A Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and Diarrhea

Eswaran, Shanti; Chey, William D.; Jackson, Kenya; Pillai, Sivaram; Chey, Samuel W.; Han-Markey, Theresa

doi:10.1016/j.cgh.2017.06.044

Cited by 80 publications

(79 citation statements)

References 43 publications

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“…A significant proportion (37.5%) of the participants demonstrated a clinically significant improvement in QoL as measured by the validated IBS‐QOL instrument (>14 points) at 26 weeks after initiation of the diet . The magnitude of improvement of QoL is also similar to that seen in other dietary intervention studies of low‐FODMAP diet in IBS patients …”

Section: Discussionsupporting

confidence: 76%

“…Recently, Eswaran et al described the results of a randomized controlled trial of low‐FODMAP diet compared with standard dietary advice, including a substudy describing QoL, anxiety, depression, and sleep as outcomes after 4 weeks of follow‐up. Significant improvements were seen in each of these outcomes . Similarly, Staudacher et al demonstrated improvements in some aspects but not overall QoL for low‐FODMAP diet compared with a sham diet but also only after 4 weeks of follow‐up .…”

Section: Introductionmentioning

confidence: 89%

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Low‐FODMAP Diet Is Associated With Improved Quality of Life in IBS Patients—A Prospective Observational Study

et al. 2019

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Background:The low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet is effectively manages irritable bowel syndrome (IBS) symptoms. Long-term low-FODMAP studies rarely report quality of life (QoL). We aimed to determine the effect of low-FODMAP diet on long-term QoL, gastrointestinal (GI) and non-GI symptoms in IBS patients. Methods: A prospective observational study of IBS patients referred for low-FODMAP dietary advice was performed. The primary outcome of QoL and secondary outcomes of GI symptoms, anxiety/depression, fatigue, sleep quality, and happiness were obtained at baseline, 6 weeks (T6), and 6 months (T26). Results: 111 patients were recruited. 91.0%, 71.6%, and 50.5% of participants completed baseline, T6, and T26 assessments, respectively. There were significant improvements in QoL from baseline at T6 and T26 (both P < 0.001). Significant reductions were seen in GI symptoms at T6 and T26 (both P < 0.001), fatigue at T6 and T26 (both P < 0.003), and anxiety at T6 and T26 (both P < 0.007), compared with baseline. A significant reduction was seen for depression (P < 0.010) from baseline at T26, and a significant increase was seen for both happiness and vitality (both P < 0.04) from baseline at T26. There was a significant correlation between GI symptom response and change in QoL, anxiety, depression, and fatigue (all P < 0.034). Conclusion: Low-FODMAP diet was associated with improved long-term QoL and GI symptoms, reduced fatigue and anxiety/depression, and increased happiness and vitality. These data support a wider range of benefits for IBS patients consuming a low-FODMAP diet. (Nutr Clin Pract. 2019;34:623-630)

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 89%

Low‐FODMAP Diet Is Associated With Improved Quality of Life in IBS Patients—A Prospective Observational Study

et al. 2019

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“…No differences were previously observed in the efficacy of the approaches regarding quality of life, with both leading to a significant improvement in the overall score [17][18][19]24,25]. However, our study showed higher effectiveness for LFD in improving individuals QOL according to the IBS-QOL scores.…”

Section: Discussioncontrasting

confidence: 68%

Effectiveness of Two Dietary Approaches on the Quality of Life and Gastrointestinal Symptoms of Individuals with Irritable Bowel Syndrome

