Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome

Patel, Amy; Hasak, Stephen; Cassell, Benjamin; Ciorba, Matthew A.; Vivio, Emily; Kumar, Mrudula; Gyawali, C. Prakash; Sayuk, Gregory S.

doi:10.1111/apt.13677

Cited by 70 publications

(76 citation statements)

References 58 publications

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“…These scores suggest impairment in everyday activities, mood, and personal relationships. These findings are consistent with results in similar studies (Drossman et al, 2007;Monnikes, 2011;Patel et al, 2016) noting significant impairment of HRQOL for patients with IBS. Unique to the current study, HRQOL levels were more greatly impaired than previous reports and significantly associated to catastrophizing coping style.…”

Section: Discussionsupporting

confidence: 92%

Effect of Illness Representations and Catastrophizing on Quality of Life in Adults With Irritable Bowel Syndrome

Sherwin¹,

Leary²,

Henderson³

2016

J Psychosoc Nurs Ment Health Serv

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There is limited understanding of the influence of psychosocial factors on irritable bowel syndrome (IBS), which contributes to management difficulties and ineffective long-term treatment. The goal of the current study was to assess the effect illness representations and coping had on health-related quality of life (HRQOL) in adults with IBS. Self-report data were collected from 101 adults with IBS. Illness representations were measured with the Revised Illness Perception Questionnaire; catastrophizing was measured with the catastrophizing subscale of the Coping Strategies Questionnaire; and HRQOL was measured using the IBS-Quality of Life Measure. Participants perceived their IBS to be a chronic, cyclical condition with negative consequences, moderate symptomatology, and strong negative emotional impact. Their quality of life was poor and catastrophic thinking was noted to be used. Therefore, integrating illness beliefs and coping style into the management of IBS may improve well-being and minimize suffering. [Journal of Psychosocial Nursing and Mental Health Services, 54(9), 44-53.].

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Section: Discussionsupporting

confidence: 92%

Effect of Illness Representations and Catastrophizing on Quality of Life in Adults With Irritable Bowel Syndrome

Sherwin¹,

Leary²,

Henderson³

2016

J Psychosoc Nurs Ment Health Serv

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“…Sleep disturbances are common in IBS patients and may well contribute to reductions in QOL, work productivity, and activity impairment. 12,13 In a preliminary assessment utilizing selected questions from the validated Sleep-50 Questionnaire, we found that the low-FODMAP diet improved overall sleep quality and fatigue at 4 weeks when compared with baseline. However, between group differences were not significantly different.…”

Section: Discussionmentioning

confidence: 91%

“…11 In addition, sleep disorders, which, similar to IBS, are known to exert negative effects on QOL, are reported more commonly in IBS patients than in otherwise healthy persons. 12,13 The reasons underlying the increased prevalence of GI and non-GI comorbidities in IBS patients remain poorly defined but central and peripheral gut-related mechanisms have been postulated. [14][15][16] Up to two-thirds of IBS patients associate symptom onset or exacerbation with eating a meal.…”

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confidence: 99%

A Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and Diarrhea

Eswaran

Chey

Jackson

et al. 2017

Clinical Gastroenterology and Hepatology

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BACKGROUND & AIMS: We investigated the effects of a diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) vs traditional dietary recommendations on health-related quality of life (QOL), anxiety and depression, work productivity, and sleep quality in patients with irritable bowel syndrome and diarrhea (IBS-D). METHODS: We conducted a prospective, single-center, single-blind trial of 92 adult patients with IBS-D (65 women; median age, 42.6 years) randomly assigned to groups placed on a diet low in FODMAPs or a modified diet recommended by the National Institute for Health and Care Excellence (mNICE) for 4 weeks. IBS-associated QOL (IBS-QOL), psychosocial distress (based on the Hospital Anxiety and Depression Scale), work productivity (based on the Work Productivity and Activity Impairment), and sleep quality were assessed before and after diet periods. RESULTS: Eighty-four patients completed the study (45 in the low-FODMAP group and 39 in the mNICE group). At 4 weeks, patients on the diet low in FODMAPs had a larger mean increase in IBS-QOL score than did patients on the mNICE diet (15.0 vs 5.0; 95% CI,-17.4 to-4.3). A significantly higher proportion of patients in the low-FODMAP diet group had a meaningful clinical response, based on IBS-QOL score, than in the mNICE group (52% vs 21%; 95% CI,-0.52 to-0.08). Anxiety scores decreased in the low-FODMAP diet group compared with the mNICE group (95% CI, 0.46-2.80). Activity impairment was significantly reduced with the low-FODMAP diet (-22.89) compared with the mNICE diet (-9.44; 95% CI, 2.72-24.20).

