous Cell Carcinoma of the Common Bile Duct With Liver Metastases

“…Being associated withe liver metastasis, SCC of bile duct is even more rare. To our knowledge, this is the sixth case documented in the literature 3 .…”

“…Our case is so interesting because of its rarity. It is the sixth case documented of SCC of the extrahepatic CBD associated with liver metastasis 3 . Indeed, biliary cancers represent 3% of digestive cancers 4 .…”

“…Most of the tumors are diagnosed as adenocarcinomas 1 , whereas squamous cell carcinoma (SCC) are quite rare. Since the first case which was reported by Cabot and Painter 2 ,only 35 cases of bile duct SCC have beenreported in the literature 3 . Being associated withe liver metastasis, SCC of bile duct is even more rare.…”

Primary congenital choledochal cyst with squamous cell carcinoma: a case report

“… 4 However, primary squamous cell carcinoma of the extrahepatic bile duct is rare, and only 2% of biliary carcinomas are of squamous cell origin, 5 with only a few cases reported in approximately 100 years. 6 – 8 …”

Squamous cell carcinoma of the extrahepatic bile duct with metachronous para-aortic lymph node metastasis successfully treated with S-1 plus cisplatin

“…Yamana et al 13 reported a case of SCC of the perihilar bile duct treated with chemotherapy (first line: 5-fluorouracil (5-FU) plus cisplatin (FP), second line: gemcitabine plus S-1) because of recurrence in the liver 6 months after surgery, who died 12 months after surgery. Goto et al 15 reported a case of SCC of the perihilar bile duct treated with eight courses of gemcitabine as adjuvant chemotherapy, following with four courses (stopped due to progression of dementia) of gemcitabine because of local recurrence, who died 32 months after surgery. Other cases included regimens of cyclophosphamide plus doxorubicin plus methotrexate plus procarbazine,4 and one case had no description about the regimen 12.…”