Mentha longifolia protects against acetic-acid induced colitis in rats

Murad, Hussam; Abdallah, Hossam M.; Ali, Soad Shaker

doi:10.1016/j.jep.2016.06.016

Cited by 41 publications

(29 citation statements)

References 40 publications

(39 reference statements)

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“…Although the precise etiology of IBD remains unknown [1] , it is mainly caused by ulcerative colitis and Crohn's disease [2] . Crohn's disease causes inflammation that extends through the entire bowel wall, whereas ulcerative colitis affects the colon and/or the large intestine [3] . Geniposide (Figure 1), an iridoid glycosides purified from the fruit of Gardenia jasminoides Ellis, is known to have antiinflammatory, anti-oxidative and anti-tumor effects [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function

et al. 2017

Acta Pharmacol Sin

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Geniposide is an iridoid glycosides purified from the fruit of Gardenia jasminoides Ellis, which is known to have antiinflammatory, antioxidative and anti-tumor activities. The present study aimed to investigate the effects of geniposide on experimental rat colitis and to reveal the related mechanisms. Experimental rat colitis was induced by rectal administration of a TNBS solution. The rats were treated with geniposide (25, 50 mg·kg, ig) or with sulfasalazine (SASP, 100 mg·kg, ig) as positive control for 14 consecutive days. A Caco-2 cell monolayer exposed to lipopolysaccharides (LPS) was used as an epithelial barrier dysfunction model. Transepithelial electrical resistance (TER) was measured to evaluate intestinal barrier function. In rats with TNBS-induced colitis, administration of geniposide or SASP significantly increased the TNBS-decreased body weight and ameliorated TNBS-induced experimental colitis and related symptoms. Geniposide or SASP suppressed inflammatory cytokine (TNF-α, IL-1β, and IL-6) release and neutrophil infiltration (myeloperoxidase activity) in the colon. In Caco-2 cells, geniposide (25-100 μg/mL) ameliorated LPS-induced endothelial barrier dysfunction via dose-dependently increasing transepithelial electrical resistance (TER). The results from both in vivo and in vitro studies revealed that geniposide down-regulated NF-κB, COX-2, iNOS and MLCK protein expression, up-regulated the expression of tight junction proteins (occludin and ZO-1), and facilitated AMPK phosphorylation. Both AMPK siRNA transfection and AMPK overexpression abrogated the geniposide-reduced MLCK protein expression, suggesting that geniposide ameliorated barrier dysfunction via AMPKmediated inhibition of the MLCK pathway. In conclusion, geniposide ameliorated TNBS-induced experimental rat colitis by both reducing inflammation and modulating the disrupted epithelial barrier function via activating the AMPK signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function

et al. 2017

Acta Pharmacol Sin

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“…Finally, the reported antioxidant activities of M. longifolia (Murad et al, ) could be one of the possible ways by which it alleviates experimentally induced angina. The oxidative stress plays a very important role in the cardiac injury after ischemia‐reperfusion (Yamamoto, Nishimori, Fukutomi, Yamaguchi, & Orihashi, ).…”

Section: Discussionmentioning

confidence: 99%

“…Six-week-old male Wistar rats (King Abdulaziz University) were randomly divided into three experimental groups (8 animals M. longifolia extract was suspended in deionized water and administered daily by oral gavage in a dose of 200 mg/kg for three days before induction of angina. The dose 200 mg/kg for three days was selected as the smallest but effective dose of M. longifolia found in previous work from our laboratory on the same extract (Murad, Abdallah, & Ali, 2016). The two other groups received the vehicle.…”

Section: Study Protocolmentioning

confidence: 99%

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

2018

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Angina occurs due to imbalance between heart oxygen demand and supply and is associated with serious morbidity and mortality. Here, the possible antianginal effect of Mentha longifolia extract was studied in experimental model of angina. Aerial parts of M. longifolia were extracted, standardized, and given to rats three days before angina. Heart hemodynamics and conductivity were recorded by microtip catheter and surface electrodes. M. longifolia extract significantly alleviated the sustained decline in cardiac contractility after vasopressin exposure. However, M. longifolia did not affect the impaired cardiac dilation after vasopressin. Heart rate was significantly decreased after vasopressin exposure in rats treated with M. longifolia compared with untreated animals. In addition, M. longifolia produced more increase in systolic and diastolic durations after vasopressin exposure compared with untreated animals. Moreover, the plant extract alleviated the ST height changes during vasopressin injection. M. longifolia extract alleviates impaired cardiac function associated with angina through decreasing heart work. Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of angina. M. longifolia alleviated the impaired cardiac contractility associated with angina exposure. The antianginal effect of M. longifolia could be through reducing cardiac load. This can be concluded from the decrease in heart rate and the systolic and diastolic cycles elongation after exposure to vasopressin in animals pretreated with M. longifolia. This helps in reducing the associated cardiac ischemia upon exposure to vasopressin as indicated by ST change. This could provide new directions in the management of the serious angina disease.

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“…Plant diversity is an essential and rich source of pharmaceutically active chemical compounds [1][2][3][4][5][6]. Foodborne diseases present serious health risk worldwide.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antibacterial and antifungal activities of Saudi Arabian Mentha longifolia L. essential oil

Desam¹,

Al-Rajab²,

Sharma³

et al. 2017

JCLM

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Mentha longifolia protects against acetic-acid induced colitis in rats

Cited by 41 publications

References 40 publications

Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function

Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

Chemical composition, antibacterial and antifungal activities of Saudi Arabian Mentha longifolia L. essential oil

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