Mould and grass pollen allergy as risk factors for childhood asthma in Zaragoza, Spain

Segura, Nieves; Saldaña, José Luis Cubero; Sobrevía, M.T.; Lezaún, A.; Ferrer, Laia; Sebastian, Aleksandra; Colás, Carlos

doi:10.1016/j.aller.2016.02.003

Cited by 7 publications

(8 citation statements)

References 23 publications

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“…[22] The following were predictors of asthma: presence of rhinitis and/or eczema, positive prick test for certain aeroallergens, especially Alternaria and grass pollen, and family history of asthma. [23]…”

Section: Discussionmentioning

confidence: 99%

Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters

et al. 2018

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Background:Fungi as a source of allergen are still largely neglected in basic research as well as in clinical practice. This study aimed to highlight the impact of fungal allergens in a group of patients suffering from atopic dermatitis (AD).Aims and Objectives:The evaluation of the sensitization to fungi in AD patients aged 14 year and older and the evaluation of the relation of fungal sensitization to the occurrence of other atopic diseases and parameters.Materials and Methods:All patients satisfying inclusion criteria attending our hospital between 2008 and 2017 were included in the study. The complete dermatological and allergological examinations were performed in all included patients including examination of specific immunoglobulin E, skin prick test to mixture of fungi and inhalant allergens, evaluation of asthma bronchiale, rhinitis, onset of AD, family history about atopy, duration of eczematous lesions, severity of AD. Pairs of these categories were entered in the contingency tables and the Chi-square test for relationship of these variables was performed with the level of significance set below 5%.Results:Three hundred and thirty-one patients were included in the study; the average age was 26.8 years. The sensitization to fungi was recorded in 100 patients (30%). In these patients, the occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher than in patients without sensitization to fungi. We did not find any significant relation between the sensitization to fungi and the severity of AD, no relation was also found between the sensitization to fungi and sensitization to mites, animal dander, bird feather, and dust.Conclusion:The occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher in AD patients with sensitization to fungi. No relation was found between the severity of AD and the sensitization to fungi.

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Section: Discussionmentioning

confidence: 99%

Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters

et al. 2018

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“…Using improved culture techniques, numerous common environmental fungi are readily identified from spontaneously produced human sputa [4,[19][20][21] and these fungi all have the potential to induce airway mycosis and asthma-like allergic airway disease in mice [1,22]. These observations together with extensive epidemiologic [23][24][25][26], hypersensitivity [27][28][29][30][31][32][33], antifungal clinical trial [34,35], and other studies [5,[36][37][38][39][40][41] support the relatively recent recognition that airway mycosis underlies severe, treatment-refractory forms of asthma [2]. However, in addition to fungal spores, humans routinely inhale other pro-inflammatory environmental agents such as LPS.…”

Section: Discussionmentioning

confidence: 99%

Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide

et al. 2021

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Background Inhalation of fungal spores is a strong risk factor for severe asthma and experimentally leads to development of airway mycosis and asthma-like disease in mice. However, in addition to fungal spores, humans are simultaneously exposed to other inflammatory agents such as lipopolysaccharide (LPS), with uncertain relevance to disease expression. To determine how high dose inhalation of LPS influences the expression of allergic airway disease induced by the allergenic mold Aspergillus niger (A. niger). Methods C57BL/6J mice were intranasally challenged with the viable spores of A. niger with and without 1 μg of LPS over two weeks. Changes in airway hyperreactivity, airway and lung inflammatory cell recruitment, antigen-specific immunoglobulins, and histopathology were determined. Results In comparison to mice challenged only with A. niger, addition of LPS (1 μg) to A. niger abrogated airway hyperresponsiveness and strongly attenuated airway eosinophilia, PAS+ goblet cells and TH2 responses while enhancing TH1 and TH17 cell recruitment to lung. Addition of LPS resulted in more severe, diffuse lung inflammation with scattered, loosely-formed parenchymal granulomas, but failed to alter fungus-induced IgE and IgG antibodies. Conclusions In contrast to the strongly allergic lung phenotype induced by fungal spores alone, addition of a relatively high dose of LPS abrogates asthma-like features, replacing them with a phenotype more consistent with acute hypersensitivity pneumonitis (HP). These findings extend the already established link between airway mycosis and asthma to HP and describe a robust model for further dissecting the pathophysiology of HP.

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“…Jariwala et al performed the study to better understand the contribution of pollen and fungi to asthma severity in Bronx. According to their results, there exists a significant association between spring asthma bronchiale and tree pollen concentrations in a highly urbanised area such as Bronx (Jariwala et al, 2014;Segura et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

Čelakovská

Bukač

Vaňková

et al. 2019

Food and Agricultural Immunology

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The aim of this study is the evaluation of the sensitisation to molecular allergens of Alternaria alternata, Aspergillus fumigatus and Cladosporium herbarum in atopic dermatitis patients. The complete dermatological and allergological examination including the examination of the sensitisation to molecular allergens with Multiplex ISAC testing was performed in all included patients. The statistical evaluation of the relation between the sensitisation to Alt a 1, Alt a 6, Cla h 8, Asp f 1, Asp f 3, Asp f 6 and other molecular food and inhalant allergens was performed. The sensitisation to molecular fungal allergen was recorded altogether in 58% patients; it is in significant relation to the sensitisation to some food and inhallant molecular allergens, such as Peanut,

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Mould and grass pollen allergy as risk factors for childhood asthma in Zaragoza, Spain

Abstract: The following are predictors of asthma: History of hospital admissions for lower respiratory tract illness, presence of rhinitis and/or eczema, positive prick test for certain aeroallergens, especially Alternaria and grass pollen, and family history of asthma.

Cited by 7 publications

References 23 publications

Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters

Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters

Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide

Sensitisation to molecular allergens of Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus in atopic dermatitis patients

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