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“…An age cutoff of 50 years was used to limit variability in sleep quality linked with aging 10 . Exclusion criteria for both CD and control subjects included factors that could impact sleep quality which were: functional GI disorders 11 , sleep apnea, BMI > 35, major medical illness (cardiopulmonary disorders, cirrhosis, or significant chronic renal disease or active malignancy), night-shift workers, smokers and heavy drinkers, and patients taking sedating medications (analgesics, muscle relaxants, antineoplastic agents, phenytoin, amphetamines, prescription weight-loss drugs, or benzodiazepines, thyroid medication, and anticholinergic/antihistamine medications) 12 .…”

mentioning

confidence: 99%

Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures

Iskandar

Linan

Patel

et al. 2020

Sci Rep

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Sleep disturbance and fatigue are commonly reported among patients with Crohn's disease (CD). In this prospective study, we aimed to define sleep quality in CD patients at various disease activity states and compare to healthy controls using objective and subjective measures. A prospective observational cohort study of CD patients seen at a tertiary academic inflammatory bowel diseases (IBD) clinic was compared to healthy volunteers. CD activity was assessed using the Harvey-Bradshaw Index (HBI). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) and objectively over 1-week using actigraphy (motion-based) and morning urinary melatonin metabolite. 121 subjects (CD patients N = 61; controls N = 60) completed the study. 34 had active CD (HBI > 4). Sleep disturbance was more frequently reported by CD subjects than controls (PSQI: 57% vs. 35%, p = 0.02) and in patients with active CD versus in remission state (PSQI 75.8% vs. 33.3%, p < 0.01; ESS: 45.5% vs. 19%, p = 0.03). Sleep parameters as measured by actigraphy and urine melatonin metabolite did not vary by group. Crohn's patients report significantly more disturbed sleep than controls. However, poor sleep was not confirmed by objective measures of sleep quality. Excessive daytime sleepiness in CD patients may be driven by factors beyond objectively measured poor sleep. Crohn's disease (CD) is one of the two major types of chronic inflammatory bowel disease (IBD) that together affect nearly 5 million individuals worldwide 1. Fatigue is a common symptom associated with CD, particularly in patients with active disease. While the cause of fatigue can be multifactorial, sleep quality is considered a likely contributing factor 2. Several studies link inflammatory bowel disease, and CD in particular, with sleep disturbance and daytime sleepiness as well as fatigue 2-5. The literature suggests a bidirectional dynamic to the cause-effect relationship of these disorders. Questionnaire-based studies have found that patients with active CD are more likely to have sleep disturbance than those in remission 2,5,6. Alternatively, other questionnaire based studies indicate that sleep disturbance itself may place CD patients at increased risk of disease flares 7,8. Animal studies confirm the latter by demonstrating that circadian disruption worsens colitis severity in experimental models 9. This existing literature highlights the importance of this health issue; however most studies to date are limited by small patient cohorts or lack of objective sleep quality assessments or healthy controls for comparison. To assess the relationship between CD and sleep we conducted a prospective cohort study examining both subjective and objective measures of sleep disturbance. Using these tools, we sought to determine whether CD diagnosis alone was associated with sleep disturbance and whether disease activity influenced sleep quality. Additionally, we examined a urinary metabolite of melatonin to determine if melatonin deficiency may e...

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Effects of disturbed sleep on gastrointestinal and somatic pain symptoms in irritable bowel syndrome

Cited by 70 publications

References 58 publications

Effect of Illness Representations and Catastrophizing on Quality of Life in Adults With Irritable Bowel Syndrome

Effect of Illness Representations and Catastrophizing on Quality of Life in Adults With Irritable Bowel Syndrome

A Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and Diarrhea

Self-reported sleep disturbance in Crohn’s disease is not confirmed by objective sleep measures

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