Guerreiro

Santos

Carolino

et al. 2020

JCM

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To evaluate the effectiveness of a low FODMAP (fermentable oligosaccharides, monosaccharaides, disaccharides and polyols) diet in the relief of symptoms and an improvement of the quality of life in individuals with irritable bowel syndrome in comparison to a standard diet according to the British Dietetic Association’s guidelines. A non-randomized clinical trial of adult patients with IBS was compared two diet interventions. An assessment of symptoms, quality of life, and nutritional status was performed before and after the four-week mark of intervention. Individuals from the Low FODMAP Diet (LFD) group were evaluated on a third moment, after the controlled reintroduction of FODMAPs. A total of 70 individuals were divided in two groups: Low FODMAP Diet (LFD; n = 47) and Standard Diet (SD; n = 23). 57 individuals completed the four-week intervention (LFD; n = 39; SD; n = 18). At the completion of four weeks, the symptoms improved in both groups (LFD: p < 0.01; DC: p < 0.05) but LFD led to a higher relief (p < 0.05), primarily with respect to abdominal pain and diarrhoea. Quality of life improved significantly in both groups, with no significant differences between SD vs LFD (p > 0.05). In the LFD group, the relief of symptoms observed at the four-week mark remained constant after reintroduction of FODMAPs. Both interventions seem to be effective for the relief of symptoms and quality of life, however LFD had higher effectiveness in the former. The results with LFD suggest it can be a preferred approach in individuals with diarrhoeal profile.

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“…15,16 A significant benefit of low-FODMAP diet on health-related QOL, as well as on improving GI symptoms, has also been demonstrated in a randomized controlled study. 33 Meanwhile, a recent placebo-controlled dietary advice trial, which made excellent efforts to maintain blinding, has shown that the difference in symptom relief between a low-FODMAP diet and a "sham diet" was borderline significant in the intention-to-treat analysis. 34 Although there is increasing evidence supporting the use of low-FODMAP diets as an IBS treatment, clinical data supporting the application of this strategy to Korean IBS patients are lacking.…”

Section: Discussionmentioning

confidence: 99%

Self-reported Food Intolerance in Korean Patients With Irritable Bowel Syndrome

Lee

Kim

Kang

et al. 2019

J Neurogastroenterol Motil

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Background/Aims Various foods trigger and/or worsen the symptoms of irritable bowel syndrome (IBS). However, Korean food-related gastrointestinal (GI) symptoms in IBS patients have not yet been investigated. This study aims to evaluate the prevalence of self-reported food intolerance in Korean IBS patients and determine the Korean food items and food groups perceived by patients to worsen their GI symptoms. Methods We recruited 393 study subjects, comprising 101 IBS patients, 167 symptomatic non-IBS subjects, and 125 control subjects. All participants completed a questionnaire to identify the most problematic foods and assess the occurrence of GI symptoms caused by 119 Korean food items. They also completed the validated Rome III questionnaire for IBS. Results The prevalence of self-reported food intolerance in Korean IBS patients was 79.2%, which was significantly higher than that in control subjects (44.8%, P < 0.001). The most problematic foods reported by IBS patients who experienced food intolerance were high-fat foods (25.0%), gluten foods (23.8%), spicy foods (15.0%), and dairy products (15.0%). A total of 63.4% of IBS patients reported GI symptoms related to the consumption of foods high in fermentable oligo-, di-, mono-saccharides, and polyols (FODMAP), while 48.5% of IBS patients reported symptoms associated with high-fat foods. Gas problems and loose stools were the most frequently reported symptoms. Conclusions A large proportion of Korean IBS patients complained of intolerance to certain food items, with high-fat and high-FODMAP foods being the main triggers. This study provides a basis for planning food intervention studies for Korean IBS patients.

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A Diet Low in Fermentable Oligo-, Di-, and Monosaccharides and Polyols Improves Quality of Life and Reduces Activity Impairment in Patients With Irritable Bowel Syndrome and Diarrhea

Cited by 80 publications

References 43 publications

Low‐FODMAP Diet Is Associated With Improved Quality of Life in IBS Patients—A Prospective Observational Study

Low‐FODMAP Diet Is Associated With Improved Quality of Life in IBS Patients—A Prospective Observational Study

Effectiveness of Two Dietary Approaches on the Quality of Life and Gastrointestinal Symptoms of Individuals with Irritable Bowel Syndrome

Self-reported Food Intolerance in Korean Patients With Irritable Bowel Syndrome